Navegando por Palavras-chave "Ocular surface inflammation"

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    Conjunctival impression cytology evaluation of patients with dry eye disease using scleral contact lenses
    (Elsevier Science Bv, 2017) Weber, Sarah La Porta [UNIFESP]; Hazarbassanov, Rossen Mihaylov [UNIFESP]; Nasare, Alex [UNIFESP]; Pereira Gomes, Jose Alvaro [UNIFESP]; Hofling-Lima, Ana Luisa [UNIFESP]
    Purpose: To evaluate conjunctival impression cytology and HLADR expression changes after wearing scleral contact lenses (ScCLs) for moderate to severe dry eye disease (DED). Design: Prospective interventional case series. Methods: Forty-one eyes from 25 patients with moderate to severe DED were evaluated for Esclera ScCL treatment. Best-corrected visual acuity (BCVA) and slit-lamp findings were assessed. Impression cytology specimens were obtained from DED patients at the baseline and after wearing ScCLs for 12 months. The impression cytology specimens were analyzed using morphological results score, and HLADR positive cells were detected and quantified. The values were compared to assess the IC changes after wearing ScCLs. Results: Forty-one eyes from 25 patients were fitted with ScCLs to manage DED. The underlying diseases were Stevens-Johnson syndrome (22 eyes), Sjogren's syndrome (11 eyes), graft-versus-host disease (2 eyes), dry eye after keratomileusis (2 eyes) and undifferentiated ocular surface disease (4 eyes). The HEPAS impression cytology score did not differ significantly before and after wearing ScCLs for 12 months in DED patients (p > 0.05). The percentage of eyes expressing the HLA-DR antigen in the temporal conjunctiva after wearing ScCL for 12 months significantly increased in patients with Sjogren's syndrome (11.11% to 66.66%