Navegando por Palavras-chave "PAMPs"

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    Sistema imunitário - parte II: fundamentos da resposta imunológica mediada por linfócitos T e B
    (Sociedade Brasileira de Reumatologia, 2010-10-01) Mesquita Júnior, Danilo [UNIFESP]; Araújo, Júlio Antônio Pereira; Catelan, Tânia Tieko Takao [UNIFESP]; Souza, Alexandre Wagner Silva de [UNIFESP]; Cruvinel, Wilson de Melo [UNIFESP]; Andrade, Luiz Eduardo Coelho [UNIFESP]; Silva, Neusa Pereira da [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The immune system consists of an intricate network of organs, cells, and molecules responsible for maintaining the body's homeostasis and responding to aggression in general. Innate immunity operates in conjunction with adaptive immunity and is characterized by rapid response to aggression, regardless of previous stimulus, being the organism first line of defense. Its mechanisms include physical, chemical and biological barriers, cellular components, as well as soluble molecules. The organism first line of defense against tissue damage involves several steps closely integrated and constituted by different components of this system. The aim of this review is to restore the foundations of this response, which has high complexity and consists of several components that converge to articulate the development of adaptive immune response. We selected some of the following steps to review: perception and molecular recognition of aggressive agents; activation of intracellular pathways, which result in vascular and tissue changes; production of a myriad of mediators with local and systemic effects on cell activation and proliferation, synthesis of new products involved in the chemoattraction and migration of cells specialized in destruction and removal of offending agent; and finally, tissue recovery with restoration of functional tissue or organ.
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    Sistema imunitário: Parte I. Fundamentos da imunidade inata com ênfase nos mecanismos moleculares e celulares da resposta inflamatória
    (Sociedade Brasileira de Reumatologia, 2010-08-01) Cruvinel, Wilson de Melo [UNIFESP]; Mesquita Júnior, Danilo [UNIFESP]; Araújo, Júlio Antônio Pereira; Catelan, Tânia Tieko Takao [UNIFESP]; Souza, Alexandre Wagner Silva de [UNIFESP]; Silva, Neusa Pereira da [UNIFESP]; Andrade, Luiz Eduardo Coelho [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Pontifícia Universidade Católica de Goiás cursos de Medicina e Biomedicina
    The immune system consists of an intricate network of organs, cells, and molecules responsible for maintaining the body's homeostasis and responding to aggression in general. Innate immunity operates in conjunction with adaptive immunity and is characterized by rapid response to aggression, regardless of previous stimulus, being the organism first line of defense. Its mechanisms include physical, chemical and biological barriers, cellular components, as well as soluble molecules. The organism first line of defense against tissue damage involves several steps closely integrated and constituted by different components of this system. The aim of this review is to restore the foundations of this response, which has high complexity and consists of several components that converge to articulate the development of adaptive immune response. We selected some of the following steps to review: perception and molecular recognition of aggressive agents; activation of intracellular pathways, which result in vascular and tissue changes; production of a myriad of mediators with local and systemic effects on cell activation and proliferation, synthesis of new products involved in the chemoattraction and migration of cells specialized in destruction and removal of offending agent; and finally, tissue recovery with restoration of functional tissue or organ.
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    Acesso aberto (Open Access)
    Sistema imunitário: parte III. O delicado equilíbrio do sistema imunológico entre os pólos de tolerância e autoimunidade
    (Sociedade Brasileira de Reumatologia, 2010-12-01) Souza, Alexandre Wagner Silva de [UNIFESP]; Mesquita Júnior, Danilo [UNIFESP]; Araújo, Júlio Antônio Pereira; Catelan, Tânia Tieko Takao [UNIFESP]; Cruvinel, Wilson de Melo [UNIFESP]; Andrade, Luiz Eduardo Coelho [UNIFESP]; Silva, Neusa Pereira da [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Pontifícia Universidade Católica de Goiás cursos de Medicina e Biomedicina
    The immune system consists of an intricate network of organs, cells, and molecules responsible for maintaining the body's homeostasis and responding to aggression in general. Innate immunity operates in conjunction with adaptive immunity and is characterized by rapid response to aggression, regardless of previous stimulus, being the organism first line of defense. Its mechanisms include physical, chemical and biological barriers, cellular components, as well as soluble molecules. The organism first line of defense against tissue damage involves several steps closely integrated and constituted by different components of this system. The aim of this review is to restore the foundations of this response, which has high complexity and consists of several components that converge to articulate the development of adaptive immune response. We selected some of the following steps to review: perception and molecular recognition of aggressive agents; activation of intracellular pathways, which result in vascular and tissue changes; production of a myriad of mediators with local and systemic effects on cell activation and proliferation, synthesis of new products involved in the chemoattraction and migration of cells specialized in destruction and removal of offending agent; and finally, tissue recovery with restoration of functional tissue or organ