Navegando por Palavras-chave "Papilloma"
Agora exibindo 1 - 6 de 6
Resultados por página
Opções de Ordenação
- ItemAcesso aberto (Open Access)Aplicação local de cidofovir como tratamento adjuvante na papilomatose laríngea recorrente em crianças(Associação Médica Brasileira, 2009-01-01) Pontes, Paulo [UNIFESP]; Weckx, Luc Louis Maurice [UNIFESP]; Pignatari, Shirley Shizue Nagata [UNIFESP]; Fujita, Reginaldo Raimundo [UNIFESP]; Avelino, Melissa Ameloti Gomes [UNIFESP]; Sato, Juliana [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: Evaluate the efficacy of local application of cidofovir in association with surgical treatment of recurrent laryngeal papillomatosis in children. Study design: Prospective. METHODS: Fourteen patients, with an average age of 4.7 years and with two or more relapses after surgical treatment, were submitted to resection of the papillomas and injection of 22.5 mg of cidofovir (7.5 mg/ml) in the tissue where the lesions had been removed. After 2 to 3 week intervals, the same dose of cidofovir was repeated two or three times. In the case of relapse, a new cycle of surgery followed by local applications of cidofovir was repeated. Five children presented HPV-6 and five HPV-11, while in four, the type was not determined. RESULTS: Before beginning of the study, patients were submitted, on the average, to 2 operations a year for control of relapses. After treatment with cidofovir, the annual rate for surgery dropped to 1.1 (p = 0.013). The average interval between relapses before beginning of the study was 1.4 months; at the end of the study, the interval reached 4.4 months (p = 0.014). Patients with HPV-6 did not show a significant change in the intervals between relapses after treatment with cidofovir, while 60% of the children with HPV-11 were disease free at the study end. CONCLUSION: Cidofovir was found to be an effective adjuvant in the treatment of recurrent laryngeal papillomatosis in children, when used in the form of local applications in association with surgical resection of the lesions. HPV-11 may be more susceptible to the beneficial effects of cidofovir.
- ItemSomente MetadadadosAspectos histológicos e de biologia molecular da papilomatose do vestíbulo vulvar e sua relação com o papilomavirus humano(Universidade Federal de São Paulo (UNIFESP), 1994) Deus, José Miguel de [UNIFESP]; Focchi, José [UNIFESP]
- ItemSomente MetadadadosEffectiveness of the human papillomavirus (types 6, 11, 16, and 18) vaccine in the treatment of children with recurrent respiratory papillomatosis(Elsevier Ireland Ltd, 2016) Hermann, Juliana Sato [UNIFESP]; Weckx, Lily Yin [UNIFESP]; Nurmberger, Jussimara Monteiro; Santos Junior, Gildo Francisco dos; Pignatari, Antonio Carlos Campos [UNIFESP]; Pignatari, Shirley Shizue Nagata [UNIFESP]Objective: To evaluate whether the quadrivalent human papillomavirus (HPV) (types 6, 11, 16, and 18) vaccine influences the clinical course of juvenile-onset recurrent respiratory papillomatosis (RRP) when administered to a group of patients with this condition. Methods: Uncontrolled intervention study of patients with juvenile-onset RRP examined at the Pediatric Otorhinolaryngology Clinic, Federal University of Sao Paulo, where nine patients between the ages of nine and 17 received three doses of the prophylactic quadrivalent HPV vaccine (Gardasil) and were followed for one year. Disease staging, intervals between relapses, intervals between surgeries, and the number of surgeries during the year prior to vaccination and during the first year after vaccination were compared. Results: Eight patients were infected with HPV-6 and one with HPV-11. There were no statistically significant differences in the clinical scores (p = 0.083), anatomical scores (p = 0.257), intervals between relapses (p = 0.062), intervals between surgeries (p = 0.357), or the numbers of surgeries (p = 0.180) when the years before and after vaccination were compared. All patients had relapses following vaccination. Conclusion: Patients with juvenile-onset RRP experienced a similar clinical course in the year after versus the year before vaccination with Gardasil. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
- ItemSomente MetadadadosGrade II atypical choroid plexus papilloma with normal karyotype(Springer, 2009-12-01) Brassesco, Maria Sol; Valera, Elvis Terci; Becker, Aline Paixao; Oliveira, Ricardo Santos; Scrideli, Carlos Alberto; Machado, Helio Rubens; Tone, Luiz Gonzaga; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Cytogenetic studies of atypical choroid plexus papillomas (CPP) have been poorly described. in the present report, the cytogenetic investigation of an atypical CPP occurring in an infant is detailed.CPP chromosome preparations were analyzed by giemsa-trypsin-banding (GTG-banding) and comparative genome hybridization (CGH).Conventional karyotype analysis of tumor culture showed a normal chromosome complement. the results were confirmed by CGH, showing normal hybridization patterns for the sample.To date, the few atypical CPPs described in the literature have shown disparate cytogenetic information. This is the first report of a normal chromosome complement in atypical CPP. the heterogenic genetic features observed in these small series may reflect the diverse genetic background of choroid plexus tumors in children.
- ItemAcesso aberto (Open Access)Laryngeal sequelae of recurrent respiratory papillomatosis surgery in children(Associação Médica Brasileira, 2012-04-01) Hermann, Juliana Sato [UNIFESP]; Pontes, Paulo [UNIFESP]; Weckx, Luc Louis Maurice [UNIFESP]; Fujita, Reginaldo Raimundo [UNIFESP]; Avelino, Melissa Ameloti Gomes [UNIFESP]; Pignatari, Shirley Shizue Nagata [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)OBJECTIVE: To evaluate laryngeal sequelae from surgical treatment of recurrent respiratory papillomatosis in children, as well as associated risk factors. METHODS: Case-control study. Medical record data analysis of 50 children with recurrent respiratory papillomatosis, divided into two groups: with and without laryngeal sequelae. The group of patients with laryngeal sequelae was compared to those without sequelae in regard to the onset of disease, age at first surgery, number and frequency of surgeries, disease stage, and type of surgery (CO2 laser, cold forceps). RESULTS: 23 patients (46%) sustained laryngeal sequelae. The most frequent sequela was anterior commissure synechia (17 patients [34%]), followed by glottic stenosis (six patients [12%]). There was no statistically significant difference between groups with and without laryngeal sequelae regarding the disease onset (p = 0.93), age at first surgery (p = 0.68), number of surgeries (p = 0.22), annual frequency of surgery (p = 0.93), presence of papilloma in anterior (p = 0.430) or posterior commissure (p = 0.39), and type of surgery (p = 0.27). The Derkay anatomical score (a staging system that assesses the extent of the disease in the aerodigestive tract) was significantly higher in the laryngeal sequelae group (p = 0.04). CONCLUSION: Laryngeal sequelae are a frequent complication of recurrent respiratory papillomatosis surgical treatment in children, particularly anterior commissure synechiae and glottic stenosis. Advanced stages are associated with increased risk of laryngeal sequelae after surgery.
- ItemAcesso aberto (Open Access)Papilomatose laringotraqueobrônquica: aspectos em tomografia computadorizada de tórax(Sociedade Brasileira de Pneumologia e Tisiologia, 2008-12-01) Marchiori, Edson; Araujo Neto, Cesar de; Meirelles, Gustavo de Souza Portes [UNIFESP]; Irion, Klaus Loureiro; Zanetti, Gláucia; Missrie, Israel [UNIFESP]; Sato, Juliana [UNIFESP]; Universidade Federal Fluminense Departamento de Radiologia; Universidade Federal da Bahia; Universidade Federal de São Paulo (UNIFESP); Broadgreen University Hospitals Royal Liverpool; Faculdade de Medicina de PetrópolisOBJECTIVE: To present the findings of computed tomography (CT) scans of the chest in patients with laryngotracheobronchial papillomatosis. METHODS: We retrospectively analyzed CT scans of eight patients, five males and three females, ranging from 5 to 18 years of age with a mean age of 10.5 years. Images were independently reviewed by two radiologists. In discrepant cases, a consensus was reached. RESULTS: The most common CT findings were intratracheal polypoid lesions and pulmonary nodules, many of which were cavitated. CONCLUSIONS: In patients with laryngotracheobronchial papillomatosis, the most common tomographic finding was the combination of intratracheal polypoid lesions and multiple pulmonary nodules, many of which were cavitated.