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- ItemSomente MetadadadosAnalise do polimorfismo do gene dos receptores de progesterona(progins), da raca e da paridade como fatores relacionados ao desenvolvimento de leiomioma do utero(Universidade Federal de São Paulo (UNIFESP), 2005) Gomes, Mariano Tamura Vieira [UNIFESP]
- ItemAcesso aberto (Open Access)Assessment of pelvic floor by three-dimensional-ultrasound in primiparous women according to delivery mode: initial experience from a single reference service in Brazil(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2013-03-01) Araujo Júnior, Edward [UNIFESP]; Freitas, Rogério Caixeta Moraes De [UNIFESP]; Di Bella, Zsuzsanna Ilona Katalin De Jármy [UNIFESP]; Alexandre, Sandra Maria [UNIFESP]; Nakamura, Mary Uchiyama [UNIFESP]; Nardozza, Luciano Marcondes Machado [UNIFESP]; Moron, Antonio Fernandes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: To evaluate changes to the pelvic floor of primiparous women with different delivery modes, using three-dimensional ultrasound. METHODS: A prospective cross-sectional study on 35 primiparae divided into groups according to the delivery mode: elective cesarean delivery (n=10), vaginal delivery (n=16), and forceps delivery (n=9). Three-dimensional ultrasound on the pelvic floor was performed on the second postpartum day with the patient in a resting position. A convex volumetric transducer (RAB4-8L) was used, in contact with the large labia, with the patient in the gynecological position. Biometric measurements of the urogenital hiatus were taken in the axial plane on images in the rendering mode, in order to assess the area, anteroposterior and transverse diameters, average thickness, and avulsion of the levator ani muscle. Differences between groups were evaluated by determining the mean differences and their respective 95% confidence intervals. The proportions of levator ani muscle avulsion were compared between elective cesarean section and vaginal birth using Fisher's exact test. RESULTS: The mean areas of the urogenital hiatus in the cases of vaginal and forceps deliveries were 17.0 and 20.1 cm², respectively, versus 12.4 cm² in the Control Group (elective cesarean). Avulsion of the levator ani muscle was observed in women who underwent vaginal delivery (3/25), however there was no statistically significant difference between cesarean section and vaginal delivery groups (p=0.5). CONCLUSION: Transperineal three-dimensional ultrasound was useful for assessing the pelvic floor of primiparous women, by allowing pelvic morphological changes to be differentiated according to the delivery mode.
- ItemSomente MetadadadosDesfecho obstetrico em adolescentes primiparas(Universidade Federal de São Paulo (UNIFESP), 2007) Rocha, Ricardo Cristiano Leal da [UNIFESP]
- ItemSomente MetadadadosEstudo comparativo dos conhecimentos sobre aleitamento materno entre primigestas, adolescentes e adultas, atendidas em serviço de assistência ao pré-natal(Universidade Federal de São Paulo (UNIFESP), 2000) Bandeira, Claudete Regina Sanchez [UNIFESP]; Fisberg, Mauro [UNIFESP]
- ItemSomente MetadadadosInfluencia da gestação e do parto na localização da zona de transformação atípica colposcópica(Universidade Federal de São Paulo (UNIFESP), 1983) Focchi, José [UNIFESP]
- ItemSomente MetadadadosInfluência dos intervalos intergestacionais e da paridade sobre a mortalidade infantil(Universidade Federal de São Paulo (UNIFESP), 1986) Araujo, Fabio Fernando de [UNIFESP]; Lima, Geraldo Rodrigues de [UNIFESP]
- ItemAcesso aberto (Open Access)Relação entre polimorfismo do gene do receptor de progesterona, raça, paridade e ocorrência de leiomioma uterino(Federação Brasileira das Sociedades de Ginecologia e Obstetrícia, 2006-05-01) Gomes, Mariano Tamura Vieira [UNIFESP]; Castro, Rodrigo de Aquino [UNIFESP]; Villanova, Fabiola Elizabeth [UNIFESP]; Silva, Ismael Dale Cotrim Guerreiro da [UNIFESP]; Baracat, Edmund Chada [UNIFESP]; Lima, Geraldo Rodrigues de [UNIFESP]; Girão, Manoel João Batista Castello [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)PURPOSE: to analyze race, parity and presence of the progesterone receptor polymorphism, named PROGINS, as factors related to uterine leiomyoma occurrence in Brazilian women. METHODS: we carried out a case-control study, composed of 122 patients with the diagnosis of uterine fibroid and 125 women without the disease. After recording the clinical data, we collected biological material for DNA extraction, polymerase chain reaction and agarose gel electrophoresis in order to identify the presence of PROGINS polymorphism. Statistical analysis was performed using the non-parametric Mann-Whitney test or the chi2 test, depending on the studied variable. The risk for the occurrence of the disease was calculated by the logistic regression model, providing the odds ratio (OR). The adopted significance level was 5% (p<0.05) and the confidence interval was 95% (95% CI). RESULTS: we observed a higher prevalence of non-whitewomen - mulatto and black - (50 vs 22.4%) and nulliparas (23.8 vs 11.2%) in the cases, while the progesterone receptor genotype was more often PROGINS positive - heterozygous or mutant homozygous - among the controls (21.6 vs 10.7%). The OR indicated an elevated risk for leiomyoma related to the non-whiterace (OR=3.46; 95% CI: 2.0-6.0) and the nulliparity (OR=3.30; 95% CI: 1.9-5.6), with reduction in the presence of PROGINS-positive genotypes (OR=0.43; 95% CI: 0.2-0.9). CONCLUSIONS: the non-whiterace and nulliparity were considered risk factors for the occurrence of uterine fibroid in the studied population, while PROGINS polymorphism showed to be a protective factor.