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    Sakuranetin reverses vascular peribronchial and lung parenchyma remodeling in a murine model of chronic allergic pulmonary inflammation
    (Cadernos Saude Publica, 2016) Pedroso Sakoda, Camila Pivari [UNIFESP]; de Toledo, Alessandra Choqueta; Perini, Adenir; Pinheiro, Nathalia Montouro; Hiyane, Meire Ioshie; Grecco, Simone dos Santos [UNIFESP]; Lopes Calvo Tiberio, Iolanda de Fatima; Saraiva Camara, Niels Olsen; Martins, Milton de Arruda; Ghilardi Lago, Joao Henrique [UNIFESP]; Righetti, Renato Fraga; Prado, Carla Maximo [UNIFESP]
    Background and purpose: Asthma is a disease of high prevalence and morbidity that generates high costs in hospitalization and treatment. Although the airway is involved in the physiopathology of asthma, there is also evidence of the importance of vascular and lung parenchyma inflammation and remodeling, which can contribute to the functional pulmonary alterations observed in asthmatic patients. Our aim was to evaluate treatment using sakuranetin, a flavone isolated from the twigs of Baccharis retusa (Asteraceae), on vascular and lung parenchyma alterations in an experimental murine model of asthma. Methods: Male BALB/c mice were subjected to a sensitization protocol with ovalbumin for 30 days and were treated with or without sakuranetin (20 mg/kg/mice) or dexamethasone (5 mg/kg/mice)