Navegando por Palavras-chave "Petiveria alliacea"

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    The effectiveness of tipi in the treatment of hip and knee osteoarthritis: a preliminary report
    (Instituto Oswaldo Cruz, Ministério da Saúde, 1991-01-01) Ferraz, Marcos Bosi [UNIFESP]; Pereira, Ronaldo Borges [UNIFESP]; Andrade, Luiz Eduardo Coelho [UNIFESP]; Atra, Edgard [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Osteoarthritis (OA) is a common painful inflammatory condition occurring mainly in the later half of life. Hipe and knee are the joints mostly affected. Petiveria alliacea (tipi) popularly known as an anti-rheumatic medicine, has been used by OA patients to relief pain. This one-week cross-over double-blind trial has preliminary evaluated the analgesic effect of tipi tea in 14 patients with hip and knee OA. Imperata exaltata (sape) was used as the Placebo tea. The pain assessments that were made at baseline and before the start of the second treatment period by treatment groups were comparable. While taking tipi or placebo tea patients experienced a statistically significant improvement in pain on motion and pain at night. The comparison between the improvements reported while on tipi and placebo tea, however, did not disclose any statistically significant difference. At the conclusion of the study 7 patients preferred tipi tea and 6 preferred placebo tea (NS). Two patients reported insomnia, one durign placebo treatment and the other during tipi treatment. In this preliminary report both teas succeeded in the aim of relieving pain.
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    Estudo da avaliação antiparasitária de extratos e constituintes químicos das folhas de Petiveria alliacea L. (phytolaccaceae)
    (Universidade Federal de São Paulo, 2015-09-25) Sessa, Deborah Pelosi [UNIFESP]; Lago, João Henrique Ghilardi [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    This work reports the phytochemical study of leaves from Petiveria alliacea L. (Phytolaccaceae), aiming the characterization of antiparasitic compound. The hexanic and methanol extracts from the leaves were subjected to successive chromatographic procedures to afford two triterpenes: oleanolic (I) and ursolic (II) acids, three flavonoids: sakuranetin (IV); quercetin (V) and patuletin (VI) as well as one glycosylated: kaempferol-3-O-?-L-rhamnopyranosyl-(1?4)-?-D-glucopyranoside (III), being the first occurrence of III, IV and VI in P. alliacea. The structures of substances were characterized through analysis of 1H and 13C NMR and MS spectra followed by the comparison of reported data. Extracts and purified compounds were evaluated for their antiparasitic potential, against L (L.) infantum (amastigote and promastigote), indicating that compounds I ? V demonstrated activity for amastigotes. Compounds II and III showed IC50 values determined as 13.4 and 17.3 ?g/mL, respectively, and lower than to the positive control pentamidine (22.1 ?g/mL). Additionally compounds I, II, V + VI and V showed reduced toxicity against mammalian cells LLC-MK2 lineage. Therefore this study are intended to provide new prototypes for development of new drug for the treatment of parasite diseases.