Navegando por Palavras-chave "Porphyrins"

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    Avaliação da função macular por eletrorretinografia focal e por angiofluoresceinografia em pacientes com degeneração macular relacionada à idade neovascular submetidos à terapia fotodinâmica com verteporfina
    (Conselho Brasileiro de Oftalmologia, 2009-02-01) Oshima, Akiyoshi [UNIFESP]; Berezovsky, Adriana [UNIFESP]; Salomão, Solange Rios [UNIFESP]; Sacai, Paula Yuri [UNIFESP]; Costa, Rogerio Alves [UNIFESP]; Bordon, Arnaldo Furman; Farah, Michel Eid [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Hospital Oftalmológico de Sorocaba Setor de Retina e Vítreo
    PURPOSE: To evaluate macular function by focal electroretinography and fluorescein angiography (FA) in patients with neovascular age-related macular degeneration submitted to verteporfin photodynamic therapy (VPT). METHODS: Prospective study involving 22 patients with age-related macular degeneration and predominantly classic subfoveal neovascular membrane, in non consecutive series, treated with VPT and followed for 12 months. They had their best corrected visual acuity measured by ETDRS chart, changes of lesion measured by fluorescein angiography and cone function assessed by focal electroretinography at baseline and each 3month follow-up. RESULTS: All 22 patients completed the scheduled follow-up. After a mean of 3.5 sessions of treatment per patient, the mean visual acuity variation was not significant at the end of study. Eleven patients showed variation >1 line. 86% of patients achieved stabilization of lesion leakage at the end of the study. Focal electroretinography showed a mean of 194.88 nV in amplitude and 29.19 ms in latency and did not present a significant variation during treatment. CONCLUSIONS: There were no significant differences in focal electroretinography amplitudes and latencies after a 9-month period. Visual acuity did not show important variations during the 12 months. The decrease of lesion size showed a significant difference at 12 months with negative correlation between the amplitude of focal electroretinography and best corrected visual acuity.
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    Degeneração macular relacionada à idade: modalidades terapêuticas
    (Conselho Brasileiro de Oftalmologia, 2001-11-01) Farah, Michel Eid [UNIFESP]; Oshima, Akiyoshi [UNIFESP]; Costa, Rogerio Alves [UNIFESP]; Sallum, Juliana Ferraz [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    To describe the clinical and surgical therapeutic modalities in age-related macular degeneration (ARMD).
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    Specific effects of reactive thiol drugs on mitochondrial bioenergetics
    (Springer, 2011-02-01) Nantes, Iseli L.; Rodrigues, Tiago; Caires, Antonio C. F.; Cunha, Rodrigo L. O. R.; Pessoto, Felipe S. [UNIFESP]; Yokomizo, Cesar H.; Araujo-Chaves, Juliana C.; Faria, Priscila A.; Santana, Debora P.; Santos, Carolina G. dos; Universidade Federal do ABC (UFABC); Univ Mogi das Cruzes; Universidade Federal de São Paulo (UNIFESP)
    In this minireview, the more recent findings about the effects of peculiar reactive thiol drugs on mitochondria are presented. These include the following compounds: metallo meso-tetrakis porphyrins, palladacycles, telluranes and phenothiazines. Metallo meso-tetrakis porphyrins can exhibit both beneficial and deleterious effects on mitochodria that are modulated by the central metal, cell location, and availability of axial ligands. Therefore, these compounds have the versatility to be used for cell and mitochondria protection and death. the antioxidant activity of manganese porphyrins is related to a glutathione peroxidase-like activity. By attacking exclusively the membrane protein thiol groups without glutathione depletion, palladacycles are able to induce mitochondrial permeability transition (MPT) and cytochrome c release in the absence of oxidative stress. in hepatoma cells, the mitochondrial action of palladacycles was able to induce apoptotic death. As opposed to palladacycles, telluranes and phenothiazines are able to conjugate the capacity to promote the MPT in a dose-dependent manner in association with efficient antioxidant activity toward lipids. These studies demonstrated that the action of drugs on mitochondrial bioenergetics can be modulated by peculiar reactivity with thiol groups. Therefore, they contribute to studies of toxicity as well as the design of new drugs.