Navegando por Palavras-chave "Propofol"
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- ItemAcesso aberto (Open Access)Avaliação farmacodinâmica e análise físico-química de duas formulações de propofol usadas em infusão alvo-controlada(Sociedade Brasileira de Anestesiologia, 2013-02-01) Simoni, Ricardo Francisco; Miziara, Luiz Eduardo De Paula Gomes; Esteves, Luis Otávio; D'castro, João Gilberto Ribeiro; Morales Jr, Carlos Alberto; Sandrin, Carlos Eduardo Esqueapatti; Contente, Thaís Costa; Oliveira-Silva, Diogo [UNIFESP]; Instituto Penido Burnier Sociedade Brasileira de Anestesiologia Centro de Ensino e Treinamento; Centro Médico de Campinas; Hospital Santa Sofia; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)BACKGROUND AND OBJECTIVES: There are several formulations of propofol available to the anesthesiologist for clinical use. The aim of this study was to analyze the physicochemical properties, pharmacodynamic effect, and pharmaceutical and clinical equivalence of the reference drug propofol as well as a similar formulation. METHOD: Sixteen volunteers were enrolled in this randomized, double-blind, and paired study of Diprivan® and Propovan® formulations. Formulations were given as target-controlled infusion with target concentration of 3.0 μg.mL-1 for 15 minutes. Variables studied were the area under the curve (AUC) of the bispectral index (BIS) graph regarding time, minimum BIS reached and time to reach it, and recovery time. The two formulations were sent to analysis of particle size of lipid emulsion, surface potential, and active principle quantification. RESULTS: There was no difference between the formulations when comparing AUC, minimum BIS reached and time to reach it. The similar formulation recovery time was lower compared to the reference formulation (eight and 10 min, respectively, p = 0.014). Mean particle size of lipid emulsion, surface potential, and active ingredient quantification were similar for both formulations. CONCLUSION: There was no clinically significant difference between the use of propofol, reference Diprivan®, and the similar Propovan® during infusion. However, the recovery time was longer with the reference drug. Although analysis of both formulations studied show similar results regarding its physicochemical characterization, further studies should be conducted to justify this difference.
- ItemSomente MetadadadosEfeito analgésico e hipnótico das associações do sufentanil com o tiopental sódico e com propofol, em ratos(Universidade Federal de São Paulo (UNIFESP), 1996) Vieira, Antonio Mauro [UNIFESP]; Fagundes, Djalma José [UNIFESP]
- ItemAcesso aberto (Open Access)Efeitos analgésico e hipnótico das associações do sufentanil com o tiopental e com o propofol, em ratos(Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 1998-04-01) Vieira, Antonio Mauro; Fagundes, Djalma José [UNIFESP]; Bazano, Félix Carlos Ocáriz; Ramos, Eduardo Chibeni Fernandes; Faculdade de Ciências Médicas de Pouso Alegre-MG; Universidade Federal de São Paulo (UNIFESP); Faculdade de Ciências Médicas de Pouso AlegreThe aim of this study was to evaluate the interactions of the analgesic action of sufentanil with the hypnotic action of thiopental and propofol, in 60 male rats distributed in two groups of 30 and submitted to different doses of sufentanil and propofol, to determine the analgesic (AMD) and hypnotic medium doses (HMD). The AMD of sufentanil was the analgesic dose and HMD of thiopental and propofol was the dose to obtain hypnosis, this is, the lost of righting reflex. There was a prolonged hypnotic action when thiopental with sufentanil and propofol with sufentanil were used together. The analgesic action of sufentanil-thiopental association has a significant increase, and sufentanil-propofol association showed no significant difference when compared to sufentanil alone. The sufentanil-thiopental association had more analgesic and hypnotic action when compared to sufentanil-propofol association. When was compared the concomitant presence of analgesy and hypnosis, the sufentanil-thiopental association had a longer lasting.
- ItemSomente MetadadadosO halotano induz estresse oxidativo e ativação do NF-kB em fígado de ratos(Universidade Federal de São Paulo (UNIFESP), 2006) Brasil, Luis Josino [UNIFESP]; Amaral, José Luiz Gomes do [UNIFESP]
- ItemAcesso aberto (Open Access)Interações agudas do chá de ayahuasca com agentes usados em anestesia (propofol e morfina), observadas em modelos animais(Universidade Federal de São Paulo (UNIFESP), 2009-05-27) Pires, Júlia Movilla [UNIFESP]; Amaral, José Luiz Gomes do [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Ayahuasca tea (AYA) is a beverage with psychoactive properties, prepared by the cooking of two plants: Banisteriopsis caapi (Spruce ex Griseb.) C.V. Morton (Malpighiaceae) (stem bark) and the leaves of Psychotria viridis (Ruiz & Pav.) (Rubiaceae). The major hallucinogenic compound present in P. viridis is DMT, but when it is ingested by oral route it is quickly inactivated by MAO-A present in the bowel, which is avoided by the combination of â- carbolines IMAO, present in B. caapi. Despite the constantly increasing use of AYA, there are few studies about the possible interactions produced by this tea in association with other drugs. The aim of this study was to evaluate the possible interactions between AYA and two other drugs used in anesthesia procedures: morphine and propofol; with doses established from the amount ingested by people in the rituals (equivalent of 120 mg/kg). The doses tested varied from 120 mg/kg (1X or 1 dose), to 2400 mg/kg (20X or 20 doses). Concerning pharmacological screening test (PST), AYA showed some signs of toxicity when administered by ip route (decreased of motor activity, hypersensitivity about stimulus and intense tremor). The oral route was better tolerated than ip. Administration of AYA (1X and 10X) did not interfered with motor coordination in the rota-rod test, but AYA 10X showed a biphasic effect on the motor activity test, because it decreased the initial ambulation (until 30 min), followed by an increase between 2h and 4h. AYA 10X increased the sleeping time induced by hexobarbital, however when AYA was administered 24h before hexobarbital did not occurred any interference in the sleeping time. Concerning grooming, the groups treated with AYA 10X showed a decrease of this signs. Results of association of AYA + morphine on the PST, mice showed Straub tail more intense and durable when compared with morphine group and ataxia and tremor when compared with AYA group. In the test of motor coordination, the group treated with the association of drugs, showed a lower motor activity when compared with the morphine group followed by an increase after 2h when compared to the other groups. The results obtained in hot plate test showed a potencialization of the morphine effects; however these results are not confirmed by abdominal contortions and formalin test. Intestinal transit test did not show any results about interaction. To qualitatively evaluate the effect of the association AYA + propofol in the PST, the data showed a potencialization of tremors induced by AYA more intense and durable. In the rota-rod test was observed a diminishing tendency in the AYA + propofol group. On the sleeping time test, AYA 1X decreased the sleeping time induced by propofol. Therefore, AYA interfered with the propofol effects. In summary, the whole results indicate some association interaction among AYA and morphine and propofol. These interactions were subtle and need proper clinical experimentation to verify its occurrence in humans.
- ItemAcesso aberto (Open Access)Propofol e fentanil versus midazolam e fentanil para sedação em pacientes cirróticos durante a realização de endoscopia digestiva alta(Universidade Federal de São Paulo (UNIFESP), 2012-02-22) Correia, Lucianna Motta [UNIFESP]; Libera Junior, Ermelindo Della [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Background: Cirrhotic patients often undergo diagnostic or therapeutic upper gastrointestinal endoscopy. The liver cirrhosis might impair the metabolism of drugs used to sedation due to changes in liver function, with possible consequences for the efficacy and safety during procedures. We designed a study to compare two regimens for sedation during endoscopy in this group of patients: propofol with fentanyl and midazolam with fentanyl. Objectives: To compare the two schemes proposed regarding the sedation efficacy (proportion of complete procedures using the initial proposed scheme), safety (occurrence of sedation-related complications) and recovery time (defined as time between the end of the procedure and ambulatory discharge). Patients and methods: We performed a prospective randomized controlled trial conducted between February 2008 to February 2009. Two hundred and ten cirrhotic outpatients were included and randomized in two groups: Midazolam Group (110 patients, 0.05 mg / kg associated with fentanyl, 50 mg intravenously) and Propofol Group (100 patients, 0.5 mg / kg combined with fentanyl, 50 mg intravenously). Results: There were no differences between groups regarding age, sex, weight, etiology of cirrhosis, classification Child-Pugh or ASA classification, as well as to the type of procedure exam was performed (diagnostic test, band ligation or sclerotherapy for esophageal varices). Sedation with propofol and fentanyl was more efficacious (100% vs. 88.2% - p <0.001) and had a shorter recovery time than sedation with midazolam to fentanyl (16.23 ± 6.84min vs. 27.40 ± 17.19 min, respectively - p <0.001). Complications rate were similar in both groups (14% vs. 7.3% - p = 0.172). Conclusion: Both sedation regimens were safe in this setting. Sedation with propofol and fentanyl was more efficacious and had shorter recovery time when compared to midazolam plus fentanyl. Propofol should be considered as an alternative to sedation during upper GI endoscopy in cirrhotic outpatients.