Navegando por Palavras-chave "Psicose De Retirada"

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    Alterações comportamentais após retirada abruptado tratamento prolongado com clozapina em ratos
    (Universidade Federal de São Paulo (UNIFESP), 2017-10-26) Silva, Neide Derci Da [UNIFESP]; Abílio, Vanessa Costhek [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Background: Treatment of schizophrenia is performed with typical and atypical antipsychotic drugs for long periods of duration, and induces numerous side effects. Clozapine, the gold standard of atypical antipsychotic drugs, is indicated for patients with schizophrenia resistant to other treatments. Nonetheless, clozapine may induce severe side effects, such as agranulocytosis, and in some cases, it is necessary to discontinue treatment. Several reports show that abrupt interruption of antipsychotic treatment produces withdrawal psychosis. However, other effects promoted by withdrawal of an antipsychotic drug – apart from psychosis – are poorly studied in both patients and animal models. Aim: To evaluate the behavioral abnormalities after abrupt withdrawal from a longterm treatment with clozapine, considering dose and duration of deprivation. The acute effects of typical and atypical antipsychotic drugs on these abnormalities were also evaluated. Methods: Male adult Wistar rats (three months old) were treated for 30 days with clozapine (5.0; 10 or 15 mg/kg – i.p.). Seventy-two hours after the last injection, they were submitted to the following behavioral evaluations: 1) social interaction and locomotor activity in the open field arena, 2) pre-pulse inhibition of startle (PPI) and 3) contextual fear conditioning (CFC). In a second series of experiments, rats were treated for 30 days with 10 mg/kg of clozapine and the same behavioral analysis were performed 48, 72 or 96 hours after treatment interruption. In a third series of experiments, we evaluated the acute effects of haloperidol and clozapine on the behavioral changes seen in the two previous experimental situations. Results: 1) 72-hours deprivation of clozapine treatment (10 and 15 mg/kg) increased social interaction, 2) After treatment with clozapine 10 mg/kg, 48 hours of deprivation promoted contextual fear conditioning deficit, and 72 hours of deprivation increased social interaction; 3) Acute administration of haloperidol and clozapine reversed the contextual fear conditioning deficit. Conclusion: Abrupt withdrawal of clozapine induces behavioral abnormalities that depend on the dose and the duration of the withdrawal. The acute effects of antipsychotic drugs on these behavioral alterations vary.