Navegando por Palavras-chave "Pulse wave analysis"

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    Avaliação da velocidade de onda de pulso e da pressão sistólica central em crianças e adolescentes com doença renal crônica
    (Universidade Federal de São Paulo (UNIFESP), 2018-12-04) Brecheret, Ana Paula [UNIFESP]; Sole, Dirceu [UNIFESP]; Fonseca, Francisco Antonio Helfenstein [UNIFESP]; http://lattes.cnpq.br/2393476657163442; http://lattes.cnpq.br/8188258243306974; http://lattes.cnpq.br/3357245869470281; Universidade Federal de São Paulo (UNIFESP)
    Cardiovascular disease remains the most common cause of mortality in chronic kidney disease (CKD). Arterial stiffeness measured by pulse wave velocity (PWV) and central aortic blood pressure (CBP) predicts cardiovascular events and mortality in adults. Defining arterial stiffness may help to determine the cardiovascular risk in children. Objectives: Investigate pulse wave velocity among children and adolescents with CKD. Methods: In this cross-sectional study 57 patients (61.4% male), age 6.2-17.5 years, 44 with non-dialysis CKD and 13 on chronic dialysis were included in the analysis. The PWV and the CBP was measured with an oscillometric device with inbuilt ARCSolver-algorithm (estimated by using the brachial waveform) and compared with previously established percentiles for PWV and CBP. Results: The prevalence of elevated PWV was 21.1% (95%Cl: 11.4-33.9). According to Generalized Linear Model with binomial distribution and log link function there was a higher risk of elevated PWV in patients having chronic dialysis treatment when compared with non-dialysis CKD patients (adjPR=4.31, 95%CI: 1.26-14.83, p=0.020). Hypertensive patients (stage 2) have a higher risk of elevated PWV when compared with normotensives (adjPR=3.11, 95%CI: 1.17-8.24, p=0.022) as the patients younger than 12 years compared with the older patients (adjPR=3.41, 95%CI:1.25-9.29, p=0.017). Hypertensive patients (stage 1 and 2) have higher risk of elevated CBP when compared with normotensives (adjPR=3.29, 95%Cl:1.36-7.94) and patients having chronic dialysis treatment when compared with non-dialysis CKD patients (adjPR=2.08, 95%Cl:1.07-4.02). Conclusions: The findings suggest that younger ages, dialysis and hypertension in children and adolescents are independently associated with an increase in PWV and hypertension and dialysis are independently associated with an increase in CBP. Further research is needed to clarify these relations with cardiovascular complications in children and adolescents with CKD.
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    Efeitos imediatos de um esforço submáximo sobre a velocidade de onda de pulso em pacientes com Síndrome de Marfan
    (Universidade Federal de São Paulo (UNIFESP), 2010-05-26) Peres, Paulo Alberto Tayar [UNIFESP]; Carvalho, Antonio Carlos [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Purpose: Marfan syndrome is a dominant autosomal disease provoked by mutations of gene of fibrillin 1, chromosome 15, and may exhibit skeletal, ocular, cardiovascular and other manifestations. Pulse wave velocity (PWV) is used as a measure of arterial elasticity and rigidity and is related to the elastic properties of the vascular wall. As the practice of exercise is limited in this population, it was of our interest to analyze the acute effect of moderate to intensive exercise on patients with Marfan syndrome with either no dilatation of the aorta or a maximum of mild dilatation of this vessel. Methods: PWV and physiological variables were evaluated before and after the performance of sub-maximal exercise in 33 patients with Marfan syndrome and 18 controls. Results: PWV in the group with Marfan syndrome was 8.51±0.58 m/s at rest and 9.10±0.63 m/s at the end of the exercise (p=0.002); in the control group, PWV was 8.07±0.35 m/s at rest and 8.98±0.56 m/s at the end of exercise (p=0.004). The comparative analysis between groups regarding PWV at rest (p=0.519) and at the end of exercise (p=0.866) revealed no statistically significant differences. The final heart rate values in the control group were 10% higher than values in the group with Marfan syndrome (p = 0.01). Final systolic arterial pressure was higher in the control group (p=0.02). There was no difference in lactate between groups. Exercise time was greater in the control group (p=0.01). Conclusions: The behavior of aortic distensibility was similar in the patients with Marfan syndrome without or with mild dilatation of the aorta to that of the control group. The chronotropic and pressure responses were lower in patients than in control group.