Navegando por Palavras-chave "Rats, inbred SHR"

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    Caracterização Farmacológica da Inibição Pré-Pulso ("Prepulse Inhibition of Startle") na Linhagem SHR (Spontaneously Hypertensive Rats): Possíveis Implicações para Transtornos Psiquiátricos
    (Universidade Federal de São Paulo (UNIFESP), 2009-04-29) Levin, Raquel [UNIFESP]; Abílio, Vanessa Costhek [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Deficits in an operational measure of sensorimotor gating - the prepulse inhibition of startle (PPI) - is presented in psychiatric disorders such as schizophrenia, bipolar disorder, and attention deficit/hyperactivity disorder (ADHD). Some previous studies showed that the spontaneously hypertensive rats (SHR), a putative animal model of ADHD, present deficit in PPI. The aim of the present study was to characterize the deficit in PPI presented by SHR. Adult male normotensive Wistar rats and SHR were submitted to the PPI test. First, we established a protocol able to reveal a deficit in SHR. In sequence, we evaluate the effects of the following drugs administered previously to the PPI test: amphetamine (used for ADHD and also a psychotomimmetic drug), MK-801 (another psychotomimmetic drug), haloperidol and clozapine (antipsychotic drugs), metoclopramide (dopamine antagonist without antipsychotic properties) and carbamazepine (a mood stabilizer). The spontaneous deficit presented by SHR was of same magnitude than that induced by amphetamine or MK-801 in control rats. The antipsychotics (but not metoclopramide or carbamazepine) reversed the deficit observed in SHR. These findings suggest that the deficit in PPI presented by SHR could be a useful animal model to study abnormalities in sensorimotor gating related to schizophrenia.
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    Estudo da função hepática de ratos espontaneamente hipertensos submetidos a diferentes pressões de pneumoperitônio com CO2
    (Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, 2003-01-01) Chida, Valéria Vieira [UNIFESP]; Moreira, Márcia Bento [UNIFESP]; Leme, Luís Fernando Paes [UNIFESP]; Fagundes, Djalma José [UNIFESP]; Ramalho, Carlos Eduardo Benetti [UNIFESP]; Novo, Neil Ferreira [UNIFESP]; Montero, Edna Frasson de Souza [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    PURPOSE: In order to determine the behavior of the hepatic function in spontaneously hipertensive Rats Which underiwent low pressure and high pressure pneumoperitoneum. METHODS: 60 rats were studied two groups of 30 rats, each formed by 15 Wistar EPM-1 and 15 SHR, were subjmitted to 4mmHg and 10mmHg pressure respectively, for 1 hour plus peritoneal pressure normalization time of 1 hour. Immediately after being weighed the rats were given an anesthetic (cetamine and xylazine) intramuscular. Blood samples for hepatic function evaluation were taken immediately after the insertion of a catheter in the left femural artery as well as after 1 hour insufflation and after the one-hour pressure normalization. The significance coeficient was 5 %. RESULTS: Animals submitted to 4mmHg pressure had inicial AST and ALT levels lower than after insuflation and after pressure normalization. DHL, BT and BD levels did not change for both strains. Animals submitte to 10mmHg pressure AST and DHL levels modification for normotensive rats but increased for hypertensive ones; BD did not change; ALT and BT changed for Wistar and SHR. CONCLUSION: Our study shows that pneumoperitoneum has changed the hepatic function of the animals and suggests that one-hour peritoneal pressure normalization seems to be too short to allow hepatic function normalization in both hyper and normotensive animals.
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    Relação estrutura vs. atividade de peptídeos análogos BPP-10c sobre os parâmetros cardiovasculares de ratos espontaneamente hipertensos
    (Universidade Federal de São Paulo (UNIFESP), 2010-12-02) Paschoal, Juliana Fontes Beltran [UNIFESP]; Camargo, Antonio Carlos Martins de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Estudos realizados em nosso laboratório têm mostrado que as ações do BPP-10c (