Navegando por Palavras-chave "Sacarose"
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- ItemSomente MetadadadosEfeito da adrenalectomia e ingestão de sacarose sobre o metabolismo e comportamento alimentar em ratos normais e obesos pelo tratamento com Glutamato Monossódico(Universidade Federal de São Paulo (UNIFESP), 1995) Andrade, Iracema Senna de [UNIFESP]; Dolnikoff, Miriam Sterman [UNIFESP]
- ItemSomente MetadadadosEfeito do aumento da massa corporal na resposta pulmonar e no tecido adiposo em camundongos(Universidade Federal de São Paulo (UNIFESP), 2019-09-05) Escrobat, Ticiana Carvalho Pereira [UNIFESP]; Prado, Carla Máximo [UNIFESP]; http://lattes.cnpq.br/1740478426977844; Universidade Federal de São Paulo (UNIFESP)Introduction: Obesity is a complex syndrome that poses a serious risk to health, and a better understanding of its consequences is necessary. It is known that there is a relationship between obesity and worsening of pulmonary disease, but obesity-induced lung alterations per se have been poorly investigated. Pulmonary inflammation is a pathophysiological characteristic of various diseases such as asthma and COPD (chronic obstructive pulmonary disease). Our hypothesis is that the body mass gain induced by a sucrose-rich diet can, per se, induce inflammatory and morphological changes in the lung. Aim: To evaluate the inflammation and pulmonary morphology of animals submitted to a high caloric high sucrose diet. Methods: Male C57BL/6 mice were submitted to a high caloric high sucrose diet (Obese) or to a standard diet of Nuvilab CR1 (Control). At the end of the protocol, body mass gain, metabolic indexes, visceral adiposity index in the liver and pro and anti-inflammatory cytokines in adipose tissue and liver were evaluated by ELISA. We also evaluated the inflammation (cells and cytokines by ELISA) and morphological alterations in the lung. Results: The animals submitted to the high caloric high sucrose diet had an increase in body mass and visceral adiposity index in the liver compared with control group (p<0.05 and p<0.005, respectively). There was no difference in fasting glycemia between groups, however, animals from obese group showed an increase in the area under the curve in the oral glucose tolerance test and increase in total cholesterol and HDL fraction compared with control (p<0.05). There was no increase in the level of cytokines in epididymal and subcutaneous adipose tissue (TNF-α, IL-6 and IL-10) and in the liver (IL-6 and IL-10) in the obese group. In lung tissue of obese animals, there was an increase in total protein in the lung (p<0.05), in addition to peribronchial edema and increase of polymorphonuclear cells around the airways (p≤0.001 and p<0.05). There was also an increase in bronchoconstriction index (p<0.05), collagen deposition (p<0.05) and increase in smooth muscle thickness in the airways (p<0.05) compared with Control. There was no increase in TNF-α, IL-6, IL-8 and IL-10 in bronchoalveolar lavage, however the concentration of IL-10 in the pulmonary homogenate was reduced in obese animals (p<0.05). Although there has been no increase in cytokines in adipose tissue, there was a positive correlation of gain mass with cytokines IL-6, IL-10 and TNF-α in epididymal adipose tissue (p<0.05). The gain mass also showed a positive correlation with the increase of edema and polymorphonuclear cells around the airways (p<0.05). Also, the increase in cholesterol had a negative correlation with the concentration of IL-10 in the lung tissue, which in turn presented negative correlation with thickening of the muscle layer (p<0.05). Finally, there were correlation between peribronchiolar edema and deposition of collagen fibers with the increase of polymorphonuclear cells and the bronchoconstriction index (p<0.05). Conclusion: The high caloric high sucrose diet induce gain mass without major metabolic and inflammatory changes in adipose tissue. Nevertheless, increased body mass induced significant morphological pulmonary changes, such as bronchoconstriction, edema, increase of polymorphonuclear cells and deposition of collagen fibers in the airways of these animals, which may impair pulmonary function even without causing an increase in cytokines in the lung. These data suggest that obese patients may present greater severity in the pulmonary response when subjected to stress induced by some pathological situation such as asthma or infection.
- ItemSomente MetadadadosEstudo comparativo da frequência de cárie e fatores associados em jovens portadores ou não de diabetes mellitus tipo 1(Universidade Federal de São Paulo (UNIFESP), 2005) Amaral,Fabio Menasce Franco do [UNIFESP]; Ferreira, Sandra Roberta Gouvea [UNIFESP]
- ItemAcesso aberto (Open Access)Estudo da freqüência de cárie e fatores associados no diabetes mellitus tipo 1(Sociedade Brasileira de Endocrinologia e Metabologia, 2006-06-01) Amaral, Fábio Menasce Franco do [UNIFESP]; Ramos, Patrícia G. De A.; Ferreira, Sandra Roberta Gouvea [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)Subjects with diabetes mellitus (DM) are more prone to certain disturbances of oral cavity but there are controversies concerning caries. This cross-sectional study investigated the frequency of caries and associated factors, in a sample of population with or without type 1 DM, including non-diabetic (53 women, 31 men) and 30 diabetic subjects (19 women, 11 men) aged 17-28 years. Diagnosis of dental caries was based on the DMF-T index (D= decay; M= miss; F= fill; T= teeth); in addition, a plaque control record (PCR) was obtained. A preponderance of female sex was found within the groups studied but such proportions did not differ when comparing diabetic and non-diabetic groups. Mean ages were 21.0 ± 2.2 and 19.5 ± 1.8 years, respectively for subjects without and with DM (p< 0.05). Education level was higher in the non-diabetic group as well as the DMF-T index (10.5 ± 5.8 vs. 6.7 ± 5.7, p< 0.01). Linear regression analysis (n= 114) showed significant associations of DMF-T with age, sucrose intake, daily frequency of tooth brushing, of dental floss use, PCR and of visits to the dentist. By ANOVA model with age as a covariate the non-diabetic condition (p= 0.047), sucrose index and PCR (r²= 0.820) were independently associated with the DMF-T. In the diabetic-specific model, with only the diabetic subjects included and sucrose index as a covariate, DM duration, fundus abnormality and PCR were significantly associated with the presence of caries (r²= 0.816). The sample of type 1 diabetic subjects suggest that they are less prone to caries than non-diabetics, despite having a higher frequency of meals, less tooth brushing and dental floss use. We speculate that DM duration may contribute to the occurrence of caries and restricted sucrose consumption to lower frequency of caries in diabetic subjects.
- ItemSomente MetadadadosFerimentos padronizados tratados por papaina, acucar, minoxidil e glucana, em ratos(Universidade Federal de São Paulo (UNIFESP), 1991) Smialowski, Elizabeth Brenda [UNIFESP]
- ItemSomente MetadadadosIntrodução da sacarose no plano alimentar de portadores de diabetes mellitus tipo 1(Universidade Federal de São Paulo (UNIFESP), 2003) Costa, Paula Cristina Augusto da [UNIFESP]; Franco, Laercio Joel [UNIFESP]Introdução: O uso de carboidratos na alimentacao do diabetico tem sido debatido continuamente, varias pesquisas demonstraram que o importante e a quantidade total de carboidratos consumido e nao a sua origem. Objetivo: Avaliar a influencia da Introdução da sacarose no controle glicemico de adolescentes diabeticos. Metodos: Participaram deste estudo 10 adolescentes diabeticos sem complicacao secundaria ao diabetes, de ambos os sexos, que sao atendidos no Centro de Diabetes da UNIFESP - EPM. Inicialmente, os pacientes foram acompanhados, individualmente, com orientacao alimentar, ajuste da dose de insulina e realizacao de monitorizacao domiciliar da glicemia durante quatro meses. A partir do quarto mes, foi mantida a monitorizacao domiciliar da glicemia e a orientacao alimentar individualizada, porem com Introdução do consumo de sacarose no lanche vespertino, durante mais quatro meses. Foi coletada amostra de sangue, na condicao de jejum, para dosagem de colesterol total e triglicerides no inicio e no final do estudo e para dosagem da hemoglobina glicada no inicio, apos quatro meses sem consumo de sacarose e apos quatro meses com consumo de sacarose. A analise estatistica foi realizada por meio dos softwares Epi Info 6.0 e Sigma Stat 2.0. Resultados e Discussao: Os resultados mostraram que a adesao do adolescente diabetico ao tratamento proposto esta diretamente relacionado ao conhecimento que este tem sobre a doenca. Apos quatro meses de acompanhamento, reduziram a realizacao da monitorizacao domiciliar (p<0,001). Mesmo nao apresentando controle metabolico ideal, estes adolescentes apresentavam desenvolvimento puberal e crescimento adequados. Todos apresentaram valores sericos de colesterol total e triglicerides dentro da normalidade. Os valores da hemoglobina glicada diminuiram durante o periodo de seguimento, com diferenca significante entre o inicio e o final do estudo (p=0,027). Nao houve diferenca com significancia estatistica entre os valores do perfil glicemico antes e apos a inclusao da sacarose. Conclusao: A tecnica de contagem de gramas de carboidratos foi bem aceita e o consumo de alimentos com sacarose, nao comprometeu o controle metabolico dos adolescentes do estudo
- ItemAcesso aberto (Open Access)Introdução da sacarose no plano alimentar de portadores de diabetes mellitus tipo 1: sua influência no controle glicêmico(Sociedade Brasileira de Endocrinologia e Metabologia, 2005-06-01) Costa, Paula Cristina A. da [UNIFESP]; Franco, Laercio Joel [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)To evaluate the influence of sucrose intake in the glycemic control, ten adolescents with type 1 diabetes were followed during eight months. Initially, they received personalized orientation on diet, self monitoring blood glucose and insulin dose adjustment; after four months, all patients introduced sucrose in their afternoon meals, throught the method of carbohydrate counting. Total cholesterol and triglycerides levels were measured in the beginning and in the final of the study. Hemoglobin A1C levels were measured in the beginning, after four months without and after four months with intake of foods with sucrose. All patients showed adequate pubertal development and growth; two had overweight and the others were eutrophic. After four mounths of follow up, the frequency of self monitoring blood glucose was reduced (p< 0.001). Total cholesterol and triglycerides values were in the normal range and A1C values decreased during the observed period (p= 0.027). Conclusion: the consumption of foods with sucrose, using the technique of carbohydrate counting, did not affect the metabolic control of adolescents with type 1 diabetes.
- ItemSomente MetadadadosRemoção de lecitina de óleo bruto de soja por adsorção em sacarose(Universidade Federal de São Paulo (UNIFESP), 2020-12-16) Rodrigues, Ana Amelia De Lurdes Coelho [UNIFESP]; Bresolin, Igor Tadeu Lazzarotto [UNIFESP]; Universidade Federal de São PauloDegumming is the first stage on the refining process of vegetable oil. It consists in extraction operation that aims to remove the gum present in the crude oil. This is an important step that prevents the formation of sludge, oil rancidity and oxidation, among other negative effects throughout the refining process. The objective of this work was to investigate a possible alternative method for removing lecithin from vegetable oils, a process known as degumming. The study was based on the use of sucrose as a lecithin adsorbent material. The current methods employed are wet degumming and acid degumming, which consist of adding water or a mixture of water and acid to the crude oil, respectively, which can negatively contribute to the quality of the oil and the extracted lecithin. As a result, it is interesting to develop an alternative method of degumming, which presents satisfactory performance, does not use water and acids, does not generate residue and which is energy efficient. For this purpose, the characteristics of the sugar were determined, such as porosity and granulometry, the kinetic and balance data was collected, intending to obtaining an oil with a lower lecithin content and a by-product with high commercial potential. It was found that the lower the mass of sucrose, the greater the adsorption capacity of lecithin. The highest removal yield obtained was 26.50% when using the mass of 1 gram of sucrose, which is equivalent to the removal capacity of 798 mg of lecithin per gram of sucrose. The greatest removal capacity was 2952 mg of lecithin per grams of sucrose when using 0.01 gram of sucrose. With this study it was possible to prove the adsorption capacity of lecithin in sucrose. However, isothermal adsorption models do not predict their behavior under the conditions of analysis, which can be justified by the nonporosity of sucrose.
- ItemSomente MetadadadosUso topico do acucar em ferida cutanea: estudo experimental em rato(Universidade Federal de São Paulo (UNIFESP), 1987) Prata, Marcos Bittencourt [UNIFESP]