Navegando por Palavras-chave "Stomatitis"
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- ItemAcesso aberto (Open Access)Efeitos da glicina na mucosite oral induzida por 5-fluorouracil em hamster(Universidade Federal de São Paulo (UNIFESP), 2010-07-28) Sá, Odara Maria de Sousa [UNIFESP]; Caran, Eliana Maria Monteiro [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Mucosite oral é complicação comum no tratamento do câncer. A glicina demonstra efeito antiinflamatório, imunomodulador e citoprotetor. Este estudo tem como objetivo avaliar os efeitos da suplementação de glicina na reparação da mucosite oral induzida por 5-fluorouracil em hamster. Os animais foram divididos em dois grupos: grupo experimental (GI; n=20) e grupo controle (GII; n=20) ambos receberam injeção intraperitoneal de 5-fluorouracil no 1° e 3° dia. Os animais tiveram a sua bolsa jugal direita evertida e arranhada superficialmente no dia 3. O Grupo I, foi submetido ao tratamento com glicina a 5% por infusão intraperitoneal durante 7 dias e o Grupo II, recebeu placebo. A mucosa do GI e GII foi avaliada clinicamente, por meio de escore, no D3 e D7. Ao final do experimento a bolsa jugal dos animais de ambos os grupos foi retirada e avaliada segundo parâmetros histopatológicos e bioquímicos. Os grupos I e II apresentaram acentuado processo inflamatório durante o período inicial, segundo a avaliação clínica. No GI houve redução da severidade da mucosite, diminuição do processo inflamatório, cicatrização acelerada e redução da peroxidação lipídica quando comparado ao GII no final do experimento (p < 0,001). A suplementação com glicina demonstrou ser promissor instrumento para tratamento da mucosite, devido aos seus efeitos no processo inflamatório. Palavras chaves: Glicina; Estomatite; Fluoruracila; Cricetulus.
- ItemAcesso aberto (Open Access)Efeitos da glicina nas expressões imunohistoquimicas de PDGF, FGF e EGF em mucosite oral induzita em hamster(Universidade Federal de São Paulo (UNIFESP), 2017-12-08) Sá, Odara Maria de Sousa [UNIFESP]; Caran, Eliana Maria Monteiro [UNIFESP]; Alves, Maria Teresa de Seixas [UNIFESP]; Lopes, Nilza Nelly Fontana [UNIFESP]; Maria Teresa de Seixas Alves : http://lattes.cnpq.br/0357765137541523; Nilza Nelly Fontana Lopes : http://lattes.cnpq.br/8672330651019555; http://lattes.cnpq.br/1783139918188371; http://lattes.cnpq.br/3916790331038294; Universidade Federal de São Paulo (UNIFESP)Introduction: Oral mucositis is one of the most frequent toxic effects of chemotherapeutic and/or radiotherapeutic treatment, resulting from complex multifaceted biological events involving DNA damage, multiple signaling, and interactions between epithelial, submucosal, and connective tissue. Clinical manifestations such as pain, difficulty in swallowing and communication, and infections have a negative impact on the tolerance to treatment and the quality of life of cancer patients. Preventive measures and curative treatment of mucositis, secondary to chemotherapy and radiotherapy, are still not well established, requiring cooperative studies and new synchronic and effective therapeutic approaches. On the other hand, the nonessential amino acid glycine has anti-inflammatory, immunomodulatory and cytoprotective action, being a potential therapeutic option in mucositis. Therefore, we performed this study with the objective of evaluating the effects of glycine on the expression of collagen and growth factors, platelet (PDGF) and epidermal (EGF), in experimental models of oral mucositis, as apoptotic markers. Methods: The biological material used was the hamster jugal mucosa. The mucositis of which was induced by the protocol proposed by Sonis. A total of 40 hamsters were used, divided into two groups: group I (n= 20)- control; Group II (n= 20) supplemented with 5% intraperitoneal glycine, 0,2 ml (2,0 mg /g) diluted in herpes . On day 7 histopathological sections were performed in order to perform the immune-histochemical method, the evaluation of quantitative and qualitative collagen expression by means of picrossirius under polarized light and the growth factors: EGF and PDGF. Results: It was observed that the group supplemented with glycine higher amounts of collagen expression and predominance type of collagen I when compared to the compared to the control group (p≤0.0002). The glycine group presented lower immunoexpression (p≤0,0001) of the growth factors, EGF and PDGF in relation to the control group. The animals that expressed type I collagen fibers, independent of the experimental group, presented higher amount of collagen and less immunoexpression of the growth factors: EGF and PDGF. Conclusion: The group supplemented with glycine showed a marked healing process of the oral mucosite, demonstrated by the predominance of collagen type I and reduction of growth factors, EGF and PDGF.
- ItemAcesso aberto (Open Access)Tratamento da mucosite em pacientes submetidos a transplante de medula óssea: uma revisão sistemática(Escola Paulista de Enfermagem, Universidade Federal de São Paulo (UNIFESP), 2011-01-01) Ferreira, Patrícia; Gamba, Mônica Antar [UNIFESP]; Saconato, Humberto; Gutiérrez, Maria Gaby Rivero de [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Rio Grande do NorteOBJECTIVE: To identify therapeutic measures to reduce the severity of oral mucositis in adult patients undergoing bone marrow transplantation (BMT). METHODS: A systematic review using the following databases: LILACS, MEDLINE, CINAHL, EMBASE, CENTRAL (Cochrane Central) and DARE (Database of abstracts of reviews of effects), for the period between 1972 to July 2010, using the key words mucositis, stomatitis and bone marrow transplantation. RESULTS: We identified 3,839 abstracts, 22 of which were included in the systematic review; these articles identified 14 topical and systemic interventions, among which eight showed statistical significance for the reduction of this complication. The topical therapies were: cryotherapy, chlorhexidine, glutamine, laser and Traumeel ®. The systemic therapies were: amifostine, Granulokine ®, and palifermin. CONCLUSION: The heterogeneity of the results of these interventions and the lack of better elucidation for healthcare practice indicate the need for more accurate research to identify the effectiveness of topical therapies for repair of mucosal cells.