Navegando por Palavras-chave "Test"

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    Non-flat audiograms in sensorineural hearing loss and speech perception
    (Faculdade de Medicina / USP, 2013-06-01) Andrade, Kelly Cristina Lira de; Menezes, Pedro de Lemos; Carnaúba, Aline Tenório Lins; Rodrigues, Renato Glauco de Sousa; Leal, Mariana de Carvalho; Pereira, Liliane Desgualdo [UNIFESP]; Universidade Federal de Pernambuco Fonoaudiologia; Universidade Estadual de Ciências da Saúde de Alagoas; Universidade Federal do Rio Grande Física; Universidade Federal de São Paulo (UNIFESP)
    OBJECTIVE: The audibility thresholds for the sound frequency of 137 upward- and downward-sloping audiograms showing sensorineural hearing loss were selected and analyzed in conjunction with speech recognition thresholds obtained from individuals seen at a public otolaryngology clinic to determine which frequencies in slope audiograms best represent speech recognition thresholds. METHOD: The linear regression model and mean square error were used to determine the associations between the threshold values. RESULT: The mean square error identified larger errors when using thresholds of 500, 1000, and 2000 Hz than when using audibility thresholds of 500, 1000, 2000, and 4000 Hz. The linear regression model showed a higher correlation (91%) between the audiogram thresholds for frequencies of 500, 1000, 2000, and 4000 Hz than for the frequencies of 500, 1000, and 2000 Hz (88%). CONCLUSION: Frequencies of 500, 1000, 2000, and 4000 Hz were the most significant in predicting the speech recognition threshold.
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    Staying at the crossroads: assessment of the potential of serum lithium monitoring in predicting an ideal lithium dose
    (Associação Brasileira de Psiquiatria - ABP, 2008-09-01) Lima, Thiago Zaqueu de [UNIFESP]; Blanco, Miriam Marcela [UNIFESP]; Santos-Junior, Jair Guilherme [UNIFESP]; Coelho, Carolina Tesone [UNIFESP]; Mello, Luiz Eugenio Araujo de Moraes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    OBJECTIVE: Lithium has been successfully employed to treat bipolar disorder for decades, and recently, was shown to attenuate the symptoms of other pathologies such as Alzheimer's disease, Down's syndrome, ischemic processes, and glutamate-mediated excitotoxicity. However, lithium's narrow therapeutic range limits its broader use. Therefore, the development of methods to better predict its dose becomes essential to an ideal therapy. METHOD: the performance of adult Wistar rats was evaluated at the open field and elevated plus maze after a six weeks treatment with chow supplemented with 0.255%, or 0.383% of lithium chloride, or normal feed. Thereafter, blood samples were collected to measure the serum lithium concentration. RESULTS: Animals fed with 0.255% lithium chloride supplemented chow presented a higher rearing frequency at the open field, and higher frequency of arms entrance at the elevated plus maze than animals fed with a 50% higher lithium dose presented. Nevertheless, both groups presented similar lithium plasmatic concentration. DISCUSSION: different behaviors induced by both lithium doses suggest that these animals had different lithium distribution in their brains that was not detected by lithium serum measurement. CONCLUSION: serum lithium concentration measurements do not seem to provide sufficient precision to support its use as predictive of behaviors.