Navegando por Palavras-chave "Ulcerative rectocolitis"

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    Artrite enteropática no Brasil: dados do registro brasileiro de espondiloartrites
    (Sociedade Brasileira de Reumatologia, 2013-12-01) Resende, Gustavo Gomes; Lanna, Cristina Costa Duarte; Bortoluzzo, Adriana Bruscato; Gonçalves, Célio Roberto; Silva, José Antonio Braga da; Ximenes, Antônio Carlos; Bertolo, Manoel Barros; Ribeiro, Sandra Lúcia Euzébio [UNIFESP]; Keiserman, Mauro Waldemar; Menin, Rita; Skare, Thelma Larocca; Carneiro, Sueli Coelho da Silva; Azevedo, Valderílio Feijó; Vieira, Walber Pinto; Albuquerque, Elisa Martins das Neves de; Bianchi, Washington Alves; Bonfiglioli, Rubens; Campanholo, Cristiano; Carvalho, Hellen Mary da Silveira de; Costa, Izaias Pereira da; Duarte, Angela Luzia Branco Pinto [UNIFESP]; Kohem, Charles Lubianca; Leite, Nocy Honorato; Lima, Sonia Anti Loduca; Meirelles, Eduardo de Souza; Pereira, Ivânio Alves; Pinheiro, Marcelo de Medeiros [UNIFESP]; Polito, Elizandra; Rocha, Francisco Airton Castro da; Santiago, Mittermayer Barreto; Sauma, Maria de Fátima Lobato da Cunha; Valim, Valeria [UNIFESP]; Sampaio-Barros, Percival Degrava; Universidade Federal de Minas Gerais; Instituto Insper de Educação e Pesquisa; Universidade de São Paulo (USP); Universidade de Brasília; Hospital Geral de Goiânia; Universidade Estadual de Campinas (UNICAMP); Universidade Federal do Amazonas; Pontifícia Universidade Católica; Faculdade de Medicina de São José do Rio Preto; Hospital Evangélico de Curitiba; Universidade Federal do Rio de Janeiro; Universidade Federal do Paraná; Hospital Geral de Fortaleza; Universidade Estadual do Rio de Janeiro; Santa Casa do Rio de Janeiro; Santa Casa de São Paulo; Hospital de Base; Universidade Federal do Mato Grosso do Sul; Universidade Federal de Pernambuco; Universidade Federal do Rio Grande do Sul; Faculdade de Medicina Souza Marques; Hospital do Servidor Público Estadual; Universidade Federal de Santa Catarina; Universidade Federal de São Paulo (UNIFESP); Santa Casa de Belo Horizonte; Universidade Federal do Ceará; Escola de Medicina e Saúde Pública; Universidade Federal do Pará; Universidade Federal do Espírito Santo
    Inflammatory bowel diseases (Crohn's disease and ulcerative rectocolitis) have extraintestinal manifestations 25% of the patients, with the most common one being the enteropathic arthritis. METHODS: Prospective, observational, multicenter study with patients from 29 reference centers participating in the Brazilian Registry of Spondyloarthritis (RBE), which incorporates the RESPONDIA (Ibero-American Registry of Spondyloarthritis) group. Demographic and clinical data were collected from 1472 patients and standardized questionnaires for the assessment of axial mobility, quality of life, enthesitic involvement, disease activity and functional capacity were applied. Laboratory and radiographic examinations were performed. The aim of this study is to compare the clinical, epidemiological, genetic, imaging, treatment and prognosis characteristics of patients with enteropathic arthritis with other types of spondyloarthritis in a large Brazilian cohort. RESULTS: A total of 3.2% of patients were classified as having enteroarthritis, 2.5% had spondylitis and 0.7%, arthritis (peripheral predominance). The subgroup of individuals with enteroarthritis had a higher prevalence in women (P < 0.001), lower incidence of inflammatory axial pain (P < 0.001) and enthesitis (P = 0.004). HLA-B27 was less frequent in the group with enteroarthritis (P = 0.001), even when considering only those with the pure axial form. There was a lower prevalence of radiographic sacroiliitis (P = 0.009) and lower radiographic score (BASRI) (P = 0.006) when compared to patients with other types of spondyloarthritis. They also used more corticosteroids (P < 0.001) and sulfasalazine (P < 0.001) and less non-steroidal anti-inflammatory drugs (P < 0.001) and methotrexate (P = 0.001). CONCLUSION: There were differences between patients with enteroarthritis and other types of spondyloarthritis, especially higher prevalence of females, lower frequency of HLA-B27, associated with less severe axial involvement.
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    Clinical-pathological and p53 protein expression study in dysplasia associated with ulcerative colitis
    (Sociedade Brasileira de Coloproctologia, 2014-09-01) Baldin Júnior, Antônio; Telles, José Ederaldo Queiroz [UNIFESP]; Bonardi, Renato De Araújo; Amarante, Heda Maria Barska Dos Santos; Baldin, Rosimeri Kuhl Svoboda; Universidade Federal do Paraná (UFPR); Universidade Federal do Paraná (UFPR) Hospital de Clínicas Coloproctology Unit; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Paraná (UFPR) Hospital de Clínicas; Universidade Federal do Paraná (UFPR) Department of Clinical Pathology; Universidade Federal do Paraná (UFPR) Department of Surgery; Universidade Federal do Paraná (UFPR) Department of Internal Medicine
    Background: The association between ulcerative colitis and adenocarcinoma determined strategies for patient follow-up and early detection of dysplastic and neoplastic lesions. Aims: To analyze the incidence of dysplasia in patients with ulcerative colitis, comparing clinical data of patients with and without dysplasia and check immunohistochemical expression of p53 protein in dysplasias. Materials and methods: We analyzed biopsy samples and clinical data of 124 patients with ulcerative colitis at Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil. Results: Dysplasia incidence was low (9.67%) and all cases with low-grade dysplasia. Patients clinical data comparison with and without dysplasia did not show significant statistical differences with regard to the race, age at the start of the disease, age at last biopsy, duration and anatomic extent of ulcerative colitis. Significant difference was found between males and females with predominance of males (58.34%) for dysplasia. Seventeenth biopsy samples of 12 patients with dysplasia, 5 (29.4%) were p53 positive. Conclusions: From these results it is concluded that the incidence of dysplasia was low, higher in males and there was positivity of p53 protein in dysplasia.