Navegando por Palavras-chave "Vitamin D Deficiency"

Agora exibindo 1 - 2 de 2
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    Atopic dermatitis and vitamin D: facts and controversies
    (Soc Brasileira Dermatologia, 2013-11-01) Mesquita, Kleyton de Carvalho; Igreja, Ana Carolina de Souza Machado; Costa, Izelda Maria Carvalho [UNIFESP]; Universidade de Brasília (UnB); Fed Dist Hlth State Dept SES DF; Universidade Federal de São Paulo (UNIFESP)
    Patients with atopic dermatitis have genetically determined risk factors that affect the barrier function of the skin and immune responses that interact with environmental factors. Clinically, this results in an intensely pruriginous and inflamed skin that allows the penetration of irritants and allergens and predisposes patients to colonization and infection by microorganisms. Among the various etiological factors responsible for the increased prevalence of atopic diseases over the past few decades, the role of vitamin D has been emphasized. As the pathogenesis of AD involves a complex interplay of epidermal barrier dysfunction and dysregulated immune response, and vitamin D is involved in both processes, it is reasonable to expect that vitamin D's status could be associated with atopic dermatitis' risk or severity. Such association is suggested by epidemiological and experimental data. in this review, we will discuss the evidence for and against this controversial relationship, emphasizing the possible etiopathogenic mechanisms involved.
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Status Da Vitamina D E Repercussão Na Modulação Da Via Do Nf-"B Na Placenta E Nos Parâmetros Clínicos E Antropométricos Neonatais
    (Universidade Federal de São Paulo (UNIFESP), 2018-03-23) Momentti, Ana Carolina [UNIFESP]; Pisani, Luciana Pellegrini [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Background. Vitamin D has been widely recognized for its role in modulating inflammation and immune system, being associated with placental inflammatory process, and fetal and neonatal clinical complications, but it still to be more elucidated. Aim. To investigate the possible changes in the placental inflammatory parameters induced by insufficient and deficient maternal vitamin D status in relation to the adequate status, and the repercussion in the clinical and anthropometric neonatal parameters. Methods. Puerperal women with single fetus without obstetric pathologies and/or complications were recruited to study. Serum 25(OH)D was measured in the first 48 hours after delivery, and the participants were classified according to vitamin D status: AD - adequate vitamin D status (control group); INS - insufficient vitamin D status; DEF - deficient vitamin D status. The placenta was collected after delivery. Maternal and neonatal data were obtained in the participants’ medical records. TNF- α, IL-10, MCP-1 and IL-10/TNF-α ratio protein contents and phosphorylated subunit of NF-κB p50 and TNFR1 protein expression were determined in placenta by ELISA and Western Blotting, respectively. Results. Vitamin D status demonstrated no association with placental inflammatory and neonatal parameters. A positive correlation (r= 0.03; p<0.05) was observed between maternal serum 25(OH)D and calcium. Conclusion. Our results do not exclude the possibility of maternal vitamin D inadequacy having influence on the development of future adverse events especially on the offspring. Further researches are needed to improve understanding of the determinants and the impacts of immunologic transition on the maternal-fetal dyad in a normal pregnancy.