Navegando por Palavras-chave "Voxel-based morphometry"
- ItemSomente MetadadadosAuras and clinical features in temporal lobe epilepsy: A new approach on the basis of voxel-based morphometry(Elsevier B.V., 2010-05-01) Castilho Garcia Santana, Maria Teresa [UNIFESP]; Jackowski, Andrea Parolin [UNIFESP]; Silva, Henrique Hattori da [UNIFESP]; Sales Ferreira Caboclo, Luis Otavio [UNIFESP]; Centeno, Ricardo Silva [UNIFESP]; Bressan, Rodrigo A. [UNIFESP]; Carrete, Henrique [UNIFESP]; Targas Yacubian, Elza Marcia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)MRI investigations in patients with temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) have demonstrated structural abnormalities extending beyond ipsilateral hippocampus which may be studied through voxel-based morphometry (VBM). We investigated brain morphology related to clinical features in patients with refractory TLE with MIS using VBM. One hundred patients with unilateral TLE with MTS (59 left) and 30 controls were enrolled. VBM5 was employed to analyze (1) hemispheric damage, (2) influence of initial precipitating injury (IPI): 23 patients with febrile seizures and 19 with status epilepticus, and (3) types of auras classified as: mesial, including psychic auras (19 patients); anterior mesio-lateral, as autonomic symptoms, specially epigastric auras (27 patients) and neocortical, which included auditory, vertiginous, somatosensory and visual auras (16 patients). (1) Left TLE patients presented more widespread gray matter volume (GMV) reductions affecting ipsilateral hippocampus, temporal neocortex, insula and also left uncus, precentral gyrus, thalamus, parietal lobule, cuneus and bilateral cingulum. (2) Febrile seizures group presented ipsilateral GMV reductions in hippocampus, neocortical temporal, frontal and occipital cortices, insula and cingulum. Status epilepticus group presented more widespread GMV reductions involving temporal and amygdala, particularly right TLE group, who presented greater extension of GMV reduction in the entorhinal cortex. Significant reductions in hippocampus, amygdala and insula were seen in patients with anterior mesio-lateral auras. This study evaluated a large number of TLE-MTS patients showing structural damage extending beyond hippocampus, and different types of IPI associated with the extension of brain damage. Subtypes of auras are related to different clusters of areas of GMV reductions in VBM. for the first time, we have demonstrated GMV reductions anatomically correspondent to psychic (mesial areas) and autonomic auras (mesial and insular areas) reproducing previous cortical stimulation studies. (C) 2010 Elsevier B.V. All rights reserved.
- ItemSomente MetadadadosGamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective study(Elsevier B.V., 2008-12-12) Cecconia, Janaina Philippi; Lopes, Antonio Carlos; Duran, Fabio Luis de Souza; Santos, Luciana Cristina; Hoexter, Marcelo Queiroz [UNIFESP]; Gentil, Andre Felix; Canteras, Miguel Montes; Castro, Claudio Campi de; Noren, George; Greenberg, Benjamin D.; Rauch, Scott L.; Busatto, Geraldo F.; Miguel, Euripedes Constantino; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP); Hosp Santa Paula; Brown Univ; Harvard Univ; Massachusetts Gen HospObjective: the purpose of this study was to investigate regional structural abnormalities in the brains of five patients with refractory obsessive-compulsive disorder (OCD) submitted to gamma ventral capsulotomy. Methods: We acquired morphometric magnetic resonance imaging (MRI) data before and after 1 year of radiosurgery using a 1.5-T MRI scanner. Images were spatially normalized and segmented using optimized voxel-based morphometry (VBM) methods. Voxelwise statistical comparisons between pre- and post-surgery MRI scans were performed using a general linear model. Findings in regions predicted a priori to show volumetric changes (orbitofrontal cortex, anterior cingulate gyrus, basal ganglia and thalamus) were reported as significant if surpassing a statistical threshold of p<0.001 (uncorrected for multiple comparisons). Results: We detected a significant regional postoperative increase in gray matter volume in the right inferior frontal gyri (Brodmann area 47, BA47) when comparing all patients pre and postoperatively. Conclusions: Our results support the current theory of frontal-striatal-thalamic-cortical (FSTC) circuitry involvement in OCD pathogenesis. Gamma ventral capsulotomy is associated with neurobiological changes in the inferior orbitofrontal cortex in refractory OCD patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
- ItemAcesso aberto (Open Access)Gender and hemispheric differences in temporal lobe epilepsy: A VBM study(W B Saunders Co Ltd, 2014-04-01) Santana, Maria Teresa Castilho Garcia de [UNIFESP]; Jackowski, Andrea Parolin [UNIFESP]; Britto, Fernanda dos Santos [UNIFESP]; Sandim, Gabriel Barbosa [UNIFESP]; Caboclo, Luís Otávio Sales Ferreira [UNIFESP]; Centeno, Ricardo Silva [UNIFESP]; Carrete Junior, Henrique [UNIFESP]; Yacubian, Elza Márcia Targas [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Purpose: Gender differences are recognized in the functional and anatomical organization of the human brain. Differences between genders are probably expressed early in life, when differential rates of cerebral maturation occur. Sexual dimorphism has been described in temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). Several voxel-based morphometry (VBM) studies have shown that TLE-MTS extends beyond mesial temporal structures, and that there are differences in the extent of anatomical damage between hemispheres, although none have approached gender differences. Our aim was to investigate gender differences and anatomical abnormalities in TLE-MTS.Methods: VBM5 was employed to analyze gender and hemispheric differences in 120 patients with TLE-MTS and 50 controls.Results: VBM abnormalities were more widespread in left-TLE; while in women changes were mostly seen in temporal areas, frontal regions were more affected in men.Conclusions: Our study confirmed that gender and laterality are important factors determining the nature and severity of brain damage in TLE-MTS. Differential rates of maturation between gender and hemispheres may explain the distinct areas of anatomical damage in men and women. (C) 2013 British Epilepsy Association. Published by Elsevier B.V. All rights reserved.
- ItemSomente MetadadadosPersonality traits related to juvenile myoclonic epilepsy: MRI reveals prefrontal abnormalities through a voxel-based morphometry study(Elsevier B.V., 2009-06-01) Araujo Filho, Gerardo Maria de [UNIFESP]; Jackowski, Andrea Parolin [UNIFESP]; Lin, Katia [UNIFESP]; Guaranha, Mirian S. B. [UNIFESP]; Guilhoto, Laura M. F. F. [UNIFESP]; Silva, Henrique Hattori da [UNIFESP]; Sales Ferreira Caboclo, Luis Otavio [UNIFESP]; Carrete Junior, Henrique [UNIFESP]; Bressan, Rodrigo Affonseca [UNIFESP]; Yacubian, Elza Márcia Targas [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Studies involving juvenile myoclonic epilepsy (JME) patients have demonstrated an elevated prevalence of cluster B personality disorders (PD) characterized as emotional instability, immaturity, unsteadiness, lack of discipline, and rapid mood changes. We aimed to verify a possible correlation between structural brain abnormalities in magnetic resonance image (MRI) and the PD in JME using voxel-based morphometry (VBM). Sixteen JME patients with cluster B PD, 38 JME patients without psychiatric disorders, and 30 healthy controls were Submitted to a psychiatric evaluation through SCID I and II and to a MRI scan. Significant reduction in thalami and increase in mesiofrontal and frontobasal regions' volumes were observed mainly in JME patients with PD. Structural alterations of the orbitofrontal cortex (OFC), involved in regulation of mood reactivity, impulsivity, and social behavior, were also observed. This study supports the hypothesis of frontobasal involvement in the pathophysiology of cluster B PD related to JME. (C) 2009 Elsevier Inc. All rights reserved.
- ItemSomente MetadadadosVoxel-based morphometry evaluation of patients with photosensitive juvenile myoclonic epilepsy(Elsevier B.V., 2009-10-01) Lin, Katia [UNIFESP]; Jackowski, Andrea Parolin [UNIFESP]; Carrete Junior, Henrique [UNIFESP]; Araujo Filho, Gerardo Maria de [UNIFESP]; Silva, Henrique Hattori [UNIFESP]; Bittar Guaranha, Mirian Salvadori [UNIFESP]; Figueiredo Ferreira Guilhoto, Laura Maria [UNIFESP]; Bressan, Rodrigo Affonseca [UNIFESP]; Targas Yacubian, Elza Marcia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)We aim to investigate structural brain abnormalities in juvenile myoclonic epilepsy (JME) patients with photosensitivity (PS). Sixty JME patients, 19 (32%) of whom were photosensitive, were submitted to 1.5 T magnetic resonance voxel-based morphometry (VBM). the control group (CTL) consisted of 30 sex-matched healthy volunteers. JME patients with (JME-PS) and without (JME-NPS) PS did not differ in their duration of disease, treatment or seizure control. VBM revealed significantly reduced bilateral gray matter volume (GMV) in thalami, insula cortices and cerebellar hemispheres; while significantly increased GMV was observed in the right superior frontal, orbitofrontal and medial. frontal gyri of the JME group compared to CTL. JME-PS had reduced bilateral GMV of visual cortices when compared with CTL; white it was not seen among JME-NPS patients. Reduced left hippocampus and left inferior frontal gyrus volume was observed among JME-PS compared with JME-NPS. This study demonstrates structural abnormalities beyond the limits of the frontal lobes and provides evidence for the role of the occipital cortex in human PS, reinforcing the existence of functional-anatomic ictogenic networks in JME and the concept of 'system epitepsies'. (C) 2009 Elsevier B.V. All rights reserved.