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- ItemAcesso aberto (Open Access)Caracterização clínica e histopatológica e tipagem do papilomavírus humano das verrugas vulgares nos receptores de transplante renal(Sociedade Brasileira de Dermatologia, 2010-10-01) Martelli-Marzagão, Flavia [UNIFESP]; Yamashiro, Alberto Shodi [UNIFESP]; Ogawa, Marilia Marufuji [UNIFESP]; Santos Jr, Gildo Francisco dos; Tomimori, Jane [UNIFESP]; Porro, Adriana Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Associação Fundo de Incentivo à PsicofarmacologiaThe prevalence of skin lesions caused by the human papillomavirus (HPV) is high in kidney transplant patients. Twenty recipients of kidney transplants with a diagnosis of common warts were evaluated. HPV detection was performed by polymerase chain reaction (PCR) using the MY09/MY11 and RK91 primers. HPV typing was performed by restriction fragment length polymorphism analysis and direct sequencing. The presence of HPV was identified in 10 patients (50%) and the types identified were HPV-2, 27, 29, 34 and 57.
- ItemAcesso aberto (Open Access)Infecção pelo papilomavírus humano: etiopatogenia, biologia molecular e manifestações clínicas(Sociedade Brasileira de Dermatologia, 2011-04-01) Leto, Maria das Graças Pereira; Santos Júnior, Gildo Francisco dos; Porro, Adriana Maria [UNIFESP]; Tomimori, Jane [UNIFESP]; AFIP Medicina Laboratorial; Universidade Federal de São Paulo (UNIFESP)Human papillomavirus (HPV) is a DNA virus that presents tropism for epithelial cells, causing infections of the skin and mucous membranes. Replication of HPV occurs in the nuclei of squamous cells and its life cycle is directly related to the differentiation program of the host cell. To date, nearly 100 different types of HPV have been characterized and there is a large number of other types that have not been sequenced yet. Besides being responsible for benign lesions of the skin and mucous membranes, HPV is also involved in the development of various mucocutaneous tumors: Bowen's disease, non-melanoma skin cancers and genital carcinomas. This review discusses the characteristics of HPV, malignant and benign mucous and skin manifestations caused by HPV, besides the main methods of detection and typing of the virus.