Navegando por Palavras-chave "Willis-Ekbom disease"

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    Prevalence and quality of life and sleep in children and adolescents with restless legs syndrome/Willis-Ekbom disease
    (Elsevier Science Bv, 2017) Sander, Heidi Haueisen; Eckeli, Alan Luiz; Passos, Afonso Diniz Costa; Azevedo, Leila; do Prado, Lucila Bizari Fernandes [UNIFESP]; Fernandes, Regina Maria Franca
    Objective: To estimate the prevalence of restless legs syndrome/Willis-Ekbom disease (RLS/WED) and its impact on sleep and quality of life in children and adolescents. Methods: This was a cross-sectional study conducted in the Municipality of Cassia dos Coqueiros, Brazil. Participants included 383 children and adolescents 5-17 years of age. A comparison group was randomly matched by gender and age with the RLS/WED-affected individuals, pairing one by one. Results: Interviews were conducted for 383 individuals by a neurologist experienced in sleep medicine. RLS/WED was diagnosed using the essential clinical criteria for definitive RLS/WED in children recommended by the International Restless Legs Syndrome Study Group. Sleep and quality of life were evaluated using the Sleep Behavior Questionnaire (SBQ) and the Health-related Quality of Life Questionnaire ePediatric Quality of Life Inventory (PedsQL). Comparisons were established with a group of randomly selected individuals without RLS/WED, matched by age and gender (control group). The prevalence of RLS/WED symptoms that manifested at least twice a week was 1.9%. The average age of children with RLS/WED was higher compared to the general population (11.5 +/- 2.3 vs 9.9 +/- 2.5, p < 0.005). A family history of RLS/WED was detected in 90.9% of the patients. The scores obtained by SBQ were higher (53.9 +/- 9.4 vs 47.6 +/- 10.9, p < 0.047), whereas the scores achieved by PedsQL were lower (69.8 +/- 14.8 vs 81.9 +/- 10.4, p < 0.003) in children with RLS/WED compared to controls. Conclusion: The prevalence of RLS/WED symptoms manifested at least twice in the preceding week was 1.9% in children and adolescents. Worsened sleep and quality of life were observed in the study. (C) 2016 Elsevier B.V. All rights reserved.
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    Restless Legs Syndrome and Pain Disorders: What's in common?
    (Springer, 2014-11-01) Goulart, Leonardo Ierardi; Delgado Rodrigues, Raimundo Nonato; Peres, Mario Fernando Prieto [UNIFESP]; Hosp Israelita Albert Einstein; Universidade de Brasília (UnB); Universidade Federal de São Paulo (UNIFESP)
    Between 10 % and 30 % of the population report chronic pain. More than half of these also have sleep complaints. From considering these data, it can be inferred there is a significant overlapping between these conditions. Restless Legs Syndrome/Willis-Ekbom Disease (RLS/WED) is characterized by complaints of an urge to move frequently associated with dysesthesias. From that perspective, these sensations can also have painful characteristics. By the same token, the presence of comorbid diseases as predicted by a higher prevalence RLS/WED, have many of them with pain as an important complaint. Pain is a multidimensional response involving several levels of expression ranging from somatosensory to emotional. the potential shared mechanisms between RLS/WED and pain may involve sleep deprivation/fragmentation effect, inducing an increase in markers of inflammation and reduction in pain thresholds. These are modulated by several different settings of neurotransmitters with a huge participation of monoaminergic dysfunctional circuits. A thorough comprehension of these mechanisms is of utmost importance for the correct approach and treatment choices.