Navegando por Palavras-chave "acromegalia"

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    Adenomas produtores de GH: Análise de 20 casos
    (Academia Brasileira de Neurologia - ABNEURO, 2002-03-01) Tella Jr, Oswaldo Inácio de [UNIFESP]; Herculano, Marco Antonio; Delcelo, Rosana [UNIFESP]; Aguiar, Paulo Henrique; Universidade Federal de São Paulo (UNIFESP); Faculdade de Medicina de Jundiaí Disciplina de Neurocirurgia; Universidade de São Paulo (USP)
    The growth hormone secreting pituitary adenomas can be mono, bi or pluri-hormonals. The most frequent association of GH is with the sub unit alpha or with the prolactin. This type of adenoma comes with the classic alterations of acromegaly, but when they produce more than one hormone, visual symptoms can be present. The adenoma producing just GH hormone is generally microadenoma and the other two groups tend to be macroadenoma. We analyze 20 cases of these adenomas and we have found quite satisfactory surgical result for the mono-hormonal type group. Radiotherapy should be considered in cases of partial resection.
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    Controle hormonal dos adenomas hipofisários pela cirurgia transesfenoidal: evolução dos resultados nos primeiros cinco anos de experiência
    (Sociedade Brasileira de Endocrinologia e Metabologia, 2011-02-01) Barbosa, Erika Ribeiro [UNIFESP]; Zymberg, Samuel Tau [UNIFESP]; Santos, Rodrigo de Paula [UNIFESP]; Machado, Helio Rubens; Abucham, Julio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    OBJECTIVE: To evaluate the initial results of a surgical team in the hormonal control of secreting pituitary adenomas. MATERIALS AND METHODS: In five years 51 functioning adenomas were operated (31 GH-secreting, 14 ACTH-secreting, 5 PRL-secreting and 1 TSH-secreting). Hormonal control was defined as GH < 2,5 ng/mL, normal free-urinary cortisol, lower prolactin and normal T3 and FT4. RESULTS: Control rates were 36% in acromegaly, and 57% in Cushing's disease. Two prolactinomas normalized prolactin levels. Thyroid hormone levels were normalized in the TSH-secreting adenoma. Control of hypercortisolism was positively correlated with years of experience (p = 0.01). CONCLUSION: Our results, although restricted to the beginning of our experience, lie below the reported range of other surgical series with much longer experience. During these years, there was a significant improvement in initial post surgery urinary cortisol levels in Cushing's disease as a function of surgical experience.