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- ItemSomente MetadadadosDifferences in pain expression between male and female newborn infants(Elsevier B.V., 2000-03-01) Guinsburg, Ruth [UNIFESP]; Peres, C. D.; Almeida, MFB de; Balda, RDX; Berenguel, R. C.; Tonelotto, J.; Kopelman, B. I.; Universidade Federal de São Paulo (UNIFESP)The study of neonatal gender differences in pain expression is important since neonatal pain behavior occurs prior to any learned reaction pattern. the objective of this study was to verify the presence of gender differences in pain expression in preterm and term newborn infants. Sixty-five consecutive neonates (37 female and 28 male infants) with gestational age between 28 and 42 weeks and with 25-120 h of Life were studied. Healthy term neonates required a capillary puncture for PKU screening and clinically stable premature infants needed a capillary puncture for glucose dosage. the Neonatal Facial Coding System (NFCS) and the Neonatal Infant Pain Scale (NIPS) were evaluated at bedside prior to the puncture, when patients were at rest, during foot heating; during capillary puncture; and at 1, 3, and 5 min after heel lancing. Results were analyzed by repeated-measures ANOVA followed by the Multiple Comparison Method of Bonferroni. A significant difference among the mean NFCS scores during the six study periods was noted for the whole group of neonates (P < 0.000001). Also, a significant interaction between the NFCS score profile in female and male neonates at the different study periods was observed (P = 0.025). Regarding NIPS, ANOVA showed only a significant difference among the mean NIPS scores during the six study periods for the whole group of neonates (P < 0.000001). No significant interactions between gestational age and time, nor between gestational age and gender were noted, for both NFCS and NIPS. in conclusion, recently born female neonates of all gestational ages expressed more facial features of pain than male infants, during the capillary puncture and 1 min afterwards. Maybe differences in pain processing and/or pain expression among genders may explain this finding. (C) 2000 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.
- ItemAcesso aberto (Open Access)Freqüência do emprego de analgésicos em unidades de terapia intensiva neonatal universitárias(Sociedade Brasileira de Pediatria, 2005-10-01) Prestes, Ana Claudia Y. [UNIFESP]; Guinsburg, Ruth [UNIFESP]; Balda, Rita de Cássia Xavier [UNIFESP]; Marba, Sergio T. M.; Rugolo, Ligia M. S. S.; Pachi, Paulo R.; Bentlin, Maria Regina; Universidade Federal de São Paulo (UNIFESP); Universidade Estadual de Campinas (UNICAMP); Universidade Estadual Paulista (UNESP); Santa Casa de São Paulo Faculdade de Ciências Médicas Departamento de PediatriaOBJECTIVE: To evaluate the use of drugs to relieve the pain of invasive procedures newborn infants cared for at a university hospital NICU. METHODS: A prospective cohort study of all newborn infants hospitalized in four NICU during October 2001. The following data were collected: demographic data of the hospitalized newborn infants; clinical morbidity; number of potentially painful procedures and frequency of analgesic administration. Factors associated with the use of analgesia in this cohort of patients were studied by multiple linear regression using SPSS 8.0. RESULTS: Ninety-one newborn infants were admitted to the NICU during the study period (1,025 patient-days). Only 25% of the 1,025 patient-days received systemic analgesia. No specific drugs were administered to relieve acute pain during any of the following painful events: arterial punctures, venous, capillary and lumbar punctures or intubations. For chest tube insertion, 100% of newborn infants received specific analgesia. For the insertion of central catheters 8% of the newborn infants received painkillers. Only nine of the 17 newborn infants that underwent surgical procedures received any analgesic dosage during the postoperative period. For 93% of patients under analgesia the drug of choice was fentanyl. The presence of mechanical ventilation increased the chance of newborn infants receiving painkillers by 6.9 times and the presence of chest tube increased this chance by five times. CONCLUSION: It is necessary to train health professionals in order to bridge the gap between scientific knowledge regarding newborn infant pain and clinical practice.