Navegando por Palavras-chave "anti-Mullerian hormone"

Agora exibindo 1 - 2 de 2
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Evaluation of the tubular and interstitial functions of the testis in 46,XY patients with ambiguous genitalia
    (Freund Publishing House Ltd, 2000-06-01) Stuchi-Perez, E. Gabas; Lukas-Croisier, C.; De Castro, M.; Baptista, MT Matias; Scolfaro, M. Ribeiro; Marques-De-Faria, A. P.; Hackel, C.; Maciel-Guerra, A. T.; Guerra, G.; Universidade Estadual de Campinas (UNICAMP); Ecole Normale Super; Universidade Federal de São Paulo (UNIFESP)
    Investigation of the origin of sexual ambiguity is complex. Although testicular function has traditionally been assessed only by examining the steroidogenic capacity of Leydig cells and spermatogenesis, it has recently been shown that the measurement of serum anti-Mullerian hormone (AMH) as a marker of Sertoli cell function may also help clinicians. The aim of this study was to evaluate both Leydig and Sertoli cell functions in 46,XY patients with intersex states in order to establish biochemical patterns that would help to reach an etiologic diagnosis. We measured serum androgens, AMH and gonadotropins in 24 patients with sexual ambiguity and XY karyotype: 8 with gonadal dysgenesis (GD), 3 with 3 beta-hydroxy-steroid dehydrogenase deficiency (3 beta HSD), 5 with androgen insensitivity syndrome (AIS), 4 with 5 alpha-reductase 2 (SRD5A2) deficiency, and 4 were of unknown origin or idiopathic, Our results showed that while testosterone was low and gonadotropins elevated in patients with either GD or 3 beta HSD, AMH was low in the former and high in the latter. Serum AMH and gonadotropins were normal or high in patients with 3 beta HSD or AIS, but these could be distinguished by testosterone levels. Serum testosterone and gonadotropins were normal or high in AIS and SRD5A2 deficiency patients; however, while AMH was elevated in AIS, it was not the case in SRD5A2 deficiency patients, indicating that testosterone is sufficient to inhibit AMH within the testis. In idiopathic cases gonadotropins and testosterone were normal, and AMH was normal or low. We conclude that the combined measurement of androgens, AMH and gonadotropins helps to establish the diagnosis in intersex patients.
  • Imagem de Miniatura
    Item
    Acesso aberto (Open Access)
    The predictive value of serum concentrations of anti-Mullerian hormone for oocyte quality, fertilization, and implantation
    (Soc Brasileira Reproducao Assistida-Sbra, 2017) Borges, Edson; Braga, Daniela P. A. F. [UNIFESP]; Setti, Amanda; Figueira, Rita de Cassia; Iaconelli, Assumpto, Jr.
    Objective: This study aimed to identify a possible correlation between serum levels of anti-.Mullerian hormone (AMH) and oocyte quality, embryo developmental competence, and implantation potential. Methods: 4488 oocytes obtained from 408 patients undergoing ICSI cycles were evaluated. Oocyte dimorphisms, embryo quality on days two and three, blastocyst formation competence, fertilization rates, implantation rates, and pregnancy rates were correlated with serum levels of AMH using Pearson's correlation coefficient and regression analysis. Results: A positive correlation was observed between serum levels of AMH and number of retrieved oocytes (CC: 0.600, p<0.001), fertilization rate (CC: 0.595, p=0.048), and number of obtained embryos (CC: 0.495, p<0.001). AMH did not affect the quality of cleavage stage embryos or the chance of blastocyst formation. However, AMH levels affected oocyte quality (OR: 0.75, CI 0.44-.0.96, p<0.001), and implantation (CC: 0,116, p=0.031) and pregnancy (OR: 1.22, CI: 1.03-.1.53, p<0.001) rates. Conclusion: Serum levels of AMH are a useful predictor of ovarian response to COS, oocyte quality, and fertilization. However, AMH levels may also compromise clinical outcomes