Navegando por Palavras-chave "ataxia cerebelar"

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    Neurological manifestations of celiac disease
    (Academia Brasileira de Neurologia - ABNEURO, 2004-12-01) Siqueira Neto, José Ibiapina; Costa, Ana Carolina Leite Vieira; Magalhães, Francisco George; Silva, Gisele Sampaio [UNIFESP]; Federal University of Ceará Department of Internal Medicine; Federal University of Ceará Hospital Universitário Walter; Universidade Federal de São Paulo (UNIFESP)
    Celiac disease (CD/ Nontropicalsprue, gluten-sensitive enteropathy) is a malabsortive condition in which an allergic reaction to the cereal grain-protein gluten (present in wheat, rye and barley) causes small intestine mucosal injury. The onset is in the first four decades of life, with a female to male ratio of 2:1. It may be associated with a wide spectrum of neurological manifestations including cerebellar ataxia, epileptic seizures, dementia, neuropathy, myopathy and multifocal leucoencephalopathy. We report three patients with neurological manifestations related with CD: one with cerebellar ataxia, one with epilepsy and one with cognitive impairment. The diagnosis of CD was confirmed by serologic tests (antiendomysial and antigliadin antibodies) and biopsy of the small intestine. In two patients the neurological symptoms preceded the gastrointestinal abnormalities and in all of them gluten restriction failed to improve the neurological disability. Conclusion: CD should be ruled out in the differential diagnosis of neurological dysfunction of unknown cause, including ataxia, epilepsy and dementia. A gluten free diet, the mainstay of treatment, failed to improve the neurological disability.
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    Translation and validation into Brazilian version of the Scale of the Assessment and Rating of Ataxia (SARA)
    (Academia Brasileira de Neurologia - ABNEURO, 2010-04-01) Braga-neto, Pedro [UNIFESP]; Godeiro-junior, Clecio [UNIFESP]; Dutra, Lívia Almeida [UNIFESP]; Pedroso, José Luiz [UNIFESP]; Barsottini, Orlando Graziani Povoas [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The hereditary ataxias comprise a very large spectrum of genetically determined neurodegenerative disorders with progressive ataxia as the prominent symptom. In order to measure the severity of cerebellar ataxia in an easier and more practical way, it was proposed a new scale: the Scale for the Assessment and Rating of Ataxia (SARA). The objective of this study was to translate and validate SARA into Brazilian Portuguese. METHOD: The SARA was translated into Brazilian Portuguese, analyzed, back translated to English, and compared to the original version. It was applied to 30 patients. In addition to SARA, we applied the International Cooperative Ataxia Rating Scale (ICARS) in all subjects. RESULTS: SARA scale was translated into Brazilian version with adequate internal consistence, but a significant correlation between ICARS and SARA was not found. CONCLUSION: SARA was translated and validated into Brazilian Portuguese language, showing good reliability and validity.