Navegando por Palavras-chave "basal cell carcinoma"

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    Angiogenesis and skin carcinomas with skull base invasion: A case-control study
    (Wiley-Blackwell, 2004-05-01) Cernea, C. R.; Ferraz, A. R.; Castro, IV de; Sotto, M. N.; Logullo, A. F.; Bacchi, C. E.; Potenza, A. S.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Background. Some skin carcinomas may be very aggressive. Intensity of angiogenesis, measured by intratumoral vessel density using expression of CD34, has been associated with tumor aggressiveness. in this study, the expression of CD34 in basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) with skull base invasion was compared with that in tumors with good outcome.Methods. Expression of CD34 was graded as mild, moderate, and intense, in 24 BCCs and 11 SCCs with skull base invasion. the control group included 23 BCCs and 10 SCCs.Results. Intense expression of CD34 was noted in 25.00% of BCCs with skull base invasion, compared with 4.35% in the control group (p =.058). Regarding SCCs, intense expression of CD34 was found in 54.55% of aggressive tumors, compared with 10.00% in the control group (p = 133).Conclusions. A trend toward denser microvascular angiogenesis was observed in both BCCs and SCCs with skull base invasion compared with less aggressive controls. (C) 2004 Wiley Periodicals, Inc.
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    Basal cell carcinoma of the eyelid in children: a report of three cases
    (Nature Publishing Group, 2005-12-01) Al-Buloushi, A.; Filho, JPS; Cassie, A.; Arthurs, B.; Burnier, M. N.; McGill Univ; Royal Victoria Hosp; Universidade Federal de São Paulo (UNIFESP)
    Basal cell carcinoma is the most common eyelid malignancy, accounting for approximately 90% of malignant eyelid tumours. Despite its prevalence in adults, it is extremely rare in children, and usually occurs in the setting of a known genetic defect or following radiotherapy treatment. We report three cases of de novo basal cell carcinoma in children. These children had no known genetic syndromes and had not undergone radiotherapy.
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    Double-bladed scalpel: A new option for harvesting margins in head and neck cancers
    (Karger, 2006-01-01) Cernea, C. R.; Velasco, O.; Gomes, MQT; Vellutini, E.; Hojaij, F. C.; Carlucci, D. de; Nishio, S.; Morais-Besteiro, J.; Ishida, L. C.; Ferraz, A. R.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    Background: in advanced head and neck tumors margins are very rarely comprehensively checked by frozen sections. the goal of this study was to analyze a new proposal for harvesting margins using a double- bladed scalpel. Methods: Thirty-eight patients underwent a comprehensive resection of advanced head and neck tumors with a double- bladed scalpel. Margins were mapped and checked by frozen sections, while tumor resection continued. When positive margins were identified, they were excised again, and checked by frozen sections. Results: Thirty-three patients (87%) had clear skin and soft tissue margins at frozen sections. Five patients (13%) had focal skin and soft tissue-positive margins at frozen sections, which were re-excised. Two patients (5%) had skin and soft tissue-positive margins only at permanent sections. One was reoperated and 1 received radiation therapy. the 3-year local control rate was 58%. Conclusions: in this preliminary study, the double- bladed scalpel appeared to be an interesting option for complete intraoperative evaluation of surgical margins of advanced head and neck tumors. Copyright (c) 2006 S. Karger AG, Basel.
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    Gorlin-Goltz Syndrome and Neoplasms: A Case Study
    (Journal Pedodontics Inc, 2010-12-01) Lopes, Nilza Nelly Fontana [UNIFESP]; Caran, Eliana Maria Monteiro [UNIFESP]; Lee, Maria Lúcia de Martino [UNIFESP]; Silva, Nasjla Saba da [UNIFESP]; Rocha, Andre Caroli; Macedo, Carla R. D. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    Gorlin syndrome is a rare autosomal dominant disorder exhibiting high penetrance and variable expressivity. It is characterized by facial dysmorphism, skeletal anomalies, multiple basal cell carcinomas, odontogenic keratocysts (OKC), palmar and plantar pits, bifid ribs, vertebral anomalies and a variety of other malformations. Various neoplasms', such as medulloblastomas, meningiomas, ovarian and cardiac fibromas are also found in this syndrome. Objective: To describe a twelve-year-old patient with Gorlin-Goltz syndrome, with basal cell carcinomas and promyelocytic leukemia developed after receiving craniospinal radiation for a medulloblastoma. Mild ribs as well as mandibular and maxillar OKC were also diagnosed. Conclusion: The patient with Gorlin-Goltz syndrome should receive close follow-up for early detection of malformations and malignant neoplasias.
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    Shiny White Streaks: A Sign of Malignancy at Dermoscopy of Pigmented Skin Lesions
    (Acta Dermato-venereologica, 2014-01-01) Shitara, Danielle [UNIFESP]; Ishioka, Priscila [UNIFESP]; Alonso-Pinedo, Yarel; Palacios-Bejarano, Leyla; Carrera, Cristina; Malvehy, Josep; Puig, Susana; Hosp Clin Barcelona; Universidade Federal de São Paulo (UNIFESP); Inst Dermatol Jalisco Dr Jose Barba Rubio; Inst Salud Carlos III
    The aim of this study was to evaluate the practical importance of the presence of shiny white streaks (SWS) (chrysalis or crystalline structures in polarized dermoscopy) for suspicion of malignancy, diagnosis of melanoma, and pre-operative estimation of Breslow thickness and its correlation with total dermoscopy score (TDS). SWS were present in 13.6% of 800 consecutive excised lesions. the presence of SWS was associated with malignancy (odds ratio (OR) 10.534, 95% confidence interval (95% Cl) 6.357-17.455, p<0.0005), in the context of melanocytic lesions with invasive melanoma (OR 10.333, 95% CI 3.812-28.014) and melanomas with high TDS (OR 6.286, 95% CI 1.673-23.619), but was also a factor in the diagnosis of featureless and some thin melanomas. These results corroborate the clinical applicability of SWS in aiding the diagnosis of malignancy and helping to raise the general dermatologist's awareness in cases of doubt and featureless lesions.