Navegando por Palavras-chave "botulinum toxin"
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- ItemSomente MetadadadosBilateral hemifacial spasm: A series of 10 patients with literature review(Elsevier B.V., 2008-01-01) Felicio, Andre Carvalho [UNIFESP]; Godeiro-Junior, Clecio de Oliveira [UNIFESP]; Borges, Vanderci [UNIFESP]; Silva, Sonia Maria de Azevedo [UNIFESP]; Ferraz, Henrique Ballalai [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Bilateral hemifacial spasm (HFS) is a rare movement disorder posing diagnostic doubt with other facial dyskinesias. in this report, we describe clinical, radiological and therapeutic features of 10 patients with bilateral HFS. the prevalence of bilateral HFS in our sample was of 2.6%. Clinical characteristics of our patients did not differ from the classic features of unilateral cases. the mean latency for contralateral facial nerve involvement was of 33.3 months. in only one case a vascular abnormality was seen. We conclude that bilateral HFS is rare and that clinical differentiation with other facial dyskinesias should be promptly made to introduce appropriate therapy. (C) 2007 Elsevier B.V. All rights reserved.
- ItemSomente MetadadadosDifferent approaches to dental management of self-inflicted oral trauma: Oral shield, botulinum toxin type A neuromuscular block, and oral surgery(Quintessence Publishing Co Inc, 2008-02-01) Santos, Maria Teresa Botti Rodrigues; Manzano, Felipe Scalco [UNIFESP]; Genovese, Walter Joao; Univ Cruzeiro Sul; Universidade Federal de São Paulo (UNIFESP)Objective: To assess different approaches to the dental management of lip injuries caused by self-inflicted oral trauma in 7 patients. Method and Materials: The patients were grouped based on 3 treatment approaches: group 1, placement of an oral appliance; group 2, botulinum toxin type A neuromuscular block; and group 3, oral surgery. Results and Conclusion: Neuromuscular block can be the first choice of treatment for patients with self-injurious behavior since botulinum toxin A injection is a well-tolerated, safe, and effective procedure, permitting improvement in muscle spasticity, bruxism, range of mouth opening, oral hygiene, and lip trauma. The second option would be the use of the oral appliance, and the last choice is oral surgery. Laser therapy was also found to be effective when applied to traumatic injuries in patients who present self-inflicted oral trauma.
- ItemAcesso aberto (Open Access)Treatment of Non-neurogenic Overactive Bladder with OnabotulinumtoxinA: Systematic Review and Meta-analysis of Prospective, Randomized, Placebo-controlled Clinical Trials(Federacao Brasileira Soc Ginecologia & Obstetricia-Febrasgo, 2018) Arruda, Raquel Martins [UNIFESP]; Takano, Claudia Cristina [UNIFESP]; Girão, Manoel João Batista Castello [UNIFESP]; Haddad, Jorge Milhem; Aleixo, Gabriel Francisco; Castro, Rodrigo Aquino [UNIFESP]We performed a systematic review and meta-analysis of randomized placebo-controlled trials that studied non-neurogenic overactive bladder patients who were treated with 100 units of onabotulinumtoxinA or placebo. The primary purpose of our study was to evaluate the clinical effectiveness with regard to urinary urgency, urinary frequency, nocturia, and incontinence episodes. Our secondary purpose consisted of evaluating the adverse effects. Our initial search yielded 532 entries. Of these, seven studies met all the inclusion criteria (prospective, randomized, placebo-controlled studies, >= 3 points on the Jadad scale) and were selected for analysis. For all primary endpoints, the toxin was more effective than placebo (p < 0.0001
- ItemAcesso aberto (Open Access)The Use of Botulinum Toxin to Treat Infantile Esotropia: A Systematic Review With Meta-Analysis(Assoc Research Vision Ophthalmology Inc, 2017) Issaho, Dayane Cristine [UNIFESP]; de Souza Carvalho, Fabio Ramos [UNIFESP]; Uyeno Tabuse, Marcia Keiko [UNIFESP]; Carrijo-Carvalho, Linda Christian [UNIFESP]; de Freitas, Denise [UNIFESP]PURPOSE. The purpose of this review was to examine the efficacy of botulinum toxin in the treatment of infantile esotropia and to evaluate the average response of BT and its complication rates. METHODS. A research was performed in the Latin American and Caribbean Literature on Health Sciences (LILACS), MEDLINE, and Cochrane Central Register of Controlled Trial (CENTRAL). The database was searched between December 28, 2016 and January 30, 2017. The selection was restricted to articles published in English, Spanish, or Portuguese. There were no date restrictions in the search. RESUITS. Nine studies were eligible for inclusion. The grouped success rate of BT treatment in infantile esotropia was 76% (95% confidence interval [CI]: 61%-89%). For the success rate, 1 2 of 94.25% was observed, indicating a high heterogeneity (P < 0.001). The complication rates were also analyzed. The grouped consecutive exotropia (X'F) rate was 1% (95% CI: 0%-2%). The grouped ptosis rate was 27% (95% CI: 21%-33%). The grouped vertical deviation rate was 12% (95% CI: 4%-22%). The mean change of the deviation after BT injection was -30.7 (95% CI: -37.7, -23.8), demonstrating a significant improvement in alignment. CONCLUSIONS. Botulinum toxin injection into medial recti muscles reveals to be a safe procedure and a valuable alternative to strabismus surgery in congenital esotropia, especially in moderate deviations.
- ItemSomente MetadadadosYoung onset hemifacial spasm in patients with Chiari type I malformation(Elsevier B.V., 2008-01-01) Felicio, Andre Carvalho [UNIFESP]; Godeiro, Clecio de [UNIFESP]; Borges, Vanderci [UNIFESP]; Azevedo Silva, Sonia Maria de [UNIFESP]; Ferraz, Henrique Ballalai [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Hemifacial spasm (HFS) resulting from Chiari type I malformation (CIM) is rare. We retrospectively evaluated five patients with CIM and HFS among a series of 103 subjects. the frequency of HFS associated to CIM was of 4.85%. the clinical profile did not differ from the classical primary cases except for young-onset development of facial spasms in patients with CIM. Three patients were treated with BTX-A injections with favorable outcome. Although rare HFS may be associated with CIM especially in young subjects with peculiar phenotypic characteristics (short neck). Moreover, BTX may be an alternative to posterior fossa decompression in selected cases. (C) 2007 Elsevier B.V. All rights reserved.