Navegando por Palavras-chave "brain neoplasms"

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    Adiposity in childhood cancer survivors: insights into obesity physiopathology
    (Sociedade Brasileira de Endocrinologia e Metabologia, 2009-03-01) Siviero-Miachon, Adriana Aparecida [UNIFESP]; Spinola-Castro, Angela Maria [UNIFESP]; Guerra-Junior, Gil; Universidade Federal de São Paulo (UNIFESP); Universidade Estadual de Campinas (UNICAMP)
    As childhood cancer treatment has become more effective, survival rates have improved, and a number of complications have been described while many of these patients reach adulthood. Obesity is a well-recognized late effect, and its metabolic effects may lead to cardiovascular disease. Currently, studies concerning overweight have focused on acute lymphocytic leukemia and brain tumors, since they are at risk for hypothalamic-pituitary axis damage secondary to cancer therapies (cranial irradiation, chemotherapy, and brain surgery) or to primary tumor location. Obesity and cancer have metabolic syndrome features in common. Thus, it remains controversial if overweight is a cause or consequence of cancer, and to date additional mechanisms involving adipose tissue and hypothalamic derangements have been considered, comprising premature adiposity rebound, hyperinsulinemia, leptin regulation, and the role of peroxisome proliferator-activated receptor γ. Overall, further research is still necessary to better understand the relationship between adipogenesis and hypothalamic control deregulation following cancer therapy.
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    Constipação intestinal em pacientes com tumores intracranianos
    (Escola de Enfermagem de Ribeirão Preto / Universidade de São Paulo, 2006-06-01) Torres, Analuiza Cândido [UNIFESP]; Diccini, Solange [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The effort that occurs during the Valsalva maneuver provokes a raise in intracranial pressure and may decompensate patients with increased intracranial pressure. The aims of this study were to evaluate the incidence of intestinal constipation in the preoperative period of patients with intracranial tumors and establish a relationship between constipation and intracranial pressure decompensation. This study was performed at the neurosurgery unit of Hospital São Paulo, from August to October 2003, evaluating 37 patients. Preoperative time varied from 2 to 34 days (mean 12 days). During this period, 6 (16.2%) patients underwent constipation; all of them received dietary fiber and lactulose, 2 (33.3%) needed enema administration. All patients performed the Valsalva maneuver during defecation and none of them developed intracranial hypertension decompensation.