Navegando por Palavras-chave "central motor conduction time"

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    Relação entre tempo de condução motora central e tempo de condução sensitiva central na avaliação do neurônio motor superior
    (Universidade Federal de São Paulo (UNIFESP), 2015-01-28) Kawagoe, Kleber Edson [UNIFESP]; Manzano, Gilberto Mastrocola Manzano [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: To reduce the time to diagnosis and to find a biomarker are current concerns in Amyotrophic Lateral Sclerosis (ALS) having as main purposes possible early treatments and evaluation of their efficacy. However, there is a paucity of tests reliable for this purpose, mainly for the neurophysiological study of upper motor neuron (UMN). Objective: to evaluate the ratio between the Central Motor Conduction Time (CMCT) and Central Sensory Conduction Time (CSCT) in Motor Neuron Diseases (MND). Methods: CMCT and CSCT (peak ? pCSCT and onset - oCSCT) were measured from the median and ulnar nerves bilaterally, in 21 healthy volunteers (controls) and in 18 patients with acquired MND, and the ratio (CMCT/CSCT) was calculated. UMN involvement was evaluated according to deep tendon reflexes and MND clinical type. Results: only CMCT/oCSCT ratio (oR) showed significant difference in both median nerves, when comparing controls and patients with brisk reflexes ? right median nerve (p = 0.0053) and left median nerve (p = 0.0083). Conclusions: The ratio CMCT/CSCT between onset was able to detect involvement in different types of MND. New studies with this ratio should be evaluated in relation to ALS progression in UMN.