Navegando por Palavras-chave "chemotherapy and thromboembolism"

Agora exibindo 1 - 1 de 1
  • Nenhuma Miniatura disponível
    Item
    Somente Metadadados
    Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients
    (Wiley-Blackwell, 2014-03-01) Yamashita, Eliana K.; Teixeira, Bianca M.; Yoshihara, Renata N.; Kuniyoshi, Renata K.; Alves, Beatriz C. A.; Gehrke, Flavia S.; Vilas-Boas, Viviane A.; Correia, Joao A.; Azzalis, Ligia A. [UNIFESP]; Junqueira, Virginia B. C. [UNIFESP]; Pereira, Edimar Cristiano [UNIFESP]; Fonseca, Fernando L. A. [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    BackgroundHyperhomocysteinemia in breast cancer (BC) patients can be a risk factor for thromboembolic events. This study aimed to evaluate homocysteine and its cofators (folic acid and vitamin B12) concentrations and platelet count at diagnosis of BC, 3 and 6 months after the beginning of chemotherapy treatment and to correlate them with clinical data.MethodsThirty-five BC patients were included; blood samples were obtained by venipuncture. Plasmatic Hcy and cofactors concentrations were measured by competitive chemiluminescent enzyme immunoassay method. Platelet count was done using an automated analyzer. Statistical analysis was performed using the software SPSS.ResultsDuring chemotherapy, homocysteine (P = 0.032) and vitamin B12 (P < 0.001) concentrations increased, while folate and platelets decreased (P < 0.001). Among the clinical data, the menopausal status showed significant positive correlation (P = 0.022) with homocysteine concentration increase.ConclusionsEvaluation of homocysteine concentrations during chemotherapy is extremely important because their levels increase during chemotherapy treatment, thus increasing the risk of thromboembolism development.