Navegando por Palavras-chave "chronic stress"

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    Chronic stress may modulate periodontal disease: A study in rats
    (Amer Acad Periodontology, 2008-04-01) Peruzzo, Daiane C.; Benatti, Bruno B.; Antunes, Isabela B. [UNIFESP]; Andersen, Monica L. [UNIFESP]; Sallum, Enilson A.; Casati, Marcio Z.; Nociti, Francisco H.; Nogueira-Filho, Getulio R.; Universidade Estadual de Campinas (UNICAMP); Universidade Federal de São Paulo (UNIFESP); Bahia Sci Fdn
    Background: the present study aimed to evaluate whether chronic stress (CS) affects ligature-induced periodontal disease and to investigate the impact of CS on the mRNA levels of interleukin (IL)-1 beta, -1 receptor antagonist, -6, and -10, interferon-gamma (IFN-gamma), receptor activator of nuclear factor-kappa B ligand (RANKL), and osteoprotegerin in the gingival tissues of rats.Methods: Sixty male Wistar rats were assigned randomly to three groups: G1 (control; non-ligated sites), G2 (periodontal disease), and G3 (periodontal disease associated with restraint stress for 12 hours/day for the entire study). After 30 days, all animals were sacrificed by decapitation. Blood samples were taken, and the concentrations of corticosterone and catecholamines were measured as biomarkers of CS. Marginal tissues around ligated and non-ligated teeth were harvested, and gene expression was assessed by quantitative polymerase chain reaction. Moreover, the area of bone loss (ABL) was determined histometrically.Results: Data analysis showed that CS increased serum levels of stress biomarkers (P <0.05), ligature placement resulted in a significant ABL compared to non-ligated sites, CS significantly increased the amount of ABL in inflamed sites (P <0.001), and CS significantly increased mRNA levels of proinflammatory (ILAP and -6 and IFN-gamma) and anti-inflammatory (IL-10) cytokines and proresorptive factor (RANKL) in ligated sites (P<0.05).Conclusion: CS significantly increased bone loss resulting from ligature-induced periodontitis by a local increase in proinflammatory and proresorptive factors.
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    Efeitos das experiências adversas precoces e tardias no comportamento alimentar e morfologia da glândula adrenal, fígado e baço de ratos sprague-dawley submetidos ao estresse na vida adulta
    (Universidade Federal de São Paulo (UNIFESP), 2016-11-29) Pastene, Belgica Katuscha Vasquez [UNIFESP]; Smith, Ricardo Luiz Smith [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Early interruption of maternal bonding and social isolation are variables involved in social and emotional behavior, which can cause increased anxiety, especially in stressful situations. However, there is no research to explain the phenomenon of overeating anxiety disorder associated with these factors in an animal model and their effects on the morphology of the adrenal gland (AG), liver and spleen. Henceforth, the objective of this research was to determine the effects of early and late intake behavior in adrenal gland, liver and spleen morphology of Sprague-Dawley rats subjected to chronic stress during adulthood. We used 35 newborn female rats, maintained under standardized suckling and feeding conditions. The rats were randomized into 2 control groups (C1 and C2) and 3 experimental groups exposed to an early adverse experience (E1), late (E2) and early-late (E3) subsequently subjected to chronic intermittent stress in adulthood (C2, E1, E2 and E3). Intake behavior of groups and morphological changes of the left AG, the liver and spleen were evaluated by determining morphometric and stereological parameters for each organ. The early and late adverse experiences are factors that influence coping with a stressful situation favoring increased caloric intake and palatable food choice. The morphological features of the AG, the liver and spleen of rats can be affected by exposure to chronic stress, however, when individuals have undergone previous adverse experiences, these changes are more obvious.
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    Stress-induced endocrine response and anxiety: the effects of comfort food in rats
    (Informa Healthcare, 2014-05-01) Ortolani, Daniela [UNIFESP]; Garcia, Marcia Carvalho [UNIFESP]; Melo-Thomas, Liana [UNIFESP]; Spadari-Bratfisch, Regina Celia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The long-term effects of comfort food in an anxiogenic model of stress have yet to be analyzed. Here, we evaluated behavioral, endocrine and metabolic parameters in rats submitted or not to chronic unpredictable mild stress (CUMS), with access to commercial chow alone or to commercial chow and comfort food. Stress did not alter the preference for comfort food but decreased food intake. in the elevated plus-maze (EPM) test, stressed rats were less likely to enter/remain in the open arms, as well as being more likely to enter/remain in the closed arms, than were control rats, both conditions being more pronounced in the rats given access to comfort food. in the open field test, stress decreased the time spent in the centre, independent of diet; neither stress nor diet affected the number of crossing, rearing or grooming episodes. the stress-induced increase in serum corticosterone was attenuated in rats given access to comfort food. Serum concentration of triglycerides were unaffected by stress or diet, although access to comfort food increased total cholesterol and glucose. It is concluded that CUMS has an anorexigenic effect. Chronic stress and comfort food ingestion induced an anxiogenic profile although comfort food attenuated the endocrine stress response. the present data indicate that the combination of stress and access to comfort food, common aspects of modern life, may constitute a link among stress, feeding behavior and anxiety.