Navegando por Palavras-chave "controle clínico"

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    Influência do polimorfismo -174 g/c do gene promotor da interleucina-6 no controle clinico da polipose nasossinusal
    (Universidade Federal de São Paulo (UNIFESP), 2014-11-28) Hirai, Elcio Roldan [UNIFESP]; Kosugi, Eduardo Macoto Kosugi [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Introduction: Nasal polyposis (NP) is a chronic inflammatory disease, which depends on several inflammatory mediators, especially, the interleukin-6 (IL-6). IL-6 -174 G/C promoter gene polymorphism can determine different cytokine profiles regulations which could influence the clinical spectrum from this disease. Aim: To evaluate the influence of IL-6 -174 G/C promoter gene polymorphism on current clinical control of NP. Methods: Cross-sectional study with 47 NP patients with IL-6 genotyping. Clinical control of disease parameters were assessed, like symptoms, oral medication use, SNOT-22 scores, endoscopic status and clinical control of disease status. Results: GG genotype had 30 individuals; GC genotype, 17. Both groups presented similar distribution of age, gender, previous surgery, and comorbidities. Clinical control of disease parameters were not different between groups. Conclusion: IL-6 -174 G/C promoter gene polymorphism did not seemed to lead to a worse clinical control of nasal polyposis.