Navegando por Palavras-chave "corneal"

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    Efeito do mel e do soro autólogo na cicatrização do epitélio corneano em coelhos
    (Conselho Brasileiro de Oftalmologia, 2005-06-01) Malavazzi, Gustavo Ricci [UNIFESP]; Lake, Jonathan Clive; Dantas, Paulo Elias Correa; Universidade Federal de São Paulo (UNIFESP); Irmandade da Santa Casa de Misericórdia de São Paulo Departamento de Oftalmologia Seção de Córnea e Doenças Externas
    PURPOSE: To evaluate the efficacy of pure honey and 20% autologous serum and BSS® in corneal epithelial healing in rabbits after 48 hours. METHODS: All solutions were applied after an epithelial removal of 13-millimeters diameter area. Areas of epithelial healing were studied at 12, 24 and 48 hours. The eyes were treated every four hours during 2 days. All treated eyes were assigned to a control group (contralateral eye) treated with a balanced saline solution. RESULTS: All studied groups were not significantly differents. In group one, the eyes treated with honey and the control were similar (p<0.87). In the second group the eyes treated with autologos serum and the control presented no difference in the mean score (p<0.072). CONCLUSION: Corneal epithelial healing in rabbits did not show improvement after application of either honey or autologous serum. It was possible to stabilish that the autologous serum treated eyes were clinicaly better than the control group but without statistical significance.
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    Enxerto das células-tronco imaturas da polpa dentária humana para tratamento da deficiência de células-tronco límbicas
    (Universidade Federal de São Paulo (UNIFESP), 2015-11-26) Monteiro, Babyla Geraldes [UNIFESP]; Kerkis, Irina Kerkis [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    The limbal stem cells are responsible for maintaining the integrity of the corneal epithelium. In his absence the peripheral conjunctival epithelium invades the surface of the cornea, resulting in opacification and severe visual impairment, called features deficiency limbic stem cells. The study isolated and characterized immature stem cells from dental pulp presenting mesenchymal and molecular markers of embryonic stem cells. The objectives were to differentiate these in vitro and in vivo cell and evaluation of their potential graft in the limbic region. The results showed that they were capable of differentiating restoring the transparency of the corneal epithelium.
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    Histopathological diagnosis of corneal button specimens: An epidemiological study
    (Taylor & Francis Inc, 2007-01-01) Godeiro, Katyanne D. [UNIFESP]; Coutinho, Anamaria B. [UNIFESP]; Pereira, Patricia da Rocha [UNIFESP]; Fernandes, Bruno F. [UNIFESP]; Cassie, Amanda; Burnier, Miguel Noel Nascente [UNIFESP]; Henry C Witelson Ocular Pathol Lab; McGill Univ; Universidade Federal de São Paulo (UNIFESP)
    Purpose: To determine the most common histopathological diagnosis of corneal specimens from penetrating keratoplasty (PKP). Methods: the records of 500 corneal specimens submitted to biopsy at the Henry Witelson Ocular Pathology Laboratory, Montreal, Canada, from 1999 to 2004 were reviewed. Age, sex, clinical indications, and histopathological findings were analyzed. Results: Chronic keratitis (45.6%) was the most common pathological diagnosis, followed by corneal edema (25.8%), dystrophy (12.8%), keratoconus (KC) (9.2%), acute keratitis (5.6%), and degeneration (1.0%). Among the specimens with chronic keratitis, regraft was the most common clinical indication (39.0%). in the group of acute keratitis, ulcerative condition was the leading cause (75,0%). Fuchs' endothelial dystrophy represented 79.7% of the clinical diagnoses in the group of corneal dystrophies. the median patient age was 70-79 years, and the gender distribution was nearly symmetric. Conclusion: the present study is important for determining the most common histopathological diagnoses of corneal button specimens and the correlation with the age, gender, and clinical indications of PKP.
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    Histopathological Study of Delayed Regraft After Corneal Graft Failure
    (Lippincott Williams & Wilkins, 2011-02-01) Santos, Leonardo N. [UNIFESP]; Moura, Leticia Rielo de [UNIFESP]; Fernandes, Bruno F. [UNIFESP]; Cheema, Devinder P.; Burnier, Miguel N. [UNIFESP]; McGill Univ; Henry C Witelson Ocular Pathol Lab; Universidade Federal de São Paulo (UNIFESP)
    Purpose: To evaluate the histopathological features of corneal graft failures over time.Methods: A single-center retrospective analysis was performed on corneal specimens diagnosed as corneal graft failure retrieved from the Henry C. Witelson Ophthalmic Pathology Laboratory and Registry (Montreal, Canada) over a 9-year period. the corneal buttons were divided into 3 different groups according to the time between the diagnosis of corneal graft failure and regraft. Corneal specimens obtained during keratoplasty were subjected to hematoxylin and eosin and periodic acid-Schiff. Five different histopathological findings were evaluated in each specimen.Results: Overall, the most common histopathological finding was endothelial decompensation (97.2%). Subepithelial pannus (38.9%), vessels in the corneal stroma (11.1%), and anterior synechiae (2.8%) were the other present findings. the inflammatory reaction was considered discrete in 83.3% of the cases. the only significant histopathological finding correlated with time was the presence of vessels in the corneal stroma (P = 0.0092).Conclusions: Corneal neovascularization, represented by the presence of vessels in the corneal stroma, was the only histopathological finding correlated with time. Because it is a known factor of poor prognosis, our findings strongly support that early regraft has higher chances of success.