Navegando por Palavras-chave "coronary artery calcification"

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    The association between coronary artery calcification progression and loss of bone density in non-dialyzed CKD patients
    (Dustri-verlag Dr Karl Feistle, 2012-12-01) Watanabe, Renato [UNIFESP]; Lemos, Marcelo Montebello [UNIFESP]; Carvalho, Aluizio Barbosa de [UNIFESP]; Rochitte, Carlos Eduardo; Santos, Raul D.; Draibe, Sergio A. [UNIFESP]; Canziani, Maria Eugenia [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    Background: Coronary artery calcification (CAC) and low bone density are coexisting deleterious conditions commonly shared by chronic kidney disease (CKD) patients. in the present study, we aimed to investigate whether the progression of CAC was associated with overtime reduction in bone density in non-dialyzed CKD patients. Methods: This is a prospective study of 24 months including 72 non-dialyzed CKD patients Stages 2 - 4 (age 57.6 +/- 10.3 years, 62% male, 22% diabetics). CAC and vertebral bone density (VBD) were measured by computed tomography. Results: At baseline, 46% of the patients had CAC (calcified group) and calcification was not identified in 54% of the patients (non-calcified group). the calcified group was older, predominantly male, and had lower VBD in comparison to non-calcified group. CAC progression was observed only in the calcified group (91% of the patients increased calcium score). the multiple regression analysis revealed loss of VBD as the independent determinant of CAC progression in these patients. Conclusion: CAC progression was associated with loss of VBD in non-dialyzed CKD patients.
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    Increased visceral adiposity is associated with coronary artery calcification in male patients with chronic kidney disease
    (Nature Publishing Group, 2013-06-01) Aoqui, C. [UNIFESP]; Cuppari, L. [UNIFESP]; Kamimura, Maria Ayako [UNIFESP]; Canziani, M. E. F. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    BACKGROUND/OBJECTIVE: Recent epidemiological data have shown that abdominal fat accumulation is associated with increased risk of cardiovascular events in patients with chronic kidney disease (CKD). This study aimed to investigate the association between visceral adiposity and coronary artery calcification (CAC) in CKD patients.SUBJECTS/METHODS: Cross-sectional study with 65 nondialyzed CKD male patients (59 +/- 9 years, CKD stages 3 and 4). Abdominal fat compartments were assessed by computed tomography (CT) at L4-L5 level. Visceral to subcutaneous (V/S) fat ratio was calculated. Visceral obesity was defined as a V/S fat ratio greater than the median value of the sample study (>0.55). CAC was detected by multi-slice CT. CAC scores were calculated with the Agatston method.RESULTS: CAC was present (calcium score > 10 AU) in 66% of patients. in the group with visceral obesity, the CAC score was significantly higher. This group had lower adiponectin and higher leptin levels compared to patients without visceral obesity. in the whole sample, higher V/S fat ratio was associated with CAC score, independently of age, body mass index, diabetes, ionized calcium, smoking or renal function.CONCLUSION: Our results show an association between visceral obesity and CAC in CKD patients, suggesting a deleterious effect of visceral fat in these patients. Increased visceral adiposity might enhance cardiovascular risk in this particular population.
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    Vascular calcification in peritoneal dialysis patients
    (Multimed Inc, 2008-03-01) Ammirati, Adriano Luiz [UNIFESP]; Moyses, Rosa Maria Affonso; Canziani, Maria Eugênia Fernandes [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    Vascular calcification ( VC) is being recognized as a common complication at all stages of chronic kidney disease, particularly in patients on dialysis. Traditional and nontraditional cardiovascular risk factors both appear to be involved in the development of VC in this population. Although few studies focusing exclusively on peritoneal dialysis (PD) patients are available, some data support the view that VC constitutes an independent prognostic marker of morbidity and mortality in the PD population. In this review, we discuss the potential pathophysiologic pathways of VC in PD patients, and we examine the relevant clinical data.