Navegando por Palavras-chave "dipyrone"

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    Adjunct dipyrone in association with oral morphine for cancer-related pain: the sooner the better
    (Springer, 2007-11-01) Souza, Jose F. Duarte; Lajolo, Paula P.; Pinczowski, Helio; del Giglio, Auro; ABC Fdn Sch Med; Universidade Federal de São Paulo (UNIFESP); Albert Einstein Hosp
    Introduction Adjunct nonopioid analgesics may improve pain control in patients with cancer needing morphine or its derivates. Dypirone is a cheap nonopioid analgesic widely used in many countries.Objective the objective of the study was to evaluate, whenever morphine was started, if associating dipyrone with it would improve pain control and if this effect was time dependent.Materials and methods This is a double-blind placebo-controlled randomized crossover study. Thirty-four ambulatory cancer patients experiencing cancer-related pain for which oral morphine was to be started at the dose of 10 mg orally (PO) every 4 h were randomized to take either dipyrone 500 mg PO every 6 h or placebo. After 48 h, patients would be switched from dipyrone to placebo and vice versa. Pain was the primary outcome and was measured using a visual analogue scale before starting medications, at 48 and 96 h.Results We randomized 16 patients to start with placebo (group 1) and 18 with dipyrone (group 2). Pain scores for groups 1 and 2 were at baseline: 7.31 +/- 0.29 vs 6.88 +/- 0.28 (p=0.3), at 48 h: 7.06 +/- 0.32 vs 5.5 +/- 0.31 (p=0.001), and at 96 h: 3.18 +/- 0.39 vs 1.94 +/- 0.37 (p=0.03). Both groups had significant improvements in pain scores after introducing dipyrone (p < 0.001, for both). Main toxicities were nausea, vomiting, epigastric pain, and myalgias. Twenty-eight patients chose dipyrone, four placebo, and two were indifferent.conclusions We conclude that dipyrone adds significantly to the analgesic effect of morphine and, when given at the time of starting morphine, results in better pain scores even after dipyrone is discontinued.
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    Morphological and biochemical action of dipyrone on rat placenta
    (Elsevier B.V., 1996-04-01) Espiridião, Silvia [UNIFESP]; Oliveira, R. M.; Doine, A.; Simoes, M. J.; Focchi, GRA; Neto, J. E.; Kopelman, B. I.; Kulay Júnior, Luiz [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    1. the morphological and biochemical action of dipyrone (N-[2,3-dimethyl-5-oxo-1-phenyl-3-pyrazolin-4-yl] methylamino methanesulfonate, sodium monohydrate) on the placenta of albino rats was studied by means of karyometry of trophoblastic giant cells and by determinations of DNA, RNA and total protein contents.2. the animals were treated with a single daily dose of 50 mg/kg body weight during 5 different periods: from the 9th to the 12th, 11th to the 14th, 13th to the 16th, 15th to the 18th or 17th to the 20th day of pregnancy,3. Karyometric results showed that the nuclear volumes of placental cells in rats treated with dipyrone during the first 3 periods were significantly greater than in control animals and that, closer to term, no differences were observed in this regard. Only the animals treated from the 9th to the 12th day of pregnancy had higher placental contents of DNA, RNA and protein than the corresponding controls.4. Our results showed that dipyrone had a blocking effect on placental cell division which occurs mainly in the initial steps of placental development.