Navegando por Palavras-chave "doença de Chagas"

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    Disfunção endotelial venosa em pacientes com doença de Chagas sem insuficiência cardíaca
    (Sociedade Brasileira de Cardiologia - SBC, 2006-06-01) Plentz, Rodrigo Della Méa [UNIFESP]; Irigoyen, Maria Claudia [UNIFESP]; Muller, Andreia Simone [UNIFESP]; Casarini, Dulce Elena [UNIFESP]; Rubira, Marcelo Custodio; Moreno Junior, Heitor; Mady, Charles; Ianni, Bárbara Maria; Krieger, Eduardo Moacir; Consolim-Colombo, Fernanda; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP); Universidade Estadual de Campinas (UNICAMP); Universidade de Cruz Alta
    OBJECTIVE: To analyze the venous endothelial function in Chagas' disease patients without heart failure. METHODS: The Chagas' disease Group (G1) was composed by 14 women and 2 men aged 46 ± 2,7 and the Control Group (G0) by 7 women and 1 man matched by age, weight and height. Dorsal Hand Vein Compliance Technique was used to evaluate the venous endothelial function. Crescent doses of phenylephrine were infused to get a 70% pre-constriction of the vein; after that, acetylcholine and sodium nitroprusside were respectively administrated to analyze the endothelium-dependent and -independent venodilation. RESULTS: No significant systemic hemodynamic changes were observed in both groups during the experiment. The necessary phenylephrine dose to reach 70% pre-constriction of the vein was significantly higher in the G1 (1116 ± 668,2 ng/ml) compared to G0 (103 ± 28 ng/ml) p = 0,05. The endothelium-dependent venous dilation was significantly lower in G1 (65,5 ± 8%) compared to G0 (137 ± 20 %) p = 0,009. No difference was observed in the endothelium-independent venous dilatation between groups. CONCLUSION: Patients with Chagas' disease without heart failure presented venous endothelial dysfunction.
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    Gravidez, puerpério e doença vascular cerebral
    (Academia Brasileira de Neurologia - ABNEURO, 1996-06-01) Fukujima, Marcia Maiumi [UNIFESP]; Oliveira, Roberto De Magalhães Carneiro de [UNIFESP]; Shimazaki, Jean Carlos [UNIFESP]; Lima, José Geraldo de Camargo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Six patients who presented cerebrovascular disease during puerperium or pregnancy were studied. One of them presented hemorrhagic stroke caused by intracerebral bleeding due to pre-eclampsia. Three patients presented ischemic stroke, they all had positive serologic reactions for Chagas' disease, but only two of them had clinical cardiopathy; one of these patients had anticardiolipin antibody. The other two patients presented cerebral venous thrombosis of sagittal sinus. Both were smokers and one of them used oral contraceptive. We emphasize the importance of clinical investigation to seek for the common causes of cerebrovascular disease in young people, with special attention to Chagas disease in Brazil.
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    Neurologic complications after heart transplantation
    (Academia Brasileira de Neurologia - ABNEURO, 2002-06-01) Malheiros, Suzana Maria Fleury [UNIFESP]; Almeida, Dirceu Rodrigues de [UNIFESP]; Massaro, Ayrton R. [UNIFESP]; Castelo Filho, Adauto [UNIFESP]; Diniz, Rosiane Viana Zuza [UNIFESP]; Branco, João Nelson Rodrigues [UNIFESP]; Carvalho, Antonio Carlos [UNIFESP]; Gabbai, Alberto Alain [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    OBJECTIVE: Neurologic complications are known as important cause of morbidity and mortality in orthotopic heart transplantation. Our aim was to identify the frequency and outcome of neurologic complications after heart transplantation in a prospective observational study. METHOD: From September 93 to September 99, as part of our routine heart transplantation protocol all patients with end-stage cardiac failure were evaluated by the same neurologist before and at the time of any neurologic event (symptom or complaint) after transplantation. RESULTS: Out of 120 candidates evaluated, 62 were successfully transplanted (53 male; median age 45.5 years, median follow-up 26.8 months). Fifteen patients (24%) had ischemic, 22 (35%) idiopathic, 24 (39%) Chagas' disease and 1 (2%) had congenital cardiomyopathy. Neurologic complications occurred in 19 patients (31%): tremor, severe headache, transient encephalopathy and seizures related to drug toxicity or metabolic changes in 13; peripheral neuropathy in 4; and spinal cord compression in two (metastatic prostate cancer and epidural abscess). No symptomatic postoperative stroke was observed. CONCLUSIONS: Although frequent, neurologic complications were seldom related to persistent neurologic disability or death. Most of the complications resulted from immunosuppression, however, CNS infection was rare. The absence of symptomatic stroke in our series may be related to the lower frequency of ischemic cardiomyopathy.
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    Trypanosoma cruzi meningoencephalitis in AIDS mimicking cerebral metastases: case report
    (Academia Brasileira de Neurologia - ABNEURO, 1996-03-01) Pimentel, Pedro Camilo A. [UNIFESP]; Handfas, Benjamin W.; Carmignani, Márcia; Universidade Federal de São Paulo (UNIFESP); Hospital Albert Einstein Division of Neuroimaging
    A case of Chagas' meningoencephalitis in a 47 year-old patient with AIDS is presented. The diagnosis was established by examination of the cerebrospinal fluid which showed the presence of Trypanosoma cruzi. CT-scan revealed multiple cerebral lesions which only became evident by contrast administration. A second CT after 13 days showed a severe evolution with displacement of the midline structures leading to the patient's death. This case, as well as other case reports published, has shown the fulminant evolution of Chagas' meningoencephalitis in AIDS patients and the importance of cerebrospinal fluid examination for the diagnosis.