Navegando por Palavras-chave "electroretinography"

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    ELECTRORETINOGRAPHY AND STANDARDIZED INTERVIEW IN EVALUATING NIGHT BLINDNESS IN CLASS III OBESITY INDIVIDUALS
    (Springer, 2016) Pereira, S. E.; Saboya, C. [UNIFESP]; Rodrigues, B. C.; Goncalves, I. A. A.; Oliveira E Silva, L. G.; Ramalho, A.
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    Eletrorretinograma de campo total utilizando um protótipo de eletrodo monopolar de microfibra condutiva em pacientes com distrofia retiniana
    (Universidade Federal de São Paulo (UNIFESP), 2015-04-30) Pereira, Josenilson Martins [UNIFESP]; Berezovsky, Adriana [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objective: The objective of this study was to evaluate the clinical utility of prototype disposable electrode conductive microfiber UNIFESP as a tool evaluation of retinal function in patients with retinal dystrophy, following the standard protocol of the full-field electroretinography (ERG) of International Society for Clinical Electrophysiology of Vision (ISCEV). Methods: This study was approved by the Ethics in Research Federal University of São Paulo under number 1087/08. They participated this study 54 patients, 28 males and 26 females with mean age was 36.17 ± 16.39 years, 31.76 years and median diagnosis Previous retinal dystrophy. All participants underwent the ERG total field using the reusable bipolar electrode Burian-Allen for diagnostic confirmation and further examination and were later using two disposable monopolar electrode conductive microfiber (DTL® imported and UNIFESP prototype). Electroretinograms for the record, the electrodes were randomly selected in two consecutive visits maximum interval of 7 days. The VERIS 5.1.9 EDI system was used to the acquisition and analysis of data. The results were analyzed ERG Separate the linear regression method, using the software Statistical StataSE 11. The retinal dystrophy type was classified based the clinical criteria such as Stargardt's disease, cone dystrophy, retinitis pigmentosa, cone-rod dystrophy and others. The responses of the ERG They were compared with normative data from our own laboratory. Results: The magnitude and quality of the shapes of the waves Electrical obtained with the two electrodes were similar for all ERG responses. The amplitudes obtained with the prototype UNIFESP They tended to be lower than the answers coming from the DTL® for more amplitudes. The regression equations showed that the times culmination obtained from the UNIFESP prototype tended to be later in relation to DTL® electrode for further completion times. although the above results, there was no statistical difference significant for all the parameters of amplitude and time between the completion of DTL® the electrode and UNIFESP prototype. When the analyzes were diseases was separated by greater variability of responses for breadth parameter as compared to the completion time. At amplitudes of resulting responses DTL® electrode tended to be higher in the following diseases: Stargardt disease, cone dystrophy dystrophy and type cone-rod. The regression equations show that the time culmination obtained from the UNIFESP prototype tended to be more late, but there was no statistically significant difference. Conclusions: The results showed that the waveforms obtained with the two types of electrodes were remarkably similar for all ERG responses. The UNIFESP prototype can be an alternative instrument for the clinical record of ERG in the evaluation of retinal function.
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    Multifocal electroretinography, color discrimination and ocular toxicity in tamoxifen use
    (Taylor & Francis Inc, 2007-04-01) Salomão, Solange Rios [UNIFESP]; Watanabe, Sung Eun Song [UNIFESP]; Berezovsky, Adriana [UNIFESP]; Motono, Marcia; Universidade Federal de São Paulo (UNIFESP); Antonio Prudente Fdn
    Purpose: To study prospectively retinal function, color discrimination, and ocular toxicity in women treated with standard-dosage tamoxifen for breast cancer. Methods: Thirty visually asymptomatic patients with at least 2 years of continuous tamoxifen therapy underwent multifocal electroretinography (ERG), color discrimination testing, and ophthalmic examination. the results were compared with 17 patients who were not taking tamoxifen after breast cancer surgery and to an additional age-matched group of 21 healthy women. Results: Multifocal electroretinogram amplitudes and latencies were comparable among the three studied groups, and individual recordings were within age norms from our own lab. in the treated group, mild diffuse color vision loss was found in two patients with normal fundi. Three other patients had ocular toxic effects, with two cases of refractile retinal crystals and one case of keratopathy. Conclusions: the aspects of central retinal function that are assessed by multifocal ERG were not affected even after at least 2 years of tamoxifen use, suggesting that the multifocal ERG is not sufficiently sensitive to detect tamoxifen-associated change that might occur. Some degree of color vision loss and ocular toxic effects were found in a few cases of this cohort suggesting that women using tamoxifen should receive an eye exam at least as often as recommended for middle-aged people.
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    Standard full-field electroretinography in healthy preterm infants
    (Kluwer Academic Publ, 2003-11-01) Berezovsky, Adriana [UNIFESP]; Moraes, NSB; Nusinowitz, S.; Salomão, Solange Rios [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Jules Stein Eye Inst
    The purpose of this study was to determine electroretinographic parameters according to the standard protocol from the International Society for Clinical Electrophysiology of Vision (ISCEV) in healthy preterm infants with normal fundus. Seventeen healthy preterm infants with normal fundus were recruited and divided in two age groups: 3-week group, nine infants with mean adjusted age at test = 2.67 +/- 0.92 weeks and 8-week group, eight infants with mean adjusted age at test = 7.92 +/- 1.72 weeks. Full-field ERGs were obtained with a Burian-Allen bipolar contact lens electrode from the anesthetized cornea in one eye, through a fully dilated pupil after 30 min of dark adaptation. the standard ISCEV protocol was used and the following responses were recorded: rod, maximal, oscillatory potentials, cone and 30 Hz flicker. Median values and 1st, 5th, 95th and 99th percentiles for amplitude and implicit time are described for both age groups. There was statistically larger amplitude for 30 Hz flicker (t = 2.191; p = 0.046) and for cone response (t = 2.307; p = 0.044) in the 8-week-old group. Statistically shorter implicit times were found in 8-week group for rod response (t = 3.219; p = 0.015), cone response (t = 2.839; p = 0.016) and flicker response (t = 3.326; p = 0.005). Shortening of implicit time was evident in the older group of preterms and this finding is consistent with other maturational studies confirming the anatomical and functional development of the photoreceptors. Medians and ranges between the 1st and 99th and the 5th and 95th percentiles can be used as a baseline for future comparisons with infants with ROP.
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    STRATUSOCT and multifocal ERG in unilateral acute idiopathic maculopathy
    (Springer, ) Aggio, Fabio Bom [UNIFESP]; Farah, M. E.; Meirelles, R. L.; Souza, E. C. de; Aggio, Fabio Bom [UNIFESP]; Farah, M. E.; Meirelles, R. L.; Souza, E. C. de; Universidade Federal de São Paulo (UNIFESP)
    Background: Unilateral acute idiopathic maculopathy (UAIM) is a rare entity, in which an inflammatory process involves the macular retinal pigment epithelium (RPE) and outer retina. It represents a wide spectrum of ocular findings not consistently present in all patients, which may lead to difficulties in the recognition of the condition. Methods: This observational case report presents the third-generation optical coherence tomography (StratusOCT) and multifocal electroretinogram (mfERG) findings in a 31-year-old woman with UAIM in the acute phase as well as two months later, and discusses the role of StratusOCT in the diagnosis. Results: in the acute phase, StratusOCT demonstrated abnormal heterogeneous hyperreflectivity and thickening at the level of the outer retina and RPE in the foveal region. Two months after the initial presentation, StratusOCT examination showed a subfoveal area of homogeneous hyperreflectivity that extended from the RPE to the outer retinal layers with posterior shadowing, and sparse points of hyperreflectivity at several different levels of the neurosensory retina, including its superficial layers. the foveal retinal thickness during the acute phase was thicken compared with that after resolution. Seven days after the initial evaluation, mfERG showed severely reduced N1-P1 amplitudes with normal latencies in the region corresponding to the affected area of the papillomacular bundle and fovea. Two months later, mfERG results were normal. Conclusions: StratusOCT provided valuable information, allowing for the exclusion of other disorders that might mimic UAIM. mfERG findings were consistent with transient outer retinal dysfunction as the cause of visual loss. We are unaware of previous reports of UAIM studied by these methods and could find no reference to them in a computerized search using MEDLINE.
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    TOXICITY and RETINAL PENETRATION of INFLIXIMAB in PRIMATES
    (Lippincott Williams & Wilkins, 2012-03-01) Melo, Gustavo B. [UNIFESP]; Moraes Filho, Milton N. [UNIFESP]; Rodrigues, Eduardo B. [UNIFESP]; Regatieri, Caio V. [UNIFESP]; Dreyfuss, Juliana L. [UNIFESP]; Penha, Fernando M. [UNIFESP]; Pinheiro, Marcelo M. [UNIFESP]; Coimbra, Rita C. S. G. [UNIFESP]; Haapalainen, Edna Freymuller [UNIFESP]; Farah, Michel E. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Purpose: To evaluate the retinal penetration and toxicity of two doses of intravitreal infliximab in primates.Methods: Ten marmosets (Callithrix jacchus) were given intravitreal injection of 100 mu g or 400 mu g of infliximab, and balanced salt solution served as control. At baseline and after 24 hours (5 animals) and 7 days (the other 5), the eyes were examined by electroretinography. They were then killed (at 24 hours and 7 days) and assessed by light microscopy and transmission electron microscopy for toxicity and immunohistochemistry, using a biotinylated anti-human immunoglobulin G, to evaluate retinal penetration.Results: There was no difference over 50% of the electroretinography b-wave between baseline and the time points studied in all animals. Light and electron microscopy, and electroretinography analysis, showed no signs of toxicity in any of the animals. Strong presence of infliximab was observed in all retinal layers 7 days after intravitreal injection at both doses (100 and 400 mu g).Conclusion: Infliximab at doses of 100 and 400 mu g seemed to cause no damage to the retina 24 hours and 7 days after its intravitreal injection, and deeply penetrated all its layers, in primates. These results encourage future perspectives for the treatment of chronic inflammatory diseases of the retina in humans. RETINA 32: 606-612, 2012
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    Visual electrophysiologic findings in patients from an extensive Brazilian family with Leber's hereditary optic neuropathy - Visual electrophysiology in LHON
    (Kluwer Academic Publ, 2004-03-01) Salomão, Solange Rios [UNIFESP]; Berezovsky, Adriana [UNIFESP]; Andrade, R. E.; Belfort, R.; Carelli, Valerio; Sadun, Alfredo A.; Universidade Federal de São Paulo (UNIFESP); Univ Bologna; Univ So Calif
    Leber's hereditary optic neuropathy (LHON) is a maternally inherited disease, associated with mitochondrial DNA (mtDNA) point mutations and characterized by bilateral, usually sequential, rapid loss of central vision. the purpose of this study was to investigate electrophysiologically a small cohort of members from an extensive Brazilian family affected by LHON. Pattern-reversal visual evoked potentials (PVEP), and full-field electroretinograms (ERG) were performed on the four index members, all carrying the 11778 homoplasmic mtDNA mutation. They were a 14-year-old recently affected male, his unaffected mother, and her two affected brothers. the three affected members all had bilateral profound visual loss with visual acuities that ranged from 20/250 to CF, cecocentral defects, and severe dyschromatopsia (by FM-100). the unaffected (carrier) female had normal visual acuities, visual fields and color discrimination. Severely prolonged P100 latencies and decreased N75-P100 peak amplitudes were found in pattern-reversal VEPs for three affected members. Normal PVEP responses were found in the carrier female. Rod and cone ERG responses were normal in two affected members, but both the carrier mother and her affected son showed reduced peak-to-peak amplitude for single-flash cone response and 30 Hz flicker, with normal b-wave implicit times. Thus, optic nerve function, evaluated by PVEP, was severely reduced in LHON affected members and normal in the carrier female. However, reduced ERG cone responses suggest that LHON can also affect retinal elements, even in the absence of fundus and other clinical changes that constitute the full and classical expression of LHON.