Navegando por Palavras-chave "endocarditis"

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    Activity of daptomycin and selected antimicrobial agents tested against Staphylococcus aureus from patients with bloodstream infections hospitalized in European medical centers
    (Esift Srl, 2008-02-01) Sader, Helio Silva [UNIFESP]; Watters, A. A.; Fritsche, T. R.; Jones, R. N.; JMI Labs; Universidade Federal de São Paulo (UNIFESP); Tufts Univ
    Daptomycin is a cyclic lipopeptide with potent bactericidal activity against Gram-positive organisms and has been approved by the United States Food and Drug Administration for the treatment of Staphylococcus aureus bacteremia and infectious endocarditis (right-side). We evaluated the activity of daptomycin against bloodstream infection S. aureus strains from 4,799 patients hospitalized in 32 medical centers (12 European countries, Turkey and Israel) with bloodstream infections (BSI) during a 5-year period (2002-2006). Intravenous catheters were the source of infection in 15% of cases, and those strains were analyzed separately. All strains were susceptibility tested by reference broth microdilution methods utilizing calcium supplementation (50 mg/L) when testing daptomycin. Bactericidal activity of daptomycin and vancomycin were evaluated against a subset of 50 randomly selected strains. Daptomycin (MIC (50/90), 0.25/0.5 mg/L), vancomycin (MIC50/90, 1/1 mg/L), and linezolid (MIC50/90, 2/2 mg/L), were highly active (>99.9% susceptibility) against the strains evaluated; and daptomycin was the most potent (lowest MIC90) among these compounds. Resistance rates to oxacillin and levofloxacin were generally elevated, especially when an intravenous catheter was the source of infection.
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    Endocarditis due to glycopeptide-intermediate Staphylococcus aureus: case report and strain characterization
    (Elsevier B.V., 2003-02-01) Andrade-Baiocchi, S.; Tognim, MCB; Baiocchi, Otavio Carvalho Guimarães [UNIFESP]; Sader, H. S.; Universidade Federal de São Paulo (UNIFESP)
    We report a case of infective endocarditis due to vancomycin-intermediate Staphylococcus aureus (VISA) that did not respond to high doses of vancomycin. Initial vancomycin MIC of the last isolate recovered from blood was 8 1 mug/mL, but could be induced up to 32 mug/mL by consecutive growing with vancomycin. Clinical response was only accomplished when linezolid was included in therapy. (C) 2003 Elsevier Science Inc. All rights reserved.