Navegando por Palavras-chave "gabapentin"

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    Estudo randomizado, duplo cego, comparativo com placebo do efeito da gabapentina pré-operatória na intensidade da dor e evolução para dor crônica após operação de síndromedo túnel do carpo
    (Universidade Federal de São Paulo (UNIFESP), 2014-11-26) Sadatsune, Eduardo Jun [UNIFESP]; Sakata, Rioko Kimiko Sakata [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Background and Objectives: Many patients develop chronic pain after hand surgery. Effective perioperative analgesia is important to reduce the incidence of chronic pain. This study evaluated the effect of preoperative gabapentin on postoperative pain intensity and the evolution to chronic pain (neuropathic pain or complex regional pain syndrome) in patients undergoing carpal tunnel syndrome surgery. Methods: Randomized controlled double-blind study was conducted in forty patients aged 18 years or older, both gender, and an ASA physical status I or II, undergoing to the tunnel syndrome surgery, in two groups. There were excluded patients with arrhythmia, myocardial ischemia, cognitive impairment, psychiatric disease, drug abuse, pregnancy, and using opioids, anticonvulsants or antidepressants. Group 1 patients received 600 mg of preoperative gabapentin one hour prior to surgery, and group 2 received placebo. All patients received intravenous regional anesthesia with 20ml 1% lidocaine. When necessary, local infiltration of 1% lidocaine could be used. Midazolam was used for sedation if needed. Acetaminophen (up to 4g/d) was administered for postoperative analgesia as needed. Additional codeine (30mg/d) was used if acetaminophen was insufficient. There were evaluated: postoperative pain intensity (over a 6 month period), need for intra-operative sedation, and use of postoperative acetaminophen and codeine, incidence of postoperative neuropathic pain by DN4 questionnaire and complex regional pain syndrome by the Budapest questionnaire. Results: There was no differences in the need for sedation and complement anesthesia were observed, in postoperative pain intensity, time to first supplementation, need for acetaminophen and codeine supplementation, incidence of chronic pain syndromes (neuropathic or complex regional pain syndrome, and in side effects. Conclusions: Preoperative gabapentin 600 mg did not improve postoperative pain control, and did not reduce the incidence of chronic pain in patients undergoing carpal tunnel syndrome surgery.