Navegando por Palavras-chave "granuloma"

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    Antigenuria and antigenaemia in experimental murine paracoccidioidomycosis
    (Taylor & Francis Ltd, 2005-11-01) Ramos, S. P.; Sano, A.; Ono, M. A.; Camargo, Z. P.; Estevao, D.; Miyaji, M.; Nishimura, K.; Itano, E. N.; Universidade Estadual de Londrina (UEL); Chiba Univ; Universidade Federal de São Paulo (UNIFESP)
    In this study, Swiss mice were experimentally infected with Paracoccidoides brasiliensis (Pb18) and we investigated the levels of gp43 in urine and plasma, anti-gp43 and IgG-gp43 immune complexes in plasma. These levels were correlated with the histopathological findings. Blood and urine samples were collected from mice at 7, 28, 56 and 84 days after intravenous inoculation of 105 yeast cells, and analysed by ELISA. the results showed increased levels of soluble gp43 in the plasma in all periods, and anti-gp43 IgG and immune complexes after day 28. High gp43 levels were detected in the urine, except for day 28, coincident with the presence of compact granulomas in lungs. All the infected mice showed fungal cells in the lungs, with initial granulomatous lesions at day 7, dissemination of lesions to other organs at day 56, and granulomas lacking the surrounding mononuclear cells infiltration, especially at days 56 and 84. Our results suggest that gp43 diffuses passively into the urine, and the determination of gp43 levels in urine samples may be a non-invasive alternative method for diagnosis and follow up of PCM. Further studies are needed to determine if the cellular immune response correlate with decreased urine gp43 levels.
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    Clinical phenotypes in sarcoidosis
    (Lippincott Williams & Wilkins, 2014-09-01) Pereira, Carlos A. C. [UNIFESP]; Dornfeld, Marina C. [UNIFESP]; Baughman, Robert; Judson, Marc A.; Universidade Federal de São Paulo (UNIFESP); Univ Cincinnati; Albany Med Coll
    Purpose of reviewTo describe the methods for derivation of clinical phenotypes in general and how they should be applied in sarcoidosis, taking into account the dimensions of the disease. the results from the small number of studies in this area are summarized.Recent findingsClinical phenotypes are determined-by diverse ways. in sarcoidosis, some studies defined clinical phenotypes based on severity of disease and outcome after treatment of variable duration. A second approach to characterize clinical phenotypes is by using analytic or multivariate techniques. This approach considers several domains of disease and does not make assumptions a priori, with the hypothesis being developed after the results. A small study used factorial analysis for this purpose. Some well defined clinical phenotypes are described and future directions for research are given.SummaryClinical phenotypes, by examining relationships between several domains in sarcoidosis, are likely to better delineate the underlying processes and pathways. Larger studies with appropriate methods should be performed to better delineate clinical phenotypes in sarcoidosis.
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    Importance of glottic configuration in the development of posterior laryngeal granuloma
    (Annals Publ Co, 2001-08-01) Pontes, Paulo [UNIFESP]; De Biase, Noemi Grigoletto [UNIFESP]; Kyrillos, Leny Cristina Rodrigues [UNIFESP]; Pontes, Antonio [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Pontificia Univ Catolica
    Posterior laryngeal granuloma is frequently related to 3 predisposing factors: vocal abuse, gastroesophageal reflux disease, and orotracheal intubation. It is strongly predominant in men and rare in women, except under postintubation circumstances, in which the incidence is higher in women. The aim of this study was to characterize laryngeal conformations for each sex that, whenever associated with different causes, may lead to the onset and particular location of granulomas, according to a main predisposing factor. Sixty-six subjects whose ages ranged from 18 to 73 years were studied. They were distributed into 4 groups according to the predominant cause of granuloma: intubation, vocal abuse, gastroesophageal reflux, and idiopathic causes. The larynx was evaluated during breathing, and the glottic proportion (GP) was measured. Glottic proportion is the mathematical ratio between the midsagittal dimension of the intermembranous region and that of the intercartilaginous region of the larynx during inhalation. Its measurement was feasible in 57 patients. The groups that had a causative factor other than laryngeal orotracheal intubation had GP values statistically similar to those of each other and to the control group of men, ie, close to 1.2. The postintubation group had GP values similar to the control group of women, ie, close to 1.0; this proportion protects the arytenoid region in women's larynges when there is effort during vocal production, but makes women susceptible to orotracheal postintubation granuloma.
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    Kinetics of mobilization and differentiation of lymphohematopoietic cells during experimental murine schistosomiasis in galectin-3(-/-) mice
    (Federation Amer Soc Exp Biol, 2007-08-01) Oliveira, F. L.; Frazao, P.; Chammas, Roger [UNIFESP]; Hsu, D. K.; Liu, F. T.; Borojevic, Radovan; Takiya, C. M.; El-Cheikh, M. C.; Universidade Federal do Rio de Janeiro (UFRJ); Universidade Federal de São Paulo (UNIFESP); CEPID FAPESP; Univ Calif Davis
    Galectin-3 (gal-3), a beta-galactoside-binding animal lectin, plays a role in cell-cell and cell-extracellular matrix interactions. Extracellular gal-3 modulates cell migration and adhesion in several physiological and pathological processes. Gal-3 is highly expressed in activated macrophages. Schistosoma mansoni eggs display a large amount of gal-3 ligands on their surface and elicit a well-characterized, macrophage-dependent, granulomatous, inflammatory reaction. Here, we have investigated the acute and chronic phases of S. mansoni infection in wild-type and gal-3(-/-) mice. in the absence of gal-3, chronic-phase granulomas were smaller in diameter, displaying thinner collagen fibers with a loose orientation. Schistosoma-infected gal-3(-/-) mice had remarkable changes in the monocyte/ macrophage, eosinophil, and B lymphocyte subpopulations as compared with the infected wild- type mice. We observed a reduction of macrophage number, an increase in eosinophil absolute number, and a decrease in B lymphocyte subpopulation (B220(+/high) cells) in the periphery during the evolution of the disease in gal-3(-/-) mice. B lymphopenia was followed by an increase of plasma cell number in bone marrow, spleen, and mesenteric lymph nodes of the infected gal-3(-/-) mice. the plasma IgG and IgE levels also increased in these mice. Gal-3 plays a role in the organization, collagen distribution, and mobilization of inflammatory cells to chronic-phase granulomas, niches for extramedullary myelopoiesis, besides interfering with monocyte-to-macrophage and B cell-to-plasma cell differentiation.
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    M2 macrophage is the predominant phenotype in airways inflammatory lesions in patients with granulomatosis with polyangiitis
    (Biomed Central Ltd, 2017) Silva de Souza, Alexandre Wagner [UNIFESP]; van Timmeren, Mirjan; Sanders, Jan-Stephan; Stegeman, Coen; Heeringa, Peter; Kallenberg, Cees G. M.; Westra, Johanna
    Background: Macrophages may present two distinct phenotypes indicated as M1 and M2 under different stimuli. M1 and M2 macrophages have divergent functions that range from enhancement of inflammation for M1 to tissue repair and remodeling for M2 macrophages. The objective of this study was to evaluate the distribution of M1 and M2 macrophage phenotypes in biopsies from the airways of patients with active granulomatosis with polyangiitis (GPA) and to analyze their associations with T and B cells in those biopsies, and with nasal carriage of Staphylococcus aureus, disease parameters and therapy. Methods: Consecutive GPA patients (n = 35) with active airway disease, who underwent respiratory tract biopsy were included. Immunohistochemical evaluation was performed to assess the distribution of macrophages and T and B cells using the markers CD68, CD3 and CD20, respectively. CD86 was used as the M1 marker and CD163 as the M2 marker while Tbet and GATA-3 were used as Th1 and Th2 markers, respectively. At the time of the biopsy patients were assessed for nasal carriage of Staphylococcus aureus and treatment. Results: Percentages of macrophages and T cells were significantly higher than those of B cells in lesional tissue from the respiratory tract in GPA. M2 macrophages and Th2 cells were more frequent than M1 macrophages (p = 0.0007) and Th1 cells (p < 0.0001), respectively. Percentages of T cells were higher in nose biopsies than in biopsies from other sites (p = 0.021)
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    Post-stapedotomy granulomatous reaction
    (Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, 2010-01-01) Yonamine, Fernando Kaoru [UNIFESP]; Segalla, Danilo Kanashiro; Antunes, Marcos Luiz [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Diadema State Hosp
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    Spinal cord compression secondary to epidural bilharzioma: Case report
    (Blackwell Publishing, 2007-10-01) Maia, Antonio C. M.; Silva, Luciano R. F.; Guimaraes, Matheus D.; Gomes, Francinaldo L.; Bichuetti, Denis B.; Stavale, Joao N.; Prandini, Mirto N.; Universidade Federal de São Paulo (UNIFESP)
    A case of an epidural granuloma due to Schistosoma mansoni compressing the spinal cord at T7-T9 is presented. the patient, a 35-year-old Brazilian man, started complaining of recurrent back pain since 2003. A magnetic resonance imaging (MRI) scan showed a large epidural mass extending from T7 to T9 and causing mild spinal cord compression. Through a bilateral laminectomy the bilharzioma was subtotally removed without significant bleeding. the histopathology confirmed the diagnosis of granuloma due to S. mansoni. the patient recovered completely. Although the MRI is nonspecific, this differential diagnosis should be included in homogeneous epidural lesions without bone involvement, more than ever in endemic countries or during the evaluation of travelers to those regions.