Navegando por Palavras-chave "homocisteína"

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    Alzheimer's disease in Brazilian elderly has a relation with homocysteine but not with MTHFR polymorphisms
    (Academia Brasileira de Neurologia - ABNEURO, 2006-12-01) Silva, Vanessa Cavalcante da; Ramos, Flávio José da Costa; Freitas, Elizabete Malaquias; Brito-marques, Paulo Roberto de; Cavalcanti, Márcia Nery de Holanda; D'Almeida, Vânia [UNIFESP]; Cabral-filho, José Eulálio; Muniz, Maria Tereza Cartaxo; Universidade de Pernambuco Instituto de Ciências Biológicas; Universidade de Pernambuco Faculdade de Ciências Médicas Departamento de Neurologia; Universidade Federal de São Paulo (UNIFESP); Instituto Materno-Infantil de Pernambuco
    OBJECTIVE: To investigate the association between total plasma homocysteine concentration, C677T and A1298C polymorphisms in MTHFR gene and Alzheimer's disease (AD) development. METHOD: Forty-three patients with probable (63%) and possible (37%) AD and 50 non-demented controls were evaluated. Groups did not differ as to gender, age, scholar years, diabetes, alcohol and coffee intake and physical activity. Total plasma homocysteine (Hcy) levels were determined by HPLC and genotyping for MTHFR by PCR/RFLP. Mann-Whitney U test was used to compare quantitative variable, Fisher-Freeman-Halton test to compare genotypes and allele proportions and Chi-square test to other qualitative variables. RESULTS: AD patients presented higher total plasma Hcy levels than controls and the difference was statistically significant. No differences in the C677T and A1298C MTHFR polymorphisms distributions were found between patients and controls. Plasma homocysteine concentration did not change with MTHFR genotypes. CONCLUSION: Our data confirms the association between increased plasma Hcy concentration and AD and suggests that neither C677T nor A1298C MTHFR polymorphisms contributed to genetic susceptibility for AD in elderly individuals in the Northeast of Brazil.
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    Hiperhomocisteinemia na insuficiência renal crônica
    (Pontifícia Universidade Católica de Campinas, 2005-04-01) Nerbass, Fabiana Baggio [UNIFESP]; Draibe, Sergio Antonio [UNIFESP]; Cuppari, Lilian [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Homocysteine is a sulfur-containing amino acid derived from the metabolism of methionine, whose abnormal accumulation in plasma is a risk factor for vascular disease in the general population and in patients with chronic renal disease. In these patients, the prevalence of individuals with hyperhomocysteinemia is very high, even in the pre-dialysis stage of the disease. The main factor that seems to be implicated on the elevation of homocysteine levels in this population is the renal mass loss, considering that the kidney has an important role in the metabolism of such amino acid. The treatment of hyperhomocysteinemia consists on supplementation of the vitamins that are involved in the homocysteine metabolism (folate, B6 and B12.). However, for chronic renal disease patients, this treatment is not completely effective, because although it promotes reduction of homocysteine levels, the normalization is not reached in the majority of the patients. This study reviews the hyperhomocysteinemia etiology on chronic renal disease, its main determinants, its relationship with vascular diseases, and the modes of treatment.