Navegando por Palavras-chave "impairment"

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    Fobia social: estudo da prevalência em duas escolas em Porto Alegre
    (Instituto de Psiquiatria da Universidade Federal do Rio de Janeiro, 2008-01-01) Fernandes, Gabrielly Cruvinel; Terra, Mauro Barbosa [UNIFESP]; Universidade Federal de Ciências da Saúde de Porto Alegre; Centro de Estudos José de Barros Falcão; Universidade Federal de São Paulo (UNIFESP)
    Social phobia is frequent among adolescents, and its identification and determination of potential impairments are of great importance. OBJECTIVES: To report the prevalence and impact of social phobia on education in a sample of adolescents. METHODS: The Social Phobia Inventory (SPIN) was administered to 525 students of primary and high school, of both genders, in one public and one private school in the city of Porto Alegre, Brazil, but 32 students were excluded from the study due to incomplete answers. A sociodemographic questionnaire were also administered. RESULTS: According to the SPIN, 114 of 493 (23.12%) students obtained scores equal to or greater than 19 points, indicating the presence of symptoms compatible with diagnosis of social phobia. Girls tended to show a greater frequency of social anxiety disorder when compared to boys (p = 0.053). Social phobia was not associated with school repetition. CONCLUSIONS: Social phobia symptoms are common among teenagers and, due to its chronic course, may result in severe impairments. In this study, a correlation between social phobia and school repetition was not found. However, early identification and treatment of such disorder is extremely important.
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    Interaction between M1-muscarinic and glutamatergic NMDA receptors on an inhibitory avoidance task
    (Elsevier B.V., 2005-11-30) Moreira, K. M.; Ferreira, T. L.; Fornari, R. V.; Figueredo, LZP; Oliveira, MGM; Universidade Federal de São Paulo (UNIFESP)
    It has been demonstrated that MK-801 potentiates the effects of the non-selective muscarinic antagonist scopolamine on memory in rats. in this study, we investigated the role of the M1-muscarinic receptor in this interaction, by administering different doses of dicyclomine (DIC) and MK-801 in combination to male Wistar rats before training on the inhibitory avoidance task. MK-801 and DIC in sub-effective doses were administered in combination. It was observed that MK-801 at a dose of 0.1125 mg/kg with a sub-effective dose of 8 mg/kg of DIC significantly impaired the retention test when compared with saline-treated animals, i.e. MK-801 potentiated the effects of dicyclomine on memory impairment. Our results suggest an important role for the M1-muscarinic receptor in the synergistic interaction between cholinergic muscarinic and glutamatergic NMDA receptors, which is in line with the findings that the interactive modulation between these two neurotransmitters systems constitutes an important mechanism in cognitive functions. (c) 2005 Elsevier Inc. All rights reserved.