Navegando por Palavras-chave "in vivo studies"

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    Fluoride Induces Apoptosis in Mammalian Cells: In Vitro and In Vivo Studies
    (Int Inst Anticancer Research, 2017) Ribeiro, Daniel Araki [UNIFESP]; Cardoso, Caroline Margonato [UNIFESP]; Yujra, Veronica Quispe [UNIFESP]; Viana, Milena de Barros [UNIFESP]; Aguiar, Odair [UNIFESP]; Pisani, Luciana Pellegrini [UNIFESP]; Oshima, Celina Tizuko Fujiyama [UNIFESP]
    Apoptosis is genetically programmed cell death, an irreversible process of cell senescence with characteristic features different from other cellular mechanisms of death such as necrosis. In the last years, apoptosis has been extensively studied in the scientific literature, because it has been established that apoptosis plays a crucial role following the time course of chronic degenerative diseases, such as cancer. Thus, several researchers have strugged to detect what chemical agents are able to inter fere with the apoptotic process. Thus, the purpose of this literature review is to assess if fluoride induces apoptosis in mammalian cells using in vivo and in vitro test systems. Certain mammalian cell types such as oral cells, blood and brain were exetensively investigated