Navegando por Palavras-chave "keloid"

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    Control of the skin scarring response
    (Academia Brasileira de Ciências, 2009-09-01) Ferreira, Lydia Masako [UNIFESP]; Gragnani, Alfredo [UNIFESP]; Furtado, Fabianne [UNIFESP]; Hochman, Bernardo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    There comes a time when the understanding of the cutaneous healing process becomes essential due to the need for a precocious tissue repair to reduce the physical, social, and psychological morbidity. Advances in the knowledge on the control of interaction among cells, matrix and growth factors will provide more information on the Regenerative Medicine, an emerging area of research in medical bioengineering. However, considering the dynamism and complexity of the cutaneous healing response, it is fundamental to understand the control mechanism exerted by the interaction and synergism of both systems, cutaneous nervous and central nervous, via hypothalamus hypophysis-adrenal axis, a relevant subject, but hardly ever explored. The present study reviews the neuro-immune-endocrine physiology of the skin responsible for its multiple functions and the extreme disturbances of the healing process, like the excess and deficiency of the extracellular matrix deposition.
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    Keloid explant culture: a model for keloid fibroblasts isolation and cultivation based on the biological differences of its specific regions
    (Wiley-Blackwell, 2010-10-01) Tucci-Viegas, Vanina Monique [UNIFESP]; Hochman, Bernardo [UNIFESP]; Franca, Jeronimo P. [UNIFESP]; Ferreira, Lydia M. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    In vitro studies with keloid fibroblasts frequently present contradictory results. This may occur because keloids present distinct genotypic and phenotypic characteristics in its different regions, such as the peripheral region in relation to the central region. We suggest an explant model for keloid fibroblasts harvesting, standardising the initial processing of keloid samples to obtain fragments from different regions, considering its biological differences, for primary cell culture. the different keloid regions were delimited and fragments were obtained using a 3-mm diameter punch. To remove fragments from the periphery, the punch was placed in one longitudinal line extremity, respecting the lesion borders. for the central region, it was placed in the intersection of lines at the level of the largest longitudinal and transversal axes, the other fragments being removed centrifugally in relation to the first one. Primary fibroblast culture was carried out by explant. Flow cytometry analysis showed cell cycle differences between the groups, confirming its different origins and biological characteristics. in conclusion, our proposed model proved itself efficient for keloid fibroblast isolation from specific regions and cultivation. Its simplicity and ease of execution may turn it into an important tool for studying the characteristics of the different keloid-derived fibroblasts in culture.
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    Keloids: a new challenge for nutrition
    (Wiley-Blackwell, 2010-07-01) Bersch-Ferreira, Ângela Cristine [UNIFESP]; Hochman, Bernardo [UNIFESP]; Furtado, Fabianne [UNIFESP]; Bonatti, Silvilena [UNIFESP]; Ferreira, Lydia Masako [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Keloids are the result of a dysfunctional scarring process that leads to excessive deposition of extracellular matrix in susceptible individuals, causing them physical, psychological, and social discomfort. Many studies have investigated various aspects of keloid physiopathology; however, the relationship between dietary components and keloids has not received much attention. the present literature review was conducted to examine the available evidence related to the relationships between nutrition/nutrients and keloids. Findings from in vitro and in vivo studies indicate possible associations exist between keloids and fatty acids, soluble fibers, and phytochemicals. However, these relationships have not been fully explored and new studies need to be carried out before any efficient diet-based therapy can be prescribed for the prevention and treatment of keloids.
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    Multicenter study of wound healing in neurofibromatosis and neurofibroma
    (Lippincott Williams & Wilkins, 2007-09-01) Miyawaki, Takeshi; Billings, Brian; Har-Shai, Yaron; Agbenorku, Pius; Kokuba, Elisa [UNIFESP]; Moreira-Gonzalez, Andrea [UNIFESP]; Tsukuno, Mari; Kurihara, Kunihiro; Jackson, Ian T.; Providence Hosp; Jikei Univ; Universidade Federal de São Paulo (UNIFESP); Lady Davis Carmel Med Ctr
    Based on clinical experience, the senior author has become convinced that wounds produced to correct the deformities of patients with neurofibromatosis (NF-1) have produced remarkably good scars, the interesting feature being that progression to keloid or hypertrophic scar is rare. The other point noted was that this situation did not change, no matter the patient's race or skin color. There have been few reports describing or discussing this hypothesis. The purpose of this study was to investigate whether wounds produced in the patients with NF-1 produce keloid or hypertrophic scars. The patients with solitary neurofibroma were also included in this study; these were compared with the NF-1 group. This was conducted as a multicenter study. Patients with neurofibromatosis/solitary neurofibroma, who were operated on from 1990 to 2000, were evaluated by reviewing their medical charts and photographs retrospectively. The patients were treated in centers from five different countries. The analysis was undertaken based on the following points: 1) age and sex at surgery; 2) race of the patients; 3) past and family histories of hypertrophic scar and keloid; 4) surgical site(s); 5) diagnosis, NF1 or solitary neurofibroma; 6) surgical complications; 7) number of reoperations to manage the complications; 8) adjuvant therapy for the tumor; 9) depth of the tumors; and 10) incidence of malignant degeneration. A total of 101 cases with neurofibromatosis or solitary neurofibroma was analyzed. The age at surgery ranged from 1 year 6 months to 74 years; sex ratio was 47 males and 54 females. The racial distribution of the patients was 13 white, 13 black, 3 Hispanic, and 58 Asian. There was no past or family history of hypertrophic scar or keloid. The surgical sites were head and neck in 70 cases, trunk in 20 cases, upper extremities in 22 cases, and lower extremities in 20 cases. The clinical diagnosis was NF-1 in W cases, solitary neurofibroma in 35 cases, plexiform neurofibroma in four cases, and no distinct clinical diagnosis in five cases. There were no other types of neurofibiomatosis. Hematoma and white wide scar were the main postoperative complications found in six cases of NF-1. Infection was also noted in four cases. However, no patient developed hypertrophic scar or keloid in the neurofibromatosis group, whereas two cases showed hypertrophic scar in the solitary neurofibroma group. The outcome showed that the patients with NF-1 and plexiform neurofibroma, no matter the racial group, produce good scars without keloid or hypertrophic changes, whereas solitary neurofibroma has a potential to cause hypertrophic scar.
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    Nerve fibres: a possible role in keloid pathogenesis
    (Blackwell Publishing, 2008-03-01) Hochman, B. [UNIFESP]; Nahas, F. X. [UNIFESP]; Sobral, C. S. [UNIFESP]; Locali, R. F. [UNIFESP]; Juliano, Y. [UNIFESP]; Ferreira, L. M. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)