Navegando por Palavras-chave "magnésio"

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    Avaliação do efeito analgésico da associação de magnésio com morfina na dor de pacientes com câncer: estudo clínico randomizado duplo-cego
    (Universidade Federal de São Paulo (UNIFESP), 2015-07-31) Baaklini, Luis Gustavo [UNIFESP]; Sakata, Rioko Kimiko Sakata [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    Objectives: The aim of this study was to evaluate if the association of Mg enhances the analgesic effect of morphine in cancer pain. Methods: The study was prospective, randomized, double-blinded, and comparative with placebo. There were studied 40 patients, with more than 18 years, of both genders, with cancer pain, using morphine (third analgesic step recommended by WHO). There were excluded patients with hypersensitivity to drugs, and pregnant. Group 1 patients received oral 656,6mg magnesium sulfate twice daily; group 2 patients received placebo twice a day, in identical capsules. All patients received morphine as needed. Acetaminophen was associated at doses of 2 to 3 g / day (every 4 to 6 h). Adjuvant drugs could be used when indicated. Pain intensity was evaluated by numerical scale from zero to 10 in the first consultation and after 1, 2, 3, and 4 wk. The patient noted the intensity of pain and side effects in a file. The functional performance of Karnofsky (KPS) and the quality of life by QLQ-C30 were evaluated in the 1st consultation and after 4 wk. Results: There was no difference between groups in pain intensity, doses of morphine, functional performance, quality of life and side effects. There was a significant reduction in pain intensity in both groups. There was a increased dose of morphine in G2. Conclusions: The association of magnesium sulfate (656,6mg) to morphine in cancer patients did not improve the analgesic effect, functional performance and quality of life; and did not reduce the side effects; but promoted less need to increase the dose of morphine.
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    Serum levels of magnesium in sudden cardiac deaths among people with schizophrenia: hit or miss?
    (Academia Brasileira de Neurologia - ABNEURO, 2012-10-01) Scorza, Fulvio Alexandre [UNIFESP]; Albuquerque, Marly de [UNIFESP]; Arida, Ricardo Mario [UNIFESP]; Cysneiros, Roberta Monterazzo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Presbiteriana Mackenzie
    Schizophrenia is a devastating mental disorder, affecting cognitive, emotional, and behavioral conditions, ability to work, social functioning, family stability and self-esteem of the patient. People with schizophrenia show a two to three-fold increased risk to die prematurely than those without schizophrenia. Understanding the mechanisms behind sudden cardiac death in individuals with schizophrenia is a key to prevention. Although different mechanisms may be related, there are clear indications that cardiac abnormalities play a potential role. Some antipsychotics may be associated with cardiovascular adverse events, e.g., QT interval prolongation, metabolic dysfunction, blood pressure and heart rate alterations. Magnesium (Mg) abnormalities may lead to various morphological and functional dysfunctions of the heart and low levels of serum Mg are considered to be at high risk for sudden cardiac death. As low serum Mg is associated with detrimental effects on the heart and that antipsychotic-treated schizophrenia patients frequently affect the heart rate, possibly, these factors together must change the normal functioning of the heart and consequently being able to culminate in a catastrophic event.
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    Serum magnesium: a clinical biomarker for sudden unexpected death in epilepsy?
    (Liga Brasileira de Epilepsia (LBE), 2011-01-01) Terra, Vera Cristina; Albuquerque, Marly de [UNIFESP]; Scorza, Carla Alessandra [UNIFESP]; Arida, Ricardo Mario [UNIFESP]; Scorza, Fulvio Alexandre [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    INTRODUCTION: Epilepsy is one of the most common chronic neurological disorder in the world and has a higher mortality rate than would be expected in a healthy population. One of the most related category of death is sudden unexpected death in epilepsy (SUDEP). Many risk factors have been related to SUDEP, but the mechanisms involved in its genesis is still unknown. OBJECTIVE: Here we describe one case of a patient with low serum magnesium levels that suffered of SUDEP. CONCLUSION: we discuss a possible cause-effect relation, suggesting that magnesium may be, in some cases, a biomarker of SUDEP.