Navegando por Palavras-chave "mammography"
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- ItemSomente MetadadadosAspectos de imagem dos sarcomas primários da mama: revisão da literatura e série de casos(Universidade Federal de São Paulo (UNIFESP), 2016-12-21) Alves, Aldo Maurici Araujo [UNIFESP]; Mello, Giselle Guedes Netto de Mello [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: To review the imaging aspects of primary breast sarcomas (PMS). Methods: a qualitative observational study through a series of case reports and literature revision. Cases of PMS were collected with histopathological confirmation And accessible imaging (mammography, ultrasound or magnetic resonance imaging), From two university hospitals and a private service. The literature review was Performed through the search of indexed works in the MEDLINE database. Results: 10 cases were found within the selection criteria, and their respective Findings were presented and discussed together with the literature. Conclusion: there is significant overlap between the mammographic findings, And magnetic resonance imaging of mammary carcinomas and sarcomas. However, a rapidly growing circumscribed mass without calcifications in the Mammography, without axillary lymph node involvement, complex-appearing solid-cystic On ultrasound and magnetic resonance imaging may suggest a PMS.
- ItemSomente MetadadadosCorrelação entre mamografia, escore de cálcio e doença coronariana em mulheres assintomáticas de risco intermediário pelo escore de framingham(Universidade Federal de São Paulo (UNIFESP), 2015) Timbo, Luciana Satiro [UNIFESP]; Szarf, Gilberto Szarf [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objectives: to correlate the presence and intensity of breast arterial calcifications (BAC) with the coronary calcium score (CCS) and the risk of developing myocardial ischemia, stroke, heart attack and death from coronary causes in five years in patients at intermediate risk by Framingham criteria. Methods: 45 patients at intermediate risk with previous indication of routine mammography, performed CCS. Each method was analyzed separately by specialist physicians without knowledge of the results. The presence and intensity of BAC were graded as follows: absent (no vascular calcifications); slight (one vascular segment), moderate (one whole vessel) and severe (two or more vessels). CCS was rated at zero, slight (1-100), moderate (101-300) and severe (greater than 300). The data were compared using appropriate statistical tools. The patients will be followed for five years. Results: the mean age was 59,6 years. The finding of BAC was diagnosed in 15 patients (4 slight, 3 moderate and 8 severe), 38, not present. The CCS was abnormal in 20 cases (10 slight, 6 moderate and 4 severe) and equal to zero in 33. There was predominance of absence of BAC and zero CCS in patients with low Framingham score. It was observed that exists a statistically significant association (p <0.05) between the presence of intramammary and coronary vascular calcifications. Intensity correlation between methods was not found. Among the risk factors evaluated for coronary artery disease, there was association statistically significant (p <0.05) between age and breast arterial calcfications, as well as age and coronary calcifications. So far, no cardiovascular event was noted. Conclusions: there is relationship between BAC and CCS in women at intermediate risk of cardiovascular disease; intensity correlation between methods was not significant; in the first 20 months of this ongoing research, no case of myocardial ischemia, stroke, heart attack and death from coronary causes was observed
- ItemSomente MetadadadosCorrelação entre mamografia, escore de cálcio e doença coronariana em mulheres assintomáticas de risco intermediário pelo escore de framingham(Universidade Federal de São Paulo (UNIFESP), 2013-11-29) Timbo, Luciana Satiro [UNIFESP]; Szarf, Gilberto Szarf [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objectives: to correlate the presence and intensity of breast arterial calcifications (BAC) with the coronary calcium score (CCS) and the risk of developing myocardial ischemia, stroke, heart attack and death from coronary causes in five years in patients at intermediate risk by Framingham criteria. Methods: 45 patients at intermediate risk with previous indication of routine mammography, performed CCS. Each method was analyzed separately by specialist physicians without knowledge of the results. The presence and intensity of BAC were graded as follows: absent (no vascular calcifications); slight (one vascular segment), moderate (one whole vessel) and severe (two or more vessels). CCS was rated at zero, slight (1-100), moderate (101-300) and severe (greater than 300). The data were compared using appropriate statistical tools. The patients will be followed for five years. Results: the mean age was 59,6 years. The finding of BAC was diagnosed in 15 patients (4 slight, 3 moderate and 8 severe), 38, not present. The CCS was abnormal in 20 cases (10 slight, 6 moderate and 4 severe) and equal to zero in 33. There was predominance of absence of BAC and zero CCS in patients with low Framingham score. It was observed that exists a statistically significant association (p <0.05) between the presence of intramammary and coronary vascular calcifications. Intensity correlation between methods was not found. Among the risk factors evaluated for coronary artery disease, there was association statistically significant (p <0.05) between age and breast arterial calcfications, as well as age and coronary calcifications. So far, no cardiovascular event was noted. Conclusions: there is relationship between BAC and CCS in women at intermediate risk of cardiovascular disease; intensity correlation between methods was not significant; in the first 20 months of this ongoing research, no case of myocardial ischemia, stroke, heart attack and death from coronary causes was observed
- ItemAcesso aberto (Open Access)Densidade mamográfica e polimorfismos do gene do receptor de estrogênio MspI e do receptor de progesterona PROGINS em índias do estado do Amapá(Universidade Federal de São Paulo (UNIFESP), 2013-08-28) Secco, Jose Mauro [UNIFESP]; Nazario, Afonso Celso Pinto [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Background: Mammographic density is known to be one of the main risk factors for breast cancer and presents individual variations due to various factors. It is also of scientific knowledge that the indigenous groups present less dense breasts compared with non-indigenous populations, and that breast cancer is rare in this ethnic group. This study aims to evaluate the clinical characteristics of indigenous population of the state of Amapá and also the MspI and PROGINS polymorphisms of the estrogen and progesterone receptor genes, associating them with the mammographic density in indians who had never undergone mammography. Knowing that the clinical characteristics and sex steroids affect mammographic density, we sought the finding of low mammographic density in this population and some explanation for the difference in mammographic density and in breast cancer incidence. Methods: We studied 135 women of indian ethnicity without clinical or mammographic alterations and who had never used hormone therapy. All of them were transported to the state capital Macapá to undergo interview, bilateral mammography and collection of biological material. The interview was held at the Indian House through local interpreter; mammographic density was determined by three independent observers, two subjective evaluations were based on the classification of the ACR-BI-RADS® 2003 and another was computerized (software Adobe PhotoshopÒ, v. 10.0). Blood samples were taken for DNA extraction according to the illustra Kit protocol (GE Healthcare) and then PCRRFLP (polymerase chain reaction - restriction fragment polymorphism length) was held for analysis of MspI and PROGINS polymorphisms in the estrogen and the progesterone receptor genes. Result: High agreement was found in mammographic density between observers through Pearson's correlation coefficients R, Spearman Correlation and Kappa, with p = 0.001. We found 82% of Indian women with not dense breasts and 18% with dense breasts, with a mean age of 50.4 years. The clinical characteristics associated with mammographic density were age (p = 0.0001), FSH levels (p < 0.001) and estrogen levels (p < 0.01). There was no statistical difference between the groups of dense and not dense breasts for PROGINS and ER-MspI polymorphisms genotypes. Conclusion: Mammographic density in indian women is predominantly low, regardless of menopausal status. Mammographic density is significantly associated with age menopausal status, FSH and E2 levels in this population. The PROGINS polymorphism was found in 3.7% of the women and Mspl in 84.4%. No correlation was found of polymorphism with mammographic density.
- ItemSomente MetadadadosEstudo longitudinal da qualidade da imagem mamográfica em sistemas digitais associado ao processo de otimização da dose glandular média(Universidade Federal de São Paulo (UNIFESP), 2014-06-11) Alves, Fatima Faloppa Rodrigues [UNIFESP]; Medeiros, Regina Bitelli Medeiros [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: Contribute to the development of practices that may assist AGD?s optimization process associated to image quality in digital systems (CR and DR). Method: Two pieces of mammographic equipment (Lorad and Performa) were tested regarding performance with CR Kodak system and with Digital mammographic equipment (DR) GE, and image viewing systems have been assessed in the period between January/ 2012 to January/2014. IPS uniformity was checked in outpatient routine until July/2013 and, after their replacement, in October/2013. AGDs were calculated using PMMA semicircular plates with 1 and 2 mm thickness, and physical properties of images were assessed through quality parameters: FTM, SNR, CNR and FOM. Regarding breast tissue, AGDs were estimated in MLOE projection according to mammographic density through a databank with information from 1071 patients including: age, biometry and operational technical data of the exams. An electronic spreadsheet made it possible to obtain mAs values so as to keep AGDs below European protocol limits, and, at the same time, to maximize CNR values. Simulated image quality and structure detection were performed with CIRS-11A phantom. Mammographic image quality was analyzed based on the quality criteria recommended by IAEA. Results: IPs uniformity ranged between 9,9% and 92,3% from January/ 2012 to July/2013, and after these IPs were changed, uniformity ranged less than 7%. AGD values were above Euref?s limits for both PMMA and breast tissue, for most of the period between March/2012 and July/2013, in Lorad and Performa equipment. In the Digital System, AGDs remained within Euref?s PMMA and breast tissue limits. However, regarding mammographic density, AGDs were inferior in the Digital System. FTM, SNR and CNR parameters remained above Euref?s reference limits in the same period in which nonconformity of IPs? uniformity was observed. After IPs were replaced, mAs was on average reduced in 30% and 10%, with average CNR gain of 13% and 7% in Lorad and Performa equipment. Detection simulator?s structure ranged between 0,165 and 0,275mm for microcalcification and between 1,19 and 2,38mm for tumor mass, but there was no variation in detection of fibers. In clinical image analysis, although 99% of the images were considered acceptable for diagnosis, in 62% of the cases it was not possible to view the pectoral muscle in left CC positioning, and in 44% the angle of inframammary fold in left MLO projection, which can be attributed to positioning error. Specific viewbox luminance values were out of the limits set by the norm 543/98. Monitors had luminance superior to 500cd/m2. Conclusion: It is suggested, as a practical method, monthly CNR and SNR analysis, and the use of an electronic spreadsheet is suggested, so as to reduce time and make AGDs optimization process easier. The deterioration of IPs caused increase in AGDs, loss in image quality and variation in uniformity, in SNR, in FTM and in FOM which points to the necessity of establishing an IP uniformity base line and other quality parameters. Monitoring quality of clinical images allowed the detection of failures in positioning, highlighting the need for training. AGDs that were calculated in Digital System were inferior to the CR system, showing differences between technological characteristics. The use of different target/filter combinations, as well as a superior output in Digital System, may have contributed to achieving lower doses. It stresses the necessity to establish specific quality tests and to establish a revision of norms for Digital Systems in Brazil.
- ItemSomente MetadadadosPolymorphisms of estrogen receptor-alpha gene in Brazilian women with high breast density after menopause(Informa Healthcare, 2013-08-01) Souza, Marilene Alicia; Fonseca, Angela Maggio; Bagnoli, Vicente R.; Barros, Nestor de; Franzolin, Solange O. B.; Carvalho, Katia C.; Soares Junior, José Maria [UNIFESP]; Baracat, Edmund C.; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)The association of genetic polymorphism in the estrogen receptor alpha (ER alpha) gene and risk for diseases including breast cancer (BC) has been the subject of great interest.Objective: Checking on women with high breast density after menopause, the frequency of the Pvull and Xbal polymorphisms of the ER alpha gene and the correlation between them and the known risk factors for breast cancer.Method: Observational study with 308 women between 45 and 65 years old with high breast density, without hormonal therapy, menstruation for a year or more, breast and ovarian cancer history. It was characterized in clinical history and physical examination: menarche, menopause, parity, family history of BC, smoking, alcohol intake and body mass index.Results: the allelic and genotypic frequencies for ER alpha-Pvull and Xbal: p = 43.99%; p = 56.01%; pp = 32.14%; Pp = 47.73% and PP = 20.13%; X = 41.56%; x = 58.44%; xx = 33.44%; Xx = 50.00% and XX = 16.56%, respectively. the most frequent risk factors for BC: menarche before 12 years old (35.38%), nulliparity or first child after 28 years old (41.66%), family history of BC (19.16%) and overweight/obesity (62.01%).Conclusion: Allelic and genotypic distribution similar to literature. the risk factors for BC were more prevalent in women with high breast density but without significant associations with these polymorphisms.
- ItemSomente MetadadadosSonographic and mammographic findings of breast liquid silicone injection(Wiley-Blackwell, 2006-07-01) Scaranelo, Anabel Medeiros; Ribeiro Maia, Maria de Fatima; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Rio de Janeiro (UFRJ)Purpose. To describe the sonographic and mammographic features of patients whose breasts have been injected with silicone.Methods. Between July 1997 and August 1999, 14 patients with a history of breast injection of liquid silicone underwent physical, mammographic, and sonographic examination. Mammographic findings were classified as macronodular, micronodular, or mixed striated patterns. Sonographic appearances were classified as macronodular, micronodular, mixed, or snowstorm patterns.Results. Eighty-six percent of the patients had abnormal physical examination. Well-defined nodules were palpable in 4 patients, 6 patients had diffusely heterogeneous breasts on palpation, and 2 patients had a combination of heterogeneous texture with dominant nodules. Sonographic examination revealed the presence of marked echogenicity (i.e., snowstorm pattern) in all 14 patients; in 11 patients it was associated with macronodules and/or micronodules, whereas in 3 patients only snowstorm appearance was noted. Mammographic patterns were macronodular in 7 patients and mixed macronodular and micronodular in 6 patients.Conclusions. Both mammography and sonography can help identify free silicone injected directly into the breast. (C) 2006 Wiley Periodicals, Inc.