Navegando por Palavras-chave "metastases"
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- ItemSomente MetadadadosEnzyme and integrin expression by high and low metastatic melanoma cell lines(Lippincott Williams & Wilkins, 2003-02-01) Staquicini, F. I.; Moreira, C. R.; Nascimento, F. D.; Tersariol, ILS; Nader, H. B.; Dietrich, C. P.; Lopes, J. D.; Universidade Federal de São Paulo (UNIFESP); Univ Mogi CruzesDissemination of a malignant tumour is the result of a cascade of events beginning with detachment of cells from primary tumour followed by extravasation and growth at secondary sites. the differences in metastatic ability could be attributed to properties intrinsic to the various tumour types. Thus the clonal selection of tumour cells from successive metastases apparently results in cells better equipped for survival and formation of colonies in secondary sites, indicating that survival is not a random phenomenon. Many studies of malignant cells have correlated the overexpression of adhesion receptors such as integrins and the production of cysteine proteases and glycosidases with the progression of malignancy. the interaction of cysteine proteases with basement membrane components has been implicated in tumour invasion, activation of hormones and growth factors. On the other hand, the expression of the heparanase gene and its protein has been associated with the metastatic potential of several human and mouse tumour cell lines. This study aimed to investigate the correlations between the metastatic properties of clones with high and low metastatic potential and their ability to adhere to the extracellular matrix and to degrade proteins and sulphated glycosaminoglycans present there. Clonal selection of the B16F10 cell line was performed, and the clones were examined for the expression of an integrin-type laminin receptor. A significantly higher level was detected in a high metastatic clone. Enzymatic assays showed higher activity for alpha-D-N-acetylglucosaminidase, beta-D-N-acetylgalactosaminidase and beta-D-glucuronidase in conditioned medium from low metastatic clones compared with that from high metastatic clones. However, higher endopeptidase activity was observed in conditioned medium from high metastatic clones. in summary, these results showed a positive correlation between high metastatic potential and endopeptidase secretion. Similarly, a positive correlation was observed between low metastatic cells and the secretion of glycosaminoglycan-degrading glycosidases.
- ItemAcesso aberto (Open Access)Hemorrhagic cerebral metastasis as a first manifestation of a hepatocellular carcinoma: case report(Academia Brasileira de Neurologia - ABNEURO, 1998-09-01) Peres, Mario Fernando Prieto [UNIFESP]; Forones, Nora Manoukian [UNIFESP]; Malheiros, Suzana Maria Fleury [UNIFESP]; Ferraz, Henrique Ballalai [UNIFESP]; Stávale, João Norberto [UNIFESP]; Gabbai, Alberto Alain [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)We report herein a rare instance in which a patient presented with a hemorrhagic cerebral metastasis as the initial manifestation of a hepatocellular carcinoma (HCC). A few cases of cerebral metastasis from HCC have been reported in the literature, mainly from eastern countries. This is the first report from South America of a cerebral metastasis from hepatocellular carcinoma.
- ItemSomente MetadadadosImmunohistochemical expression of COX-2 and c-kit in metastatic uveal melanoma(Canadian Ophthal Soc, 2007-02-01) Frota, Ana C. A.; Odashiro, Alexandre N.; Pereira, Patricia R.; Fernandes, Bruno F.; Godeiro, Katyanne Dantas; Souza Filho, Joao Pessoa; Burnier, Miguel N.; Universidade Federal de São Paulo (UNIFESP); McGill UnivCase report: We report a case of choroidal melanoma metastatic to the liver diagnosed by fine-needle aspiration. the biopsy sample was immunostained for COX-2 and c-kit.Comments: Accurate diagnosis and identification of potential therapeutic targets are important for subsequent therapy and can be achieved by radiologically guided fine-needle aspiration biopsy.
- ItemAcesso aberto (Open Access)Líquido cefalorraquiano no diagnóstico de metástase cérebro-meníngea de melanoma maligno derivado de nevo melanocítico gigante congênito: relato de caso(Academia Brasileira de Neurologia - ABNEURO, 1996-09-01) Rolim, José Augusto B. [UNIFESP]; Barsottini, Orlando Graziani Povoas [UNIFESP]; Prado, Gilmar Fernandes do [UNIFESP]; Nakandakare, Fernando [UNIFESP]; Reis, Maria L. A. A. [UNIFESP]; Reis-Filho, J. B. [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)We describe the case of a 28-year-old man with a giant congenital melanocytic nevus (GCMN) with malignant transformation to melanoma and metastasis on the central nervous system (CNS). We also make a summary of the pathological features from both lesions(GCMN and melanoma), the occurrence of malignancy of GCMN, the organs more frequently involved with metastatic melanoma - with emphasis to involvement of CNS -just as the factors that cause malignant transformation of GCMN; the methods to diagnose metastases in CNS - emphasizing the importance of cerebrospinal fluid - and some therapeutical modalities for the metastatic melanoma in CNS.
- ItemAcesso aberto (Open Access)Metástases cervicais bilaterais no carcinoma epidermóide de cabeça e pescoço: tratamento cirúrgico em um ou dois tempos(ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2004-01-01) Amar, Ali [UNIFESP]; Rapoport, Abrão [UNIFESP]; Cervantes, Onivaldo [UNIFESP]; Hospital Heliópolis Departamento de Cirurgia de Cabeça e Pescoço e Otorrinolaringologia; Universidade Federal de São Paulo (UNIFESP)AIM: To assess the results of treatment of bilateral neck metastases in patients with squamous cell carcinoma of upper aerodigestive tract. STUDY DESIGN: Retrospective case-series. MATERIAL AND METHODS: The charts of 855 patients with squamous cell carcinoma of mouth, oropharynx, hypopharynx and larynx who underwent ressection of primary tumor and radical neck dissection were reviewed. Ninety-six patients with histologically proven bilateral neck metastases were selected, 73 underwent bilateral radical neck dissection and 23 unilateral radical neck dissection and developed contralateral recurrence. The free disease survival and neck control rates were evaluated. RESULTS: Between 23 patients who underwent unilateral neck dissection and developed contralateral recurrence, only 18 were salvaged. The neck control after 2 years was achieved in 46% of patients. Between 73 patients who underwent bilateral neck dissection, 12 cases of neck recurrences were diagnosed and only 3 patients were salvaged. The neck control after 2 years was 77%, and the free disease survival was similar between the 2 groups, despite of the difference in neck control rates. CONCLUSION: The bilateral neck dissection in one stage was more effective to control neck disease but no difference of disease-free survival in comparison with two stage procedure was observed. Neck control was reached in most patients, but only 35% of those with bilateral metastases were free of disease after 2 years.