Navegando por Palavras-chave "microbiome"

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    Gut Microbiota Differences in Children From Distinct Socioeconomic Levels Living in the Same Urban Area in Brazil
    (Lippincott Williams & Wilkins, 2016) Mello, Carolina S.; Carmo-Rodrigues, Mirian S.; Araujo Filho, Humberto Bezerra de [UNIFESP]; Melli, Lígia Cristina Fonseca Lahoz [UNIFESP]; Tahan, Soraia [UNIFESP]; Pignatari, Antonio Carlos Campos [UNIFESP]; Morais, Mauro Batista de [UNIFESP]
    Objective:To compare gut microbiota in impoverished children versus children of high socioeconomic status living in the same urban area in Brazil.Methods:A cross-sectional study was conducted to evaluate 100 children living in a slum and 30 children from a private school, ages between 5 and 11 years old, in Sao Paulo State, Brazil. To characterize the groups, data based on socioeconomic status, sanitation, and housing conditions were collected. Anthropometric measurements and neonatal data were obtained from both groups. Gut microbiota were quantified in fecal samples by real-time polymerase chain reaction.Results:The children in the private school group had higher rates of cesarean delivery and premature birth than the children in the slum group. Staphylococcus aureus (90% vs 48.0%) and Clostridium difficile (100% vs 43.0%) were more commonly found in the children from the private school than in the impoverished children (P<0.0001). C perfringens was most frequently identified in the group of children from the slum (92.0% vs 80%
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    Microbiota abnormalities and the therapeutic potential of probiotics in the treatment of mood disorders
    (Walter De Gruyter Gmbh, 2017) Rios, Adiel C. [UNIFESP]; Maurya, Pawan Kumar [UNIFESP]; Pedrini, Mariana [UNIFESP]; Zeni-Graiff, Maiara [UNIFESP]; Asevedo, Elson [UNIFESP]; Mansur, Rodrigo B.; Wieck, Andrea; Grassi-Oliveira, Rodrigo; McIntyre, Roger S.; Hayashi, Mirian A. F. [UNIFESP]; Brietzke, Elisa [UNIFESP]
    Major depressive disorder (MDD) and bipolar disorder (BD) are among the leading causes of burden and disability worldwide. Despite intensified research efforts to improve the treatment options and remission rates in mood disorders, no disease modifying treatment exists for these disorders. Accumulating evidence implicates the involvement of the gut microbiota in processes relevant to etiopathology of central nervous system-based disorders. The objective of this article was to critically evaluate the evidence supporting the link between gastrointestinal microbiota and mood disorders and to discuss the potential benefits of using probiotics in the treatment of MDD and BD. The concept of psychobiotics, which is bacterial-based interventions with mental health benefit, is emerging in the field. On the other hand, while probiotics might potentially represent a significant advance, specific roles of microbiota in the pathophysiology of mood disorders still need further investigation along with intervention studies.