Navegando por Palavras-chave "moléculas de adesão celular"

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    Análise da expressão de moléculas de adesão celular nos linfomas de células t cutâneos e em doenças inflamatórias da pele
    (Universidade Federal de São Paulo (UNIFESP), 2016-11-23) Barata, Mariangela Cristina Crispino [UNIFESP]; Silva, Maria Regina Regis Silva [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)
    To investigate possible differences in cell adhesion molecules expression between mycosis fungoides (MF) and inflammatory skin diseases (drug reactions and allergic contact dermatitis). Patients and Methods: We selected 33 biopsies from patients with mycosis fungoides and 10 biopsies of patients with inflammatory skin diseases from Departamento de Patologia da Universidade Federal de São Paulo (UNIFESP) from January 1997 to December 2013. Expression of ?4?1 integrin, ?E?7 integrin and E-cadherin was assessed by immunohistochemistry in intraepidermal lymphocytes by counting four high power microscopic epidermal fields (400x) and comparing those between the two groups. Results: There was no difference in the expression of integrins ?4?1 and ?E?7 in intraepidermal lymphocytes between cases of MF and inflammatory skin diseases. We observed increased expression of integrin ?E?7 in intraepidermal lymphocytes in advanced stages of MF (T3 and T4) and in cases of MF after treatment. The expression of E-cadherin in epidermal cells in MF outlined Pautrier microabscesses, whereas in inflammatory diseases, spongiosis and intercelular oedema reduced it?s expression in keratinocytes. Conclusion: The increased expression of integrin ?E?7 in advanced stages of MF (T3 and T4) can occur due to increased lymphocyte population or the presence of lymphocytes that also express that integrin, although it may not necessarily be activated. Increased expression of ?E?7 in intraepidermal lymphocytes of posttreatment MF cases may be related to the increase of non-tumoral infiltrating lymphocytes in the epidermis. The expression of E-cadherin in the epidermis in cases of MF outlined Pautrier microabscesses, unlike inflammatory diseases, in which there is swelling, breaking of intercellular bridges and decreased expression of this molecule, showing that tumor lymphocytes may migrate to the epithelium in a less aggressive manner, respecting the structure of keratinocytes.
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    Endométrio na janela de implantação em mulheres com síndrome dos ovários policísticos
    (Associação Médica Brasileira, 2011-12-01) Lopes, Ione Maria Ribeiro Soares [UNIFESP]; Baracat, Maria Cândida Pinheiro; Simões, Manuel de Jesus [UNIFESP]; Simões, Ricardo Santos; Baracat, Edmund Chada [UNIFESP]; Soares Júnior, José Maria [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Piauí; Universidade de São Paulo (USP)
    The human endometrium undergoes to a complex series of prolifertive and secretory changes in each menstrual cycle and displays only a short period of receptivity, known as the window of implantation, necessary for the implantation of the blastocyst in the uterus. The implantation process occurs in a sequential manner, leading to the establishment of pregnancy. Morphofunctional changes during this period may prevent or hinder the implantation. For this reason, the study of the endometrium at this stage is important for the improvement of therapies that may interfere with the mechanisms involved in maternal-embryonic interaction. Several gynecological disorders, including polycystic ovary syndrome (PCOS), are associated with decreased fertility and uterine receptivity. In spite of recent advances in assisted reproduction techniques, allowing the selection of high quality embryos, the implantation rate remains low and has not increased enough in recent decades. This article aims at reviewing the endometrial aspects of the window of implantation in women with polycystic ovary syndrome, focusing mainly on adhesion molecules. For that purpose, we analyzed 105 articles published in journals indexed in PubMed in the last 50 years (up to May 2011). In conclusion, the endometrial receptivity seems to be the major limiting factor for the establishment of pregnancy in a large number of gynecological diseases, including PCOS, and treatment to improve implantation rates is likely to be taken towards this direction.