Navegando por Palavras-chave "myelodysplastic syndrome"

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    Angeíte isolada do sistema nervoso central em paciente com síndrome mielodisplásica: relato de caso
    (Academia Brasileira de Neurologia - ABNEURO, 2004-06-01) Silva, Gisele Sampaio [UNIFESP]; Siqueira Neto, José Ibiapina; Frota, Norberto Anísio Ferreira; Martins, Gabriela Joca; Castro, José Daniel Vieira De; Universidade Federal de São Paulo (UNIFESP); Universidade Federal do Ceara; Universidade de São Paulo (USP); Universidade Federal do Ceara Hospital das Clínicas; Universidade Federal do Ceará
    Isolated central nervous system (CNS) angiitis are vasculitides of undetermined etiology in which only nervous system vessels are affected. In most cases there is no associated systemic disease. We report the case of a 67 years old man with previous hematologic diagnosis of myelodysplastic syndrome who developed an isolated CNS angiitis.
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    Comparison of cytogenetics with FISH in 40 myelodysplastic syndrome patients
    (Elsevier B.V., 2002-11-01) Romeo, M.; Chauffaille, M. D.; Silva, MRR; Bahia, DMM; Kerbauy, J.; Universidade Federal de São Paulo (UNIFESP)
    Karyotyping is important for diagnosis and prognosis of myelodysplastic syndrome (MDS). Using fluorescence in situ hybridization (FISH) either mitotic or interphase cells can be analyzed and a higher number of cells can be screened. This study evaluated the effectiveness of FISH in detecting the most common chromosomal abnormalities [-5/del 5q/-7/+8/del 11q23 and -Y] in 40 patients with MDS. Karyotype detected abnormalities in 35.2% of the patients and FISH in 35%, while some abnormalities remained undetected by each approach but the association of both methods increased the detection rate up to 40%. (C) 2002 Elsevier B.V. All rights reserved.
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    Myelodysplastic syndrome in childhood: report of two cases with deletion of chromosome 4 and the Philadelphia chromosome
    (Elsevier B.V., 2002-06-01) Dalla Torre, Cristiane Arruda [UNIFESP]; Lee, MLD; Yoshimoto, Maysa; Lopes, Luis Fernando; Melo, L. N.; Toledo, Silvia Regina Caminada de [UNIFESP]; Andrade, Joyce Anderson Dufles [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Universidade de São Paulo (USP)
    We report two pediatric patients with unclassified myelodysplastic syndrome (MDS) by the French-American-British (FAB) group. Both cases had clinical and hematological peculiarities, which had not been described yet. the cytogenetic alterations were 4q deletion and the Philadelphia (Ph) chromosome which appeared at different moments of the disease. One patient showed the Ph chromosome at disease transformation and the other at diagnosis. the different breakpoints at 4q and the presence of Ph could be a marker of this form of MDS. the association of clinical and hematological findings suggests the possibility of a new group of pediatric MDS. (C) 2002 Elsevier B.V. All rights reserved.