Navegando por Palavras-chave "myocarditis"

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    Absence of Fas-L aggravates renal injury in acute Trypanosoma cruzi infection
    (Instituto Oswaldo Cruz, Ministério da Saúde, 2009-12-01) Oliveira, Gabriel Melo De; Masuda, Masako Oya; Rocha, Nazaré N; Schor, Nestor [UNIFESP]; Hooper, Cléber S; Araújo-jorge, Tânia C De; Henriques-pons, Andréa; Instituto Oswaldo Cruz-Fiocruz Laboratório de Biologia Celular; Universidade Federal do Rio de Janeiro Instituto de Biofísica Carlos Chagas Filho; Universidade Federal Fluminense Instituto Biomédico Departamento de Fisiologia e Farmacologia; Universidade Federal de São Paulo (UNIFESP); Centro de Criação de Animais de Laboratório Departamento de Controle de Qualidade Animal
    Trypanosoma cruzi infection induces diverse alterations in immunocompetent cells and organs, myocarditis and congestive heart failure. However, the physiological network of disturbances imposed by the infection has not been addressed thoroughly. Regarding myocarditis induced by the infection, we observed in our previous work that Fas-L-/- mice (gld/gld) have very mild inflammatory infiltration when compared to BALB/c mice. However, all mice from both lineages die in the early acute phase. Therefore, in this work we studied the physiological connection relating arterial pressure, renal function/damage and cardiac insufficiency as causes of death. Our results show that a broader set of dysfunctions that could be classified as a cardio/anaemic/renal syndrome is more likely responsible for cardiac failure and death in both lineages. However, gld/gld mice had very early glomerular deposition of IgM and a more intense renal inflammatory response with reduced renal filtration, which is probably responsible for the premature death in the absence of significant myocarditis in gld/gld.
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    Trypanosoma cruzi persistence in the native heart is associated with high-grade myocarditis, but not with Chagas' disease reactivation after heart transplantation
    (Elsevier B.V., 2014-07-01) Benvenuti, Luiz A.; Roggerio, Alessandra; Nishiya, Anna S. [UNIFESP]; Campos, Silvia V.; Fiorelli, Alfredo I.; Levi, Jose E. [UNIFESP]; Universidade de São Paulo (USP); Universidade Federal de São Paulo (UNIFESP)
    BACKGROUND: Chagas' disease reactivation (CDR) after heart transplantation (HTx) is characterized by relapse of the infectious disease, with direct detection of Trypanosoma cruzi parasites in blood, cerebrospinal fluid, or tissues. We investigated whether a detailed pathologic examination of the explanted heart at HTx with evaluation of myocarditis and parasitic persistence or load in the myocardium could be useful to identify patients at high risk of CDR.METHODS: the native hearts of 18 chagasic patients who presented CDR after HTx (CDR+ group) were compared with the native hearts of 16 chagasic patients who never presented CDR in a follow-up of at least 18 months after HTx (CDR- group). the intensity of myocarditis was evaluated semiquantitatively. Parasite persistence/load in the myocardium was investigated through immunohistochemistry for T cruzi antigens and by qualitative and quantitative real-time PCR for T cruzi DNA.RESULTS: the rate of high-grade myocarditis, parasite persistence, and the median of parasitic load and parasitic load/10(6) cells in the CDR+ group were 83.3%, 77.8%, 8.43 x 10(-3), and 9.890, respectively, whereas in the CDR- group the values were 87.5%, 50%, 7.49 x 10(-3), and 17.800. There was no statistical difference between the groups. High-grade myocarditis was present in all 22 samples (100%) with parasite persistence and in 7 of 12 samples (58.3%) with no parasite persistence (p = 0.003).CONCLUSIONS: Although associated with high-grade myocarditis, T cruzi parasite persistence in the myocardium of the native heart is not associated with the occurrence of CDR after HTx. (C) 2014 International Society for Heart and Lung Transplantation. All rights reserved.