Navegando por Palavras-chave "neoplasias de cabeça e pescoço"
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- ItemSomente MetadadadosCuidados paliativos para pacientes com câncer de cabeça e pescoço: impacto no controle da dor e qualidade de vida(Universidade Federal de São Paulo (UNIFESP), 2014-09-24) Eugenio, Cecilia [UNIFESP]; Paiva, Marcos Bandiera Paiva [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Objective: Evaluate whether there was a change in the quality of life and pain management in patients with malignant head and neck tumors referred to the Palliative Care Outpatient Clinic in the Department of Head and Neck Surgery, Federal University of São Paulo (UNIFESP) in a period of three months. Method: 44 patients with one of the following criteria were refered to the clinic: presence of distant metastasis, unresectable tumor, or inoperable patients due to lack of clinical conditions. 42 patients participated in the survey. In all 4 stages of the follow up (first office visit, 30, 60, and 90 days) the following survey was applied: the questionnaires on quality of life of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ) C30 (version 3.0) and EORTC QLQ-C15-PAL, hospital anxiety and depression scale (HADS), and verbal rating scale (VRS) to assess pain. Results: All patients were classified as stage IV and 78.6 % reported pain. There was improvement on pain management from the first return with p = 0.01, which was maintained in other queries. There was improvement in emotional function on the questionnaires on quality of life and reduction of anxiety on HADS after 60 days follow up. Conclusion: The intervention by a palliative care specialist team is able to better manage pain and emotional symptoms of patients with malignant head and neck tumors with advanced disease and no chance of cure.
- ItemAcesso aberto (Open Access)Expressão de glicoesfingolipídeos no carcinoma espinocelular do trato aerodigestivo superior(ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2006-02-01) Marques Filho, Marcílio Ferreira [UNIFESP]; Walder, Fernando [UNIFESP]; Takahashi, Helio Kiyoshi [UNIFESP]; Guimarães, Luciana Lopes [UNIFESP]; Tanaka, Améria Kaori [UNIFESP]; Cervantes, Onivaldo [UNIFESP]; Straus, Anita Hilda [UNIFESP]; Universidade Federal de São Paulo (UNIFESP); Santa Casa de Misericórdia de Itabuna Serviço de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço; Universidade de São Paulo (USP)Glycosphingolipids are integral constituents of cellular membrane, arranged in rafts, and with neoplasic cell anti-social behavior, like uncontrolled cell growth, invasiveness, and metastatic potential. AIM: However, there are few studies about glycosphingolipids (GSL) expression in squamous cell carcinoma (SCC). Since GSL are known to be tumor-associated markers we decided to perform a prospective study on the GSL profiles of SCC. METHOD: Specimens of 33 SCC and normal mucosa were obtained and GSLs were extracted and purified by reverse-phase chromatography on C18 column and alkaline hydrolysis in methanol. GSLs were quantified using densitometry of orcinol-stained HPTLC plates. RESULT: A significant increase of GSLs in SCC (3.57µg/mg) was observed as compared to normal mucosa (1.92µg/mg). In SCC, an increase of 2 to 3 times in the amounts of CDH, CTH, Globoside, and GM3 was observed in comparison to normal mucosa. The identification of GM3 as well as its increased expression in SCC was confirmed unequivocally by HPTLC immunostaining and indirect immunofluorescence using MAb DH2 (anti-GM3). BY analyzing SCC and normal mucosa CMHs by GC/MS, normal mucosa expresses only glucosylceramide whereas SCC cells express both glucosylceramide and galactosylceramide. CONCLUSION: The increase in the amount of GSLs in tumor tissue may represent changes of cell membrane microdomains resulting from the malignant transformation process, which is responsible for greater cell-cell or cell-matrix interaction thereby increasing their potential for infiltration and metastasis.
- ItemAcesso aberto (Open Access)Rabdomiosarcoma de cabeça e pescoço na infância(ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2003-01-01) Neves, Beatrice Mª J. [UNIFESP]; Pontes, Paulo A. de L. [UNIFESP]; Caran, Eliana Maria Monteiro [UNIFESP]; Figueiredo, Claudia [UNIFESP]; Weckx, Luc Louis Maurice [UNIFESP]; Fujita, Reginaldo Raimundo [UNIFESP]; Universidade Federal de São Paulo (UNIFESP)Rhabdomyosarcoma (RMS) is a malignant tumor of immature mesenchymal cells; it can arise from any part of the body. RMS is the most common soft tissue sarcomain the childhood and its most frequent primary site is the head and neck. AIM: The purpose of this study was to review the occurrence of head and neck RMS in childhood and its clinical-histopathologic features. STUDY DESIGN: Clinical retrospective. METHOD: Eighty-two patients with soft tissue sarcoma treated in the Institute of Pediatric Oncology, UNIFESP-EPM, between 1988 and 2002 were included in this study. The medical records of the patients with head and neck soft tissue sarcomas were reviewed. The following parameters were analyzed: incidence of RMS in the childhood and in the head and neck, sex, age, histological classification, primary site, follow-up. RESULTS: In this study, 65% of soft tissue sarcomas were RMS; 33% of RMS were in the head and neck region; 77% of soft tissue sarcoma in this region were RMS. The mean age at diagnosis was 7.62 years, 41% were between 5 and 9 years. In this sample, there were 47% men and 53% women. Embryonic RMS was the predominant histological type (64.6%) and the orbit was the most common primary site (52.8%). One hundred percent, 50% and 33.3% of the parameningeal, nonparameningeal and orbital RMS, respectively, led to death. CONCLUSION: RMS is the most common soft tissue sarcoma in the childhood and the head and neck is the most frequent primary site. Males were more affected by RMS than females. The mean age at diagnosis was 7.62 years and the most frequent age interval was between 5 and 9 years old. The embryonic histological type and the orbit as primary site were predominant. The highest mortality was found for parameningeal RMS and the lowest, for orbital RMS.
- ItemAcesso aberto (Open Access)Reatividade linfonodal e densidade microvascular nas metástases cervicais de carcinoma epidermóide com tumor primário oculto(ABORL-CCF Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial, 2006-06-01) Amar, Ali [UNIFESP]; Giovanini, Allan Fernando; Rosas, Marilene Paladino; Cervantes, Onivaldo [UNIFESP]; Hospital Heliópolis; Centro Universitário Positivo; Universidade Federal de São Paulo (UNIFESP)BACKGROUND: neoangiogenesis and the immune response are important mechanisms in metastasis development. AIM: to evaluate lymph node reactivity and microvessel density in neck metastasis of occult primary squamous cell carcinoma considering their histological and clinical variables. STUDY DESIGN: retrospesctive case-series. METHOD: 19 patients with neck metastasis of occult primary squamous cell carcinoma who underwent neck dissection between 1983 and 2000 were selected. The lymph nodes were reevaluated on the type of reactivity in both the cortical and paracortical areas, and the metastasis were assessed as to grade, desmoplasia, necrosis and microvessel density (CD34). The relationship between histological and clinical variables was evaluated. RESULTS: the median microvessel density was 91 vessels/mm2, varying from 28 to 145. Paracortical hyperplasia was more common in patients below 55 years of age (90% x 44%, p= 0.05), but there was no relationship between reactivity patterns and microvessel density with prognosis. The disease-free survival was 52% in 3 years, being similar in both groups, with higher or lower microvessel densities. CONCLUSION: microvessel density in neck metastasis of occult primary squamous cell carcinoma had a great individual variability. It wasn t possible to establish the relationship between microvessel density and the clinical or histological variables studied.